Browsing Zentren & Graduiertenschulen by Referee "Pieler, Tomas Prof. Dr."
Now showing items 1-20 of 20
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The molecular anatomy of synaptic vesicle recycling at the hair cell ribbon synapse
(2019-11-19)The inner hair cell (IHC) ribbon synapse of the auditory system is a highly specialized synapse, adapted to very fast transmission rates and maintenance of synaptic vesicle release over long periods of time without showing ... -
Investigation of cpeb1 transcript regulation and potential functions of CPEB1 in germline development in X. laevis
(2017-11-17)Germline specification represents the first functional segregation between two cell populations in the embryo. The germ cell lineage is the source of genetic variation and is essential for the continuity of the species. ... -
The Tip60 chromatin remodeling complex is required for maintenance and polarity of Drosophila neural stem cells
(2017-10-10)Stem cells are self-renewing cells which produce differentiating offspring during development and tissue homeostasis. Appropriate regulation of stem cell division is highly important to ensure maintenance of the stem cell ... -
Cellular locomotion and adhesion in the context of different substrate properties
(2017-01-16)This work comprises three different projects dealing with the interplay of cellular locomotion and adhesion to establish a better understanding of the response of cells to their environment. In the first part of this thesis ... -
Mad2l2 as a safeguard for open chromatin in embryonic stem cells
(2016-08-08)Open chromatin is induced locally during the repair of DNA double-strand breaks when a cascade of protein recruitments and modifications is triggered. This "ATM cascade" includes components like the Mrn complex, ATM kinase, ... -
XDazl function in RNA metabolism in Xenopus laevis
(2015-11-25)Germ cell specification in Xenopus laevis depends on the inheritance of maternal determinants from the oocyte in form of mRNAs and proteins. At the onset of zygotic transcription, maternal mRNAs are subjected to miR-mediated ... -
Novel roles of Celf1 and Tia1 during vegetal RNA localization in Xenopus laevis oocytes
(2015-10-29)The localization of certain mRNAs to the vegetal cortex of Xenopus oocytes is of crucial importance for germ cell development and germ layer formation of the future embryo. Vegetal RNA localization is mediated by signal ... -
Pancreatic β-Cell Regeneration in TIF-IA Knockout Mice
(2014-09-30)As the sole source of insulin production in body, pancreatic β-cells play an essential role in glucose homeostasis. Diabetes mellitus is a chronic disease characterized by loss, reduction, and/or malfunction of β-cell mass. ... -
Molecular characterization of Ptf1a activity during Xenopus embryogenesis
(2013-08-01)A balance between inhibitory and excitatory neurons is essential for the establishment of a functional vertebrate nervous system. A key factor in regulating this balance is the bHLH transcription factor Ptf1a, which promotes ... -
The role of innervation during mouse embryonic myogenesis: what molecular genetics tells
(2013-06-19)The interdependency of motor neurons and the skeletal muscle is a classical example for instructive and trophic tissue interactions during development and adult life. It is well established that skeletal muscles undergo ... -
The Role of RNF157 in Central Nervous System Development
(2012-11-05)Apoptosis or programmed cell death is a crucial event during neuronal development to reduce excessive neurons. In addition, neuronal apoptosis is the cause of many neurodegenerative diseases including Alzheimer’s disease ... -
Biochemical and functional differences of chromatin assembled replication-coupled or independent in Xenopus laevis egg extracts
(2012-04-12)Two main chromatin assembly pathways ensure the proper transmission of chromatin organization and chromatin-based information throughout the cell cycle. A replication-dependent (RD) pathway that couples chromatin assembly to ... -
Identification and characterization of molecular mechanisms driving the functional specification of motor neurons The Delta like homolog 1 protein
(2012-03-02)Spinal Motor neurons are playing a decisive role in body posture and locomotion by controlling skeletal muscle contraction via their motor axon termini. During embryonic development motor ... -
The role of microRNAs in the p53 tumor suppressor pathway
(2011-12-16)MicroRNAs (miRNAs) are a class of small, non-coding, double-stranded RNA molecules. In metazoan cells, miRNAs recognize their target mRNAs by imperfectly complementary binding, leading to ... -
Molecular Mechanisms Controlling Guided Germ Cell Migration in Zebrafish
(2009-09-23)During zebrafish embryonic development, primordial germ cells (PGCs) migrate through the developing embryo towards the developing gonad, where they will differentiate into sperm and egg. ... -
Functions of Vti1a and Vti1b in the Development of the Mouse Nervous System: Evidence from Double Knockout Mice
(2009-02-12)In eukaryotic cells molecules need to be transported to their correct intracellular destination without compromising the structural integrity of cellular compartments in order to maintain homoeostasis and to allow appropriate ... -
Regulation of the homeoprotein Hesx1 via Mad2l2 and the anaphase promoting complex
(2008-09-17)Understanding the functional significance of the coordinate expression and interaction of homeobox transcription factors remains a critical question in developmental biology. Hesx1 is a ... -
The Role of alpha- and beta-SNAP in Synaptic Vesicle Exocytosis
(2008-08-04)Neurotransmitter release is mediated by the neuronal SNARE proteins, which are transmembrane proteins whose assembly into ternary complexes is thought to drive membrane fusion of synaptic ... -
Functional Characterisation of Syndecan, a heparan sulpahte proteoglycan, in Slit/Robo signalling
(2008-04-25)Syndecan (Sdc) is a type I transmembrane protein characterized by the presence of linear sugar chains called heparan sulphate glycosaminoglycans (HSGAGs) linked to its extracellular domain. Sdc was shown to be critical for ... -
Untersuchung des TGF-β-induzierten Zelltods in oligodendroglialen Kulturen
(2008-02-12)Apoptosis is controlled by complex networks with various interactions between different signalling pathways regarding to extracellular as well as intracellular signals. Thereby, the transforming growth factor (TGF)-β ...