Browsing Zentren & Graduiertenschulen by Referee "Stülke, Jörg Prof. Dr."
Now showing items 1-20 of 40
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Bioinformatic analyses of complex genomic regions in non-human primate genomes
(2025-12-10)This PhD thesis investigates the application of bioinformatics techniques to annotate and explore complex genomic regions, with an emphasis on the immune-related Natural Killer Group 2 (NKG2) genes in non-human primates. ... -
The roles of GTPases in biogenesis of the large ribosomal subunit
(2025-09-22)Ribosomes are ribonucleoprotein complexes responsible for protein synthesis, and their biogenesis is a complex, highly orchestrated process requiring a significant amount of energy and the coordinated action of all three ... -
Structural and Mechanistic Interrogation of Fatty Acid Biosynthesis Machinery
(2025-05-22)Lipids are important molecules for vital functions in the cell, such as energy storage, membrane structure, cellular signaling, and metabolic control. Lipid metabolism is thus one of the central pathways of all living ... -
Cysteine-rich Receptor-like Kinase 7 functions as a receptor for Wall Teichoic Acid, a MAMP specific for gram-positive bacteria with non-canonical activities in Arabidopsis thaliana
(2024-10-10)Plants are constantly surrounded by a plethora of microorganisms, including fungi, oomycetes, and bacteria. To sense their presence and distinguish between different kinds of microbes, plants utilize a variety of cell-surface ... -
Characterization of stress-induced cytosolic assemblies containing components of the guided-entry of tail-anchored proteins targeting pathway
(2024-09-04)Up to 30% of eukaryotic proteins are integral membrane proteins and need to be targeted to their appropriate membrane locations. The guided entry of tail-anchored proteins (GET) is a key targeting route to the ER membrane ... -
Characterization of abundant unknown proteins that participate in the control of tRNA maturation and fatty acid acquisition in Bacillus subtilis
(2024-07-23)Despite tremendous advances in sequencing and other state-of-the-art technologies, unknown proteins are present in virtually all living organisms. Even though Bacillus subtilis is one of the most extensively annotated model ... -
Amino acid metabolism in Bacillus subtilis
(2024-03-05)Amino acid metabolism is a a central field of research aiming to understand the complex reactions that take place in a cell. Amino acids are the main building blocks for proteins, and they serve as carbon or nitrogen source ... -
Comparative systems biological analysis of the potential of a high-performance expression platform – Bacillus pumilus
(2023-06-29)This project was supported by the German Federal Ministry of Education and Research (BMBF) with the grant ID: Fkz.031B057 under the Industrial Biotechnology Innovation Initiative. The particular program corresponds to the ... -
Validation of novel protein-protein interactions in Bacillus subtilis
(2023-01-12)Protein-protein interactions are the basis for many biological processes in the cell. Understanding these interactions is crucial for the general analysis of how the cell functions and the potential identification of ... -
Structural and functional characterisation of tRNA modifying enzymes
(2021-09-10)Posttranscriptional and posttranslational modifications are key regulatory mechanisms to expand biological properties of proteins and nucleic acids in living cells. A tremendous number of chemical modifications is found ... -
Vitamin B6 metabolism and underground metabolic routes in the Gram-positive bacterium Bacillus subtilis
(2021-07-16)Genome-reduced bacteria give the opportunity to study essential gene functions but also give the starting point for biotechnological production pathways. The MiniBacillus project aims to produce a genome reduced Bacillus ... -
Identification and Characterisation of Lipid Droplet-Localised Proteins
(2021-03-16)Lipid droplets (LD) are unique organelles, whose physiological relevance has been underestimated for a long time. Well-known in seed tissues for storing triacylglycerol (TAG) to fuel post-germinative seedling establishment, ... -
Molecular insights into the roles of RNA helicases during large ribosomal subunit assembly
(2021-02-25)RNA helicases are enzymes present in all domains of life that are important in many aspects of RNA metabolism. They harbor a conserved helicase core that uses the energy of NTP binding and hydrolysis to change affinity to ... -
Clostridioides difficile: Analysis on Single Cell Motility and on Antibiotic Resistance
(2020-12-22)Clostridioides difficile, formerly in the genus Clostridium, is a Gram positive obligatory anaerobic spore forming bacterium. C. difficile is the leading nosocomial gastrointestinal pathogen in the western world. In ... -
Manipulating co-regulators of RUNX2 and SOX9 to enhance the chondrogenic potential of chondrogenic progenitor cells in osteoarthritis
(2020-12-11)Osteoarthritis (OA) is a degenerative disease of the joint leading to the degradation of the articular cartilage. Current therapies cannot halt or reverse the disease, leading to a severe impact on life quality accompanied ... -
A possible functional link between RNA degradation and transcription in Bacillus subtilis
(2020-09-24)Cellular levels of RNA depend on the rate of its synthesis and degradation. While synthesis is performed by RNA polymerase conserved in all domains of life, the enzymes responsible for RNA degradation are more unique ... -
Functional analyses of RNA helicases in human ribosome biogenesis
(2019-10-30)Eukaryotic ribosomes are essential ribonucleoprotein (RNP) complexes consisting of four ribosomal RNAs (18S, 5S, 5.8S, 28S/25S) and approximately 80 ribosomal proteins, which are required for the process of translating the ... -
A protein in search of a function: The c-di-AMP-binding protein DarA of Bacillus subtilis
(2019-07-26)Adaptation to changing environmental conditions is crucial for any organism to thrive in nature. Bacteria like the Gram-positive model organism Bacillus subtilis have evolved so-called second messengers to facilitate ... -
Charakterisierung klinisch-relevanter Bakterien mittels Proteotypisierung
(2019-05-03)In case of a disease outbreak fast and reliable detection of the source of infection is crucial. For this reason, typing of microbial species, also at the below-species level is an important task of clinical microbiological ... -
Identification of essential and virulence genes in Mycoplasma pneumoniae
(2019-04-16)The bacterial group of Firmicutes includes many pathogenic bacteria, as Mycoplasma pneumoniae. The Gram-positive, but cel wall-less bacterium is characterized by a minimal genome with only 694 genes. Elucidating the function ...