Browse by type "doctoralThesis"
Now showing items 1-20 of 1175
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Nucleation of Chemically Active Droplets
(2024-09-10)The interior of a cell is a complicated mixture of many components, and dynamics need to be orchestrated in time and space to ensure the proper functioning of the cell. One key strategy for achieving this tight control is ... -
Investigation of the fusion machinery reconstituted into novel pore-spanning membranes
(2024-09-06)The release of neurotransmitter into the synaptic cleft is achieved by fusion of synaptic vesicles with the presynaptic membrane. This essential process in the neuronal signal transmission is driven by the soluble ... -
Characterization of stress-induced cytosolic assemblies containing components of the guided-entry of tail-anchored proteins targeting pathway
(2024-09-04)Up to 30% of eukaryotic proteins are integral membrane proteins and need to be targeted to their appropriate membrane locations. The guided entry of tail-anchored proteins (GET) is a key targeting route to the ER membrane ... -
Pairing transcranial direct current stimulation and mindfulness meditation in the treatment of fibromyalgia
(2024-08-22)The lack of effective treatments for managing pain and associated symptoms in fibromyalgia (FM) poses both a clinical challenge and an economic burden on the health sector. Typical FM therapies include an array of ... -
Mechanistic Characterization of CDK9 Inhibition in T-Cell Lymphoma
(2024-08-20)Mature T-cell lymphomas (mTCL) comprise a rare group of lymphoid malignancies with very diverse genetical, clinical, and pathological characteristics that are in many cases associated with poor prognosis. Current therapy ... -
Resolving chromatin interaction and transcriptional networks in mammalian nuclei
(2024-08-15)The nucleus is a highly organized machine. Chromatin organization, transcription, and RNA processing are working harmoniously in a specialized but communicative way to pass the information from DNA to mature RNA. In the ... -
Investigations of signal-enhanced magnetic resonance contrast agents
(2024-08-15)Nuclear magnetic resonance spectroscopy (NMR spectroscopy) and its related technique, magnetic resonance imaging (MRI), enable scientists and doctors to make statements about the atomic structure of a sample and to ... -
Computational methods for prokaryotic (meta)genomic annotation and function prediction using horizontal information transfer
(2024-08-05)In recent decades, there has been a surge in genomic sequences resulting from large-scale genomic and metagenomic sequencing projects, driven by the significant drop in sequencing costs. More powerful methods to annotate ... -
Characterization of abundant unknown proteins that participate in the control of tRNA maturation and fatty acid acquisition in Bacillus subtilis
(2024-07-23)Despite tremendous advances in sequencing and other state-of-the-art technologies, unknown proteins are present in virtually all living organisms. Even though Bacillus subtilis is one of the most extensively annotated model ... -
Identification of host factors for the replication of the Kaposi’s sarcoma- associated herpesvirus (KSHV) and the related rhesus monkey rhadinovirus (RRV)
(2024-07-23)Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus. It is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. KSHV is known to interact with several different ... -
Function and homeostasis of non-proteinogenic amino acids in Bacillus subtilis
(2024-07-23)The gram-positive soil bacterium Bacillus subtilis lives in a constantly changing environment, requiring rapid adaptation to survive and thrive. This forces the bacteria to adapt to nutrient availability or stressful ... -
UV and chemical crosslinking mass spectrometry for the analysis of protein-nucleic acid interactions
(2024-07-12)Protein-nucleic acid interactions are a key part of essential cellular processes and their disturbance often results in the development of diseases. Crosslinking mass spectrometry (XL-MS)-based approaches have become ... -
Investigating the Importance of DNA Sequence for Nucleosome Positioning with Means of Machine Learning
(2024-07-09)Nucleosomes are protein complexes condensing DNA molecules to tight chromatin bun- dles to fit into the nucleus. The positioning of nucleosomes on the DNA mediates access to positions for DNA-binding proteins or enzymes ... -
A crosstalk between NF-κB and STAT1 signal transduction pathways in ischemic and proliferative diseases
(2024-07-08)The cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) executes anti-microbial and pro-apoptotic functions, while loss-offunction mutations in the STAT1 gene are associated with ... -
Behavioral analyses in translational neuropsychiatric research
(2024-07-05)Cognitive impairment frequently co-occurs in a variety of neuropsychological disorders, making it an increasing burden to the affected individuals, their relatives, and society in general. Diagnostic procedures usually ... -
Functional Annotation of Gretchen Hagen 3 Enzymes
(2024-07-05)Plants employ a multitude of phytohormones to regulate all aspects of their physiology ranging from their development to specific, environment-dependent responses to threats and other cues. The integration of all these ... -
Proactive planning of action sequences
(2024-07-05)Everyday tasks often require a sequence of actions. Knowing which actions will follow, allows us to proactively prepare for subsequent actions before the first action has been executed. This thesis investigated the neural ... -
Developing tools for translational In-vivo cochlear optical stimulation
(2024-07-02)Utilizing optogenetic stimulation to target type I spiral ganglion neurons (SGNs) could promise an alternative to the currently employed electrical stimulation by current cochlear implants (CIs). Given light's spatial ... -
Investigations of Synaptic Alterations in Models of Parkinson’s Disease
(2024-07-02)Alpha-synuclein (aSyn) is a presynaptic protein implicated in physiological synaptic roles, though its precise function is largely unknown. In Parkinson's disease (PD), the initial pathological events often involve synaptic ... -
Investigation of a putative circuit in the mouse retina
(2024-06-27)Retinal ganglion cells of the vertebrate retina are tuned to detect specific features of the visual scene and effectively decompose it into different channels that are transmitted to and used by the brain to create the ...