Browse by type "doctoralThesis"
Now showing items 1-20 of 1229
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Molecular Physiology of Synaptic Sound Encoding
(2025-04-10)Cochlear inner hair cells (IHCs) of the auditory system form specialised chemical synapses called ribbon synapses with type I spiral ganglion neurons (SGNs). These synapses encode sound information into neural signals for ... -
Optimal Control Methods for Biomolecular NMR Spectroscopy
(2025-04-04)Bio-molecular NMR studies are usually limited by the sensitivity and resolution, especially for concentration limited samples such as IDPs, in-cell samples and metabolomics studies, etc. Hence it is essential to use a ... -
Biochemical Characterization of Otoferlin, the Ca2+ sensor for exocytosis at inner hair cell synapses
(2025-03-27)Transmission of sound from the ear to the brain requires high temporal and spatial fidelity. Inner hair cells (IHC) of the inner ear are the primary sensory organ of hearing, forming the first synapse of the auditory ... -
Cortical PV and VIP neurons are necessary for texture discrimination performance of freely behaving mice
(2025-03-27)Rodents gather information about their surroundings through their whiskers, enabling them to differentiate textures, recognize objects, and navigate. Each whisker is represented in the barrel cortex (S1BF) by a single ... -
Structural and biochemical studies on co-transcriptional endonuclease reactions
(2025-03-25)Influenza, an acute respiratory disease, causes 290,000 to 650,000 human deaths annually (Iuliano et al., 2018; WHO, 2023). During an influenza infection, the virus ensures proper handling of viral mRNA, including nuclear ... -
Viscoelastic properties of epithelial cells: 3D structures and composite elements
(2025-03-14)Epithelial cells form complex, polarized layers in the body to cover organs and cavities. While the mechanical properties of single cells and 2D monolayers have been extensively studied, recent research suggests that 3D ... -
Molecular dynamics simulations of ion permeation and gating in potassium channels
(2025-03-13)Potassium (K+) channels are transmembrane ion channels that conduct K+ ions with exceptional selectivity and permeation rates. K+ channels participate in a plethora of important cellular processes, including termination ... -
Dynamics and composition of signaling droplets reveal an impact of cellular transport during B cell activation
(2025-03-13)B cell activation during immune responses relies on the signaling network downstream the B cell antigen receptor (BCR). BCRs engaged by an antigen recruit a plethora of signal transducers forming BCR signalosomes, which ... -
Bone Morphogenetic Protein signaling in the planarian flatworm Schmidtea mediterranea – evolutionary, cellular, and spatial patterns
(2025-03-13)In early development, morphogen gradients orchestrate the establishment of body axes. Perturbations of such a fundamental process are often damaging to embryonal development, making it difficult to study the role of body ... -
Fluorescence-lifetime image scanning microscopy
(2025-03-13)Improving optical resolution and image quality has always been an important goal in the field of microscopy. One technique that histori- cally played a major role in the optimization of image quality has been confocal ... -
Motor adaptation under visual feedback uncertainty
(2025-03-07)Our motor system continuously receives sensory feedback from our limbs to control movement. This feedback is crucial for compensating for perturbations that disrupt proper control, a process known as motor adaptation. ... -
Uncovering the mode of action of small molecule inhibitors against the RNA polymerase of SARS-CoV-2
(2025-03-07)Severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) is the causative agent of coronavirus disease 2019 (COVID-19). The pandemic has claimed more than 7 million lives since its outbreak at the beginning of 2020, ... -
The Neuropharmacological Basis of Attention in Rhesus Macaques
(2025-03-07)This thesis aimed at unraveling the neuropharmacological basis of attention in rhesus macaques, focusing on the involvement of different neurotransmitter systems. Attention, as a selective filtering process, is crucial ... -
Multisensory integration under visual target uncertainty during planning of reaching movements
(2025-02-25)Movements are fundamental to human interaction and everyday function, relying on the integration of multiple sensory inputs for precise planning and execution. However, sensory uncertainty, particularly in the visual domain, ... -
Thalamic Contributions to Internal Models for Motor Control
(2025-02-24)The ability of the motor system to control movements ensures successful goal-directed actions through our interaction with the environment. Motor adaptation is a process through which we maintain and adapt the existing ... -
Disinhibitory circuit motifs in the mouse primary somatosensory (barrel) cortex
(2025-02-24)The barrel cortex is the part of the rodent neocortex where the tactile information from the whiskers is processed. In the barrel cortex, each whisker is represented by a single cortical column isomorphic to the whiskers ... -
Perceptual Misbinding of Color and Motion - Visual Feature Integration in Humans and Macaques
(2025-02-24)To interact with our environment, sensory signals must be translated into perceptions that guide our behavior. However, our noisy, crowded, and dynamic environment provides too much information to process. As a result, our ... -
Auditory nerve function in mouse models of ATP11A and CABP1-CABP2 related hearing loss
(2025-02-10)Hearing loss can be caused by varied factors affecting diverse structures of the auditory system such as the middle ear, the stria vascularis, the outer hair cells (OHC), inner hair cells (IHC), the spiral ganglion neurons ... -
Fluorescence Correlates of Single Vesicles to Analyze the Behavior of Membrane-manipulating Proteins
(2025-01-24)Soluble NSF-attachment protein receptors (SNAREs) are integral to eukaryotic membrane fusion, providing the necessary energy to surmount the repulsive forces between two opposing membranes. This is achieved through the ... -
The role of RNA in synaptic physiology and neurodegeneration in synucleinopathies
(2025-01-23)Synucleinopathies are neurodegenerative disorders characterised by the pathological accumulation and aggregation of the protein alpha-synuclein (aSyn). Parkinson’s disease (PD), Dementia with Lewy bodies (DLB), multiple ...