• From a First Seizure to Chronic Epilepsy – A Structural and Functional Study 

  Segovia Oropeza, Marysol (2025-01-23)

  Diagnosing epilepsy after a first unprovoked seizure is challenging, especially in patients without detectable lesions on standard magnetic resonance imaging (MRI) and without interictal epileptiform discharges (IEDs) ...

• The role of RNA in synaptic physiology and neurodegeneration in synucleinopathies 

  Chopra, Avika (2025-01-23)

  Synucleinopathies are neurodegenerative disorders characterised by the pathological accumulation and aggregation of the protein alpha-synuclein (aSyn). Parkinson’s disease (PD), Dementia with Lewy bodies (DLB), multiple ...

• The role of Hsp42 in proteostasis-metabolism interplay and cellular longevity 

  Lippi, Alice (2025-01-23)

  Aging is a natural phenomenon characterized by a progressive decline despite complex pathways of maintenance and repair. Over time, cells experience profound changes in cell morphology as well as alterations in gene ...

• What an Insect Brain Can Tell Us: The Impact of Intrinsic and Extrinsic Factors on Long-Term Memory in Drosophila melanogaster Larvae 

  Franz, Hanna Rebekka (2025-01-10)

  Learned associations can be consolidated into long-lasting memory traces, influenced by the relevance and abundance of information, as well as internal states of the animal. In adult Drosophila two distinct forms of ...

• Strategies for decreasing aneuploidy in mammalian oocytes 

  Yusuf, Halima (2025-01-10)

  Female mammals experience a decline in fertility with age that has been attributed to the progressive depletion of the finite ovarian reserve and an increase in the incidence of aneuploid oocytes. Aneuploid oocytes can ...

• Structure, Mechanism and Regulation of human UMP Synthase 

  Kirck, Laura Liliana (2025-01-10)

  Enzymes are of critical importance for a large range of biochemical reactions, catalyzing the conversion of a substrate to a product by lowering the energy of the transition state. The resulting rate acceleration in ...

• Molecular mechanisms and cellular functions of RNA methyltransferases targeting non-coding RNAs 

  Kleiber, Nicole (2024-12-23)

  Cellular RNAs contain diverse modified nucleotides that regulate their structure, stability, biogenesis and molecular functions. In abundant non-coding RNAs such as ribosomal (r)RNAs, transfer (t)RNAs and small nuclear ...

• Rate-limiting steps of autophagy initiation 

  Patel, Anoshi (2024-12-23)

  Autophagy research has progressed tremendously since the identification of ‘ATG’ genes and proteins responsible for maintaining the process. A dissection of general functions of all proteins involved was possible. However, ...

• Investigation of the dual role of mL62 during the mitoribosome assembly and rescue 

  Challa, Venkatapathi (2024-12-19)

  Mitochondria are eukaryotic organelles, which have their own DNA (mtDNA) that encode for 13 proteins that are essential for the oxidative phosphorylation. The mitochondrial ribosome (mitoribosome) is responsible for the ...

• Characterization of VAPA at the inner nuclear membrane: localization, membrane insertion and nuclear interactome 

  Rodríguez González, Inés (2024-12-19)

  Tail-anchored (TA) proteins are type IV single-pass membrane proteins characterized by a long hydrophobic transmembrane domain (TMD) positioned very close to a notably short C-terminus facing the lumen. Due to their topology, ...

• Mechanisms of Ribosomal Translation studied by Molecular Dynamics Simulations 

  Gabrielli, Sara (2024-12-17)

  During translation, the ribosome moves along the mRNA and decodes the genetic information to synthesize proteins. This process proceeds in a step-wise iterative manner during which the ribosome undergoes conformational ...

• Transport mechanisms of the putative vesicular nucleotide transporter VNUT 

  Struck, Jennifer (2024-12-13)

  The vesicular nucleotide transporter VNUT (SLC17A9) is thought to refill recycled synaptic vesicles and other secretory vesicles with adenosine triphosphate (ATP) for chemical signal transmission. ATP translocation by VNUT ...

• The dynamics of singularities in passive, driven, and active matter 

  Romano, Jacopo (2024-12-13)

  Out-of-equilibrium statistical physics studies the time evolution of large collections of particles in terms of a reduced number of meso- and macroscopic observables. Their nature emerge from of the underlying microscopic ...

• Mechanisms of chromosome segregation in mammalian oocytes 

  Saha, Debojit (2024-12-10)

  Errors in chromosome segregation in human females often result in eggs with the wrong number of chromosomes, a condition known as aneuploidy. The rate of aneuploidy increases dramatically in women with age, particularly ...

• Advancements in Nanobody Applications: From Live Synaptic Imaging to Multiplexed Fluorescence Microscopy and Nanoscale Topography Mapping 

  Mougios, Nikolaos (2024-12-09)

  Fluorescence microscopy facilitates biological research by enabling straightforward visualization of fluorescently labeled proteins in live and fixed samples. Despite significant progress in microscopy techniques, including ...

• Host cell entry and antibody evasion of SARS-CoV-2 and animal sarbecoviruses 

  Zhang, Lu (2024-11-29)

  The emergence of SARS-CoV-2 has heightened global awareness of coronaviruses, following previous outbreaks of SARS-CoV and MERS-CoV, which originated in animals and were transmitted to humans, causing severe disease. ...

• PUCK: Primer Utilised CRISPR/Cas Knock-Ins for High Throughput Super-Resolution Microscopy 

  Dohrke, Jan-Niklas (2024-11-29)

  The insertion of tags into proteins via gene editing is a powerful tool for microscopy, enabling the comparative analysis of different proteins. The advent of CRISPR/Cas systems has greatly simplified gene editing and ...

• Functions and Origins of Nonlinear Processing in the Retina 

  Nitsche, Steffen (2024-11-29)

  Millions of people worldwide suffer from terminal blindness, but state-of-the-art vision restoration devices can only produce a sensation fundamentally different from natural seeing. We lack the sufficient understanding ...

• Formation, regulation and dynamics of phase separated postsynaptic density condensates with Tau and Fyn 

  Shen, Zheng (2024-11-22)

  Alzheimer’s disease is characterized by memory loss and cognitive impairments. The cognitive deficits and synaptic dysfunction are associated with the excitotoxicity mediated by NMDA (N-methyl-D-aspartate) receptors on the ...

• Dynamics and regulation of the mitochondrial translation machinery 

  Schöndorf, Thomas (2024-11-15)

  Throughout this project, we have successfully established and implemented a ribosome profiling protocol tailored for examination of translating mitochondrial ribosomes, thereby affording a deeper understanding of mitochondrial ...

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