• Analysis of unconventional plant defence suppression by the signal peptide peptidase Spp1 in the Ustilago maydis - maize interaction 

  Kühne, Nora Marie (2026-01-15)

  In the smut fungus Ustilago maydis, the signal peptide peptidase (SPP) Spp1 is essential for plant defence suppression and establishment of a compatible biotrophic interaction with its host plant maize. SPPs are endoplasmic ...

• Dissection of the initial steps and dynamics in synaptic vesicle biogenesis using custom-refined nano-affinity tools 

  Rehm, Ronja (2026-01-14)

  Synaptic vesicles (SVs) are among the most complex cellular structures studied in neuroscience. They consist of several different components that must be precisely assembled to perform numerous important functions, not ...

• The effect of parasitic plants on host plant immunity against microbial pathogens 

  Bhukya, Durga Prasad Naik (2026-01-13)

  Plants in natural environments are frequently exposed to multiple biotic and abiotic stresses, and their combined effects often trigger complex and non-additive physiological and molecular responses (Suzuki et al., 2014). ...

• Intraspecific signalling regulates protohaustorium formation in the parasitic plant Phtheirospermum japonicum 

  Kenea, Hawi Deressa (2026-01-12)

  Mass occurrences of parasitic plants from the Orobanchaceae family pose significant challenges in agricultural settings. The impact of parasitic weeds such as Striga and Rhamphicarpa increases markedly with parasite density, ...

• Mechanisms of mitochondrial RNA maturation 

  Finke, Anna Franziska (2026-01-06)

  Cellular energy production is essential for sustaining life and is largely enabled by the presence of a functional respiratory chain in mitochondria. The proper assembly and function of this system are crucial for cellular ...

• Dynamic Gain Analysis of Neuronal Response in Experimental and Computational Models under Electrical and Optogenetic Stimulation 

  Wesch, Neil Lewis (2025-12-17)

  Local cortical circuits in the mammalian neocortex encode and process information through the coordinated spiking activity of large neuronal populations. Despite the high variability and low firing rate of individual spike ...

• Bioinformatic analyses of complex genomic regions in non-human primate genomes 

  Ahumada Arranz, Laura (2025-12-10)

  This PhD thesis investigates the application of bioinformatics techniques to annotate and explore complex genomic regions, with an emphasis on the immune-related Natural Killer Group 2 (NKG2) genes in non-human primates. ...

• Transcriptomic Mechanisms in Post-mitotic and Excitable Cells in Inter-Organ Communication 

  Gisa, Verena (2025-12-04)

  The human body functions as an integrated network where organs communicate through complex molecular signals rather than as isolated systems. This inter-organ communication occurs through various mediators including proteins, ...

• The Role of Synaptic Signalling Activity in Brain Development 

  Moschref, Frederieke Sophie (2025-12-02)

  Dynamic changes in synapse structure are essential for memory formation and require newly synthesized synaptic proteins to either replace aged or damaged proteins, or to alter synaptic signalling efficacy (Costa-Mattioli ...

• Investigations of New Magnetic Resonance Contrast Agents 

  Fries, Lisa Maria (2025-11-26)

  Magnetic resonance spectroscopy (MRS) and imaging (MRI) are powerful noninvasive techniques for probing biochemical composition and anatomy. However, the inherently low sensitivity of these magnetic resonance techniques ...

• Fidelity of protein synthesis in vivo 

  Freyer, Nicola Sonja (2025-11-12)

  Protein synthesis fidelity is essential for maintaining proteome integrity and cellular fitness. Errors, such as amino acid misincorporations caused by incorrect decoding, result in aberrant proteins that promote proteotoxic ...

• The role of Sec61β in Ebola and Marburg virus glycoprotein processing and the potential of the Sec61 channel as antiviral target 

  Decker, Katharina Emma (2025-11-10)

  Ebola virus (EBOV) and Marburg virus (MARV), members of the family of Filoviridae, are highly pathogenic for humans and non-human primates (NHPs) and lead to reoccurring outbreaks mainly in the region of West, East and ...

• In situ Structural Studies of α-Synuclein Fibrils 

  Sicking, Kevin (2025-11-06)

  Protein aggregation into amyloid fibrils is a hallmark of many human diseases, yet the structural principles that govern fibril organization and their physiological consequences remain incompletely understood. This thesis ...

• The role of STAT1 signal transduction in the pathogenesis of Alzheimer’s disease 

  Büschgens, Dr. Luca (2025-11-06)

  Chronic neuroinflammation is considered a key hallmark of Alzheimer’s disease (AD) and may represent a central mechanism in its pathogenesis. Microglia, the resident immune cells of the central nervous system (CNS), are ...

• Investigating Mitochondrial Presequence Import 

  Jain, Naintara (2025-10-29)

  Mitochondrial biogenesis and function depend on the accurate import of nuclear-encoded proteins via specialized translocase complexes. Disruptions in these import pathways are implicated in numerous mitochondrial disorders, ...

• Characterizing a Novel Powerful Channelrhodopsin Variant for Preclinical Studies on Optogenetic Cochlear Implants 

  El May, Fadhel (2025-10-29)

  Contemporary electrical cochlear implants (eCI) directly stimulate spiral ganglion neurons (SGNs) using electric current to partially restore auditory function in patients diagnosed with profound sensorineural hearing loss ...

• Advanced Correlation Spectroscopy and Nanofluidics in Single-Molecule Biophysics 

  Sakhapov, Damir (2025-10-28)

  Fluorescence Correlation Spectroscopy (FCS) is a powerful and widelyused technique in biophysics for studying biomolecules and their interactionsat the single-molecule level. However, traditional FCS hasnotable limitations. ...

• Immortalized Primate Granulosa Cell Lines and Pluripotent Stem Cell-Derived Early Germ Cells: Towards Ovarian Follicles In Vitro 

  Ghazanfari Sarabi, Shabnam (2025-10-24)

  Access to primate ovarian tissue and mature oocytes is extremely limited, yet these resources are crucial for advancing both infertility treatment and fundamental research in reproductive biology. Conventional sources are ...

• Role of PSD-95 in mouse binocular vision: A combined behavioural and 2-photon Ca2+ imaging study 

  Bhattacharya, Subhodeep (2025-10-22)

  Visual cortical circuits undergo a temporally restricted period of heightened plasticity early in neurodevelopment, termed the critical period (CP; Hubel and Wiesel, 1962, 1963). Crucial visual abilities, such as binocularity, ...

• Chromatin remodeling BAF complex dependent mechanisms in development of cortical interneurons 

  Mao, Xiaoyi (2025-10-21)

  GABAergic inhibitory neurons contribute to the excitatory and inhibitory balance in the brain. Dysfunction in GABAergic neuron development is implicated in various neurodevelopmental disorders. In recent years, the ...

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