• Investigation of the fusion machinery reconstituted into novel pore-spanning membranes 

  Sari, Merve (2024-09-06)

  The release of neurotransmitter into the synaptic cleft is achieved by fusion of synaptic vesicles with the presynaptic membrane. This essential process in the neuronal signal transmission is driven by the soluble ...

• Characterization of stress-induced cytosolic assemblies containing components of the guided-entry of tail-anchored proteins targeting pathway 

  Jennrich, Jonas (2024-09-04)

  Up to 30% of eukaryotic proteins are integral membrane proteins and need to be targeted to their appropriate membrane locations. The guided entry of tail-anchored proteins (GET) is a key targeting route to the ER membrane ...

• Pairing transcranial direct current stimulation and mindfulness meditation in the treatment of fibromyalgia 

  Ramasawmy, Perianen (2024-08-22)

  The lack of effective treatments for managing pain and associated symptoms in fibromyalgia (FM) poses both a clinical challenge and an economic burden on the health sector. Typical FM therapies include an array of ...

• Mechanistic Characterization of CDK9 Inhibition in T-Cell Lymphoma 

  Ksionsko, Nora Anna Maria (2024-08-20)

  Mature T-cell lymphomas (mTCL) comprise a rare group of lymphoid malignancies with very diverse genetical, clinical, and pathological characteristics that are in many cases associated with poor prognosis. Current therapy ...

• Resolving chromatin interaction and transcriptional networks in mammalian nuclei 

  Zhu, Yajie (2024-08-15)

  The nucleus is a highly organized machine. Chromatin organization, transcription, and RNA processing are working harmoniously in a specialized but communicative way to pass the information from DNA to mature RNA. In the ...

• Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry 

  Ainatzi, Sofia (2024-08-15)

  Communication between neurons takes place at synapses, where the transmission of information from the presynaptic neuron to the postsynaptic cell involves the Ca2+-regulated fusion of synaptic vesicles (SVs) with the ...

• Investigations of signal-enhanced magnetic resonance contrast agents 

  Sternkopf, Sonja Katharina (2024-08-15)

  Nuclear magnetic resonance spectroscopy (NMR spectroscopy) and its related technique, magnetic resonance imaging (MRI), enable scientists and doctors to make statements about the atomic structure of a sample and to ...

• Computational methods for prokaryotic (meta)genomic annotation and function prediction using horizontal information transfer 

  Zhang, Ruoshi (2024-08-05)

  In recent decades, there has been a surge in genomic sequences resulting from large-scale genomic and metagenomic sequencing projects, driven by the significant drop in sequencing costs. More powerful methods to annotate ...

• Learning-dependent plasticity of the Drosophila mushroom body: An optophysiological approach 

  Deimel, Stephan Hubertus (2024-07-29)

  Functional changes in the neuronal network of our brain enable experience-dependent adaptations to the environment through our behavior, referred to as learning and memory. One fundamental topic has occupied the neurosciences ...

• Function and homeostasis of non-proteinogenic amino acids in Bacillus subtilis 

  Warneke, Robert (2024-07-23)

  The gram-positive soil bacterium Bacillus subtilis lives in a constantly changing environment, requiring rapid adaptation to survive and thrive. This forces the bacteria to adapt to nutrient availability or stressful ...

• Characterization of abundant unknown proteins that participate in the control of tRNA maturation and fatty acid acquisition in Bacillus subtilis 

  Wicke, Dennis (2024-07-23)

  Despite tremendous advances in sequencing and other state-of-the-art technologies, unknown proteins are present in virtually all living organisms. Even though Bacillus subtilis is one of the most extensively annotated model ...

• Improving Cognition in Older Adults Through Transcranial Electrical Stimulation And Cognitive Training 

  Diedrich, Lukas (2024-07-23)

  The progressive aging of the global population continues unabated. Consequently, there is a substantial increase in the prevalence of neurocognitive disorders, primarily observed in the elderly. Current pharmacological ...

• Identification of host factors for the replication of the Kaposi’s sarcoma- associated herpesvirus (KSHV) and the related rhesus monkey rhadinovirus (RRV) 

  Scribano, Stefano (2024-07-23)

  Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus. It is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. KSHV is known to interact with several different ...

• UV and chemical crosslinking mass spectrometry for the analysis of protein-nucleic acid interactions 

  Welp, Luisa (2024-07-12)

  Protein-nucleic acid interactions are a key part of essential cellular processes and their disturbance often results in the development of diseases. Crosslinking mass spectrometry (XL-MS)-based approaches have become ...

• Investigating the Importance of DNA Sequence for Nucleosome Positioning with Means of Machine Learning 

  Sahrhage, Malte (2024-07-09)

  Nucleosomes are protein complexes condensing DNA molecules to tight chromatin bun- dles to fit into the nucleus. The positioning of nucleosomes on the DNA mediates access to positions for DNA-binding proteins or enzymes ...

• A crosstalk between NF-κB and STAT1 signal transduction pathways in ischemic and proliferative diseases 

  Sheikh, Sana Mumtaz (2024-07-08)

  The cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) executes anti-microbial and pro-apoptotic functions, while loss-offunction mutations in the STAT1 gene are associated with ...

• Behavioral analyses in translational neuropsychiatric research 

  Hindermann, Frank Martin (2024-07-05)

  Cognitive impairment frequently co-occurs in a variety of neuropsychological disorders, making it an increasing burden to the affected individuals, their relatives, and society in general. Diagnostic procedures usually ...

• Functional Annotation of Gretchen Hagen 3 Enzymes 

  Ni, Benedikt (2024-07-05)

  Plants employ a multitude of phytohormones to regulate all aspects of their physiology ranging from their development to specific, environment-dependent responses to threats and other cues. The integration of all these ...

• Proactive planning of action sequences 

  Hansmeyer, Laura (2024-07-05)

  Everyday tasks often require a sequence of actions. Knowing which actions will follow, allows us to proactively prepare for subsequent actions before the first action has been executed. This thesis investigated the neural ...

• Developing tools for translational In-vivo cochlear optical stimulation 

  Thirumalai, Anupriya (2024-07-02)

  Utilizing optogenetic stimulation to target type I spiral ganglion neurons (SGNs) could promise an alternative to the currently employed electrical stimulation by current cochlear implants (CIs). Given light's spatial ...

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