• A light-inducible Na+ pump to study the role of intracellular Na+ accumulation in heart failure 

  Kiehn, Svenja Mareike (2024-10-10)

  Elevated Nai levels have been identified as a significant factor in the development of heart failure, observed across multiple species. This is caused by downregulated NKA, increased NHE activity and elevated late Na+ ...

• Phospholamban – Characterization of the Potential Interaction Partner SLMAP 

  Zaremba, Nina (2024-10-10)

  The identification of novel PLN interaction partners is of high importance to understand how it is regulated on a molecular level and to develop new therapeutic strategies for cardiomyopathy. SLMAP, a novel putative PLN ...

• Cysteine-rich Receptor-like Kinase 7 functions as a receptor for Wall Teichoic Acid, a MAMP specific for gram-positive bacteria with non-canonical activities in Arabidopsis thaliana 

  Pierdzig, Leon (2024-10-10)

  Plants are constantly surrounded by a plethora of microorganisms, including fungi, oomycetes, and bacteria. To sense their presence and distinguish between different kinds of microbes, plants utilize a variety of cell-surface ...

• The Verticillium effector TRADE induces host plant cell identity switches by co-opting the osmotic stress and wound response pathways 

  Lübbers, Jan-Niclas (2024-10-08)

  Climate change not only increases the abiotic stress of our crops but also favors the spread of their pathogens. Thus, understanding the molecular mechanisms of plant-pathogen interactions is more important than ever. ...

• Analysis of the regulation of ICS1-independent SAR gene expression by N-hydroxy-pipecolic acid 

  Goyal, Isha (2024-10-08)

  Systemic acquired resistance (SAR) is a plant immune response that ripostes a local pathogen attack. A mobile signal, induced in infected plant cells, travels from these infected tissues to systemic leaves. This prepares ...

• Bayesian Inference for Top-Down Protein Markov Models and the Ubiquity of Michaelis-Menten Kinetics 

  Schäffner, Malte Norman (2024-10-04)

  The current understanding of protein function predominantly relies on the concept of describing proteins as comprising discrete conformational and chemical states including transitions between these states. The theory of ...

• Interactions between cytoskeletal filaments in cells 

  Blob, Anna Friederike (2024-10-04)

  Essential functions of eukaryotic cells such as cell division, force generation and the ability to mechanically adapt to the outer environment depend on the cytoskeleton, which is an intricate network containing three ...

• Development of Analysis- and Simulation-Routines for ENDOR Spectroscopy 

  Kehl, Annemarie (2024-10-04)

  Electron paramagnetic resonance (EPR) spectroscopy allows obtaining structural information on for example biomolecules by investigating the magnetic environment of paramagnetic centers on the atomic to nanoscale. This ...

• Development of an in-silico framework for the engineering and evaluation of future optogenetic cochlear implants 

  Khurana, Lakshay (2024-09-27)

  Hearing loss is a prevalent global challenge with profound cognitive, psychological, social, and economic implications. Traditional cochlear implants (CIs)—neuroprosthetic devices to partially restore hearing—stimulate the ...

• Identification of novel rate-limiting components in Arabidopsis cell entry control against non-adapted fungal pathogens 

  Mittendorf, Josephine (2024-09-27)

  Cell entry into host cells represents a crucial step during pathogenesis of fungal phytopathogens. However, plants have evolved an effective cell entry control mechanism to block a majority of intruders at the front line. ...

• Role of internal mRNA modifications in modulating translation elongation 

  Jain, Sakshi (2024-09-26)

  Translation is a highly regulated process that defines the composition of the cellular proteome. Numerous mechanisms are known to fine-tune the translational output at different cellular conditions. Recently, a new regulatory ...

• Development of Methods for Cardiac Tissue Characterization Using Magnetic Resonance Imaging in Animal Models 

  Ramedani, Majid (2024-09-26)

  Cardiovascular diseases (CVDs) are the primary cause of death and disability globally. The progression of CVDs is often associated with functional and structural alterations, including reduced myocardial contractility, ...

• Development of mass spectrometry-based proteome analysis workflows for the systematic study of cardiac disease research models 

  Amedei, Hugo Alejandro (2024-09-26)

  A specific variant of genetic mutation in the phospholamban gene expresses a cardiac phospholamban protein lacking the arginine amino acid at position 14 (R14Δ-PLN). The mutation is believed to have a founder in the ...

• Investigation of the Mitochondria-ER axis and its interconnection with the MICOS complex 

  Wittek, Anna Laura (2024-09-19)

  Mitochondria-ER contact sites (MERCS) are essential cellular hubs for the exchange of signaling molecules, lipids and metabolites. A multitude of MERCS-associated proteins have been described in mammalian cells, and rising ...

• Characterization of Novel Proteins Modulating the Nanoscale Organization of the Membrane-Associated Periodic Skeleton in Neurons 

  Macarrón Palacios, Victor (2024-09-19)

  The Membrane-associated Periodic Skeleton (MPS) is a lattice located underneath the neuronal plasma membrane, characterized by a distinctive ~190 nm periodic architecture imposed by the nanoscale arrangement of its main ...

• Nucleation of Chemically Active Droplets 

  Ziethen, Noah (2024-09-10)

  The interior of a cell is a complicated mixture of many components, and dynamics need to be orchestrated in time and space to ensure the proper functioning of the cell. One key strategy for achieving this tight control is ...

• Investigation of the fusion machinery reconstituted into novel pore-spanning membranes 

  Sari, Merve (2024-09-06)

  The release of neurotransmitter into the synaptic cleft is achieved by fusion of synaptic vesicles with the presynaptic membrane. This essential process in the neuronal signal transmission is driven by the soluble ...

• Characterization of stress-induced cytosolic assemblies containing components of the guided-entry of tail-anchored proteins targeting pathway 

  Jennrich, Jonas (2024-09-04)

  Up to 30% of eukaryotic proteins are integral membrane proteins and need to be targeted to their appropriate membrane locations. The guided entry of tail-anchored proteins (GET) is a key targeting route to the ER membrane ...

• Pairing transcranial direct current stimulation and mindfulness meditation in the treatment of fibromyalgia 

  Ramasawmy, Perianen (2024-08-22)

  The lack of effective treatments for managing pain and associated symptoms in fibromyalgia (FM) poses both a clinical challenge and an economic burden on the health sector. Typical FM therapies include an array of ...

• Tracing evolutionary patterns across the green lineage with respect to protein families and pathways in response to stress 

  Dhabalia Ashok, Amra (2024-08-22)

  The evolutionary history of Chloroplastida is unique, as it includes the emergence of those organisms that make up the macroscopic flora on land: the land plants (embryophytes). The land plants arose from a singular ...

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