Browsing Human- und Zahnmedizin by Advisor & Referee "Nau, Roland Prof. Dr."
Now showing items 21-37 of 37
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Activation of murine microglial cells by muramyl dipeptide alone and in combination with Toll-like receptor agonists
(2014-09-25)Meningitis, meningoencephalitis and sepsis are severe diseases causing many deaths all over the world every year. Escherichia coli (E. coli) is the most common Gram-negative bacterium causing neonatal meningitis and sepsis ... -
Immunreaktionen im zentralen Nervensystem bei Stimulation mit Bestandteilen von Borrelia burgdorferi
(2014-01-06)Stimulation of the CNS in vivo and in vitro with proteins from Borrelia burgdorferi. -
Beeinflussung der Phagozytose von Pneumokokken durch Mikrogliazellen mit Anticholinergika
(2013-12-16)Streptococcus pneumoniae is the most common pathogen causing bacterial meningitis. Despite all efforts using the treatments available, pneumococcal meningitis proves fatal in 25 % of cases. Increasing resistance to ... -
Beeinflussung des Verlaufs von ZNS-Infektionen in immundefizienten Mäusen durch Immunstimulanzien
(2013-10-30)Escherichia coli is the leading cause of Gram-negative meningitis in infants and can also cause meningitis and meningoencephalitis in old and immunocompromised patients. In this doctoral thesis we studied the contribution ... -
Dosisabhängige Aktivierung von Mikrogliazellen durch Toll-like - Rezeptoragonisten allein und in Kombination
(2013-08-22)We investigated the effects of treatment from murine microglial cells with agonists of TLR2, TLR4 and TLR9. For this reason murine microglial cell cultures were applied. We used the TLR agonists Pam3Cys, HKAL (TLR2), ... -
Einfluss einer intrazerebralen Infektion mit Escherichia coli auf den Verlauf der Alzheimer-Demenz im Mausmodell
(2013-06-24)Bacterial infections often worsen the existing neurological symptoms of patients with neurodegenerative diseases such as Alzheimer´s disease. Not only the acute consequences in the sense of a delirium but also the long-term ... -
Regulation der mRNA von Toll-Like-Rezeptoren bei experimentellen ZNS-Infektionen
(2012-11-20)Regulation of the mRNA of toll-like receptors in experimental CNS infections Toll-like receptors are sensors and regulators of innate immunity. We investigated the expression of TLRs in experimental infections with ... -
Quantifizierung der Freisetzung bakterieller DNA in Modellen experimenteller bakterieller Meningitis
(2012-10-25)Bacterial meningitis is still a quite severe illness which is associated with local and systemic inflammation and can cause long-term neurological sequelae or death. Common bacteria causing meningitis in Germany are ... -
Activin A und Follistatin bei bakteriellen Infektionen - Der Einfluss von Activin A auf Mikrogliazellen in vitro und der Einfluss von Follistatin auf den Verlauf einer E. coli-K1-Sepsis im Mausmodell
(2012-10-01)High concentrations of Activin A and Follistatin can be found in the cerebrospinal fluid (CSF) of patients with bacterial meningitis. Patients suffering from a sepsis have increased concentrations of Activin A and Follistatin ... -
Einfluss einer intrazerebralen Infektion mit Streptococcus pneumoniae auf den Verlauf der Alzheimer-Demenz im Mausmodell
(2012-06-18)A well known clinical phenomenon, that has been proved in earlier studies, is the deterioration of the clinical-neurological and neuropsychological status in patients with Alzheimer`s disease (AD). Based on this studies ... -
Additiver Mikroglia-vermittelter Neuronenschaden durch β-Amyloid und bakterielle Toll-like-Rezeptor-Agonisten in primären murinen Mikroglia-Neuronen-Kokulturen. Entwicklung eines Auswertungsalgorithmus zur Quantifizierung des Neuronenschadens mit Hilfe einer Software zur objektorientierten Bildanalyse
(2012-06-06)Activated microglia is considered to be involved in the progression of Alzheimer´s dementia (AD). We investigated the effect of Aβ40 and exogenous agonists of TLR1/2 [Pam3CSK4] and TLR4 [LPS] on neurons in primary ... -
Einfluss systemischer Infektionen und ihrer Behandlungen auf den Krankheitsverlauf im Maus-Modell des Morbus Parkinson
(2011-06-29)Neurodegenrative diseases such as Parkinson s disease are known to be among the prevalent diseases of this kind. Often they tend to deteriorate during acute infections e.g. excited through ... -
Einfluss systemischer Infektionen auf den Krankheitsverlauf der Alzheimer-Erkrankung im Maus-Modell
(2011-04-28)Neurological symptoms of patients suffering from neurodegenerative diseases such as Alzheimer´s dementia often worsen during infections. An experimental approach to this clinical observation ... -
Screening für Demenzen bei Hochaltrigen: Eine Erprobung in Hausarztpraxen
(2010-07-16)Background: The aim of the presented study was to investigate which dementia screening test differentiates best between a "noticeable demented" versus a "non-noticeable demented" population. ... -
Neurogenese und Apoptose im hippokampalen Gyrus dentatus bei Autopsiefällen nach hypoxischem Hirnschaden und Subarachnoidalblutung
(2008-11-26)Hypoxic-ischemic encephalopathy (HIE) is the leading cause of morbidity and mortality after successful resuscitation efforts and results in neuronal loss within the neocortex and the ... -
"Instant Aging"
(2008-02-08)Background: In times of demographic change the treatment of elderly, chronically ill patients becomes a major task for doctors. A teaching method named instant aging was developed in the USA in the seventies. It included ... -
Über die Auswirkungen systemischer bakterieller Begleitinfektionen bei Amyotropher Lateralsklerose
(2007-12-12)Bacterial Infections can aggravate the symptoms in amyotrophic lateral sclerosis probably due to release of bacterial toxins and activation of microglial cells. In the present thesis it is ...