Browsing Human- und Zahnmedizin by Referee "Bickeböller, Heike Prof. Dr."
Now showing items 21-28 of 28
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Erblichkeit in der Aktivität der Enzyme CYP2D6 und CYP2C9 sowie des Transporters OATP1B1 unter Berücksichtigung der bereits bekannten genetischen Varianten
(2014-08-04)BACKGROUND AND OBJECTIVES: It is well accepted that variability in drug responses can be explained by multiple environmental and genetic factors. The individual drug response to the same dose can range from therapy failure ... -
Genetische Polymorphismen und Progressionsgeschwindigkeit der Alzheimer-Demenz
(2013-10-17)Genetic influences are important for the aetiology of Alzheimer's disease (AD). In recent years numerous candidate genes were discovered which showed a significant association with AD in genome-wide association studies ... -
Characterization of Interleukin 10 gene variations and serum levels as predictive factors for the clinical outcome of Non-Hodgkin Lymphoma patients and Analysis of molecular mechanisms of Interleukin 10 gene regulation in B cells
(2013-03-06)Aggressive Non-Hodgkin lymphoma (aNHL) comprises a heterogeneous group of lymphatic malignancies. Although current treatment regiments can achieve high response rates, many patients do not achieve complete remission. ... -
Assessing prediction error of genetic variants in Cox regression models
(2012-04-30)Genetic studies focus on the identification of genetic variants in association with development of disease. Recently, there has been special interest in predicting outcomes based on genetic risk scores and interest in ... -
FLK50-Score zur Vorhersage des Lungenkrebsrisikos bis-50jähriger Probanden. Eine methodische Arbeit auf Basis einer Familienstudie
(2012-01-26)Lung cancer is one of the most common causes of death in Germany. Since the prognosis remains poor, its prevention is of particular significance. Persons at high risk profit most from ... -
Assoziation von Genvarianten aus der Chromosomenregion 5q31-33 mit der Inzidenz von Malaria und Anämie bei Kindern aus Ghana
(2011-11-17)In this work, the 5q31-33 chromosomal region was investigated for genetic associations with the incidence of malaria and anemia in children from Ghana.Variants of the genes interleukin 4 ... -
Zur Risikokalkulation für Mutationen in den Genen BRCA1 und BRCA2 in Familien mit Brustkrebs
(2011-06-24)There are several risk stratifying models for the prediction of mutation carrier probabilities in BRCA1 and BRCA2. Many studies have been carried out evaluating the performance of risk ... -
Der Einfluss des eNOS- Polymorphismus 894 G/T auf das Auftreten und den Schweregrad eines Lungenversagens
(2010-06-07)The purpose of this clinical study is to check whether there is a connection between the appearance as well as the gravity degree of a lung failure and the polymorphism 894 G/ T of the ...