Browsing Human- und Zahnmedizin by Referee "Brockmöller, Jürgen Prof. Dr."
Now showing items 21-30 of 30
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Genetisch bedingte Variabilität der Expression von Genen des TGFß-Signalwegs und deren Bedeutung für die Zellvitalität: Untersuchungen in T-Lymphozyten, immortalisierten B-Lymphozyten und Fibroblasten
(2013-01-29)The TGFbeta pathway is involved in a huge number of biological functions and, hence, relevant for a plethora of clinical disorders. A major function of this pathway is its contribution to fibrotic conditions as it may ... -
Variabilität des Therapieansprechens von Gemcitabin bei Pankreaskarzinom: Identifizierung relevanter Genpolymorphismen
(2013-01-23)Gene polymophisms could play an important role in the variability of therapy response in gemcitabine treated patients with pancreatic carcinoma. The retrospective study showed that a polymorphism in ENT-1, a carrier of ... -
Funktionelle und genetische Variabilität bei der zytotoxischen Wirkung von Nukleosid-Analoga
(2012-04-19)The objekt of this work was the detection of genetic polymorphisms which impact the efficacy of gemcitabine and cytarabine, two nucleoside analogues employed as cytostatic drugs in treatment of cancer. As investigational ... -
Sensitivierung von Sarkomzellen gegenüber Doxorubizin
(2012-04-11)Doxorubicin is one of the most effective cytostatic agents and is widely used in a variety of tumor entities. Despite being one of the drugs of choice in sarcoma treatment, doxorubicin sometimes does not show any ... -
Bedeutung genetischer Polymorphismen in den Genen des Transportproteins SLC6A14, des Leptinrezeptors, des Adiponektins und des Adiponektin-Rezeptors für das Risiko, unter Antipsychotikatherapie Übergewicht zu erleiden
(2012-02-22)In previous studies it was shown that atypical antipsychotic drugs have an important effect on the human energy metabolism. Some patients treated with those drugs suffer from obesity or ... -
ABC-Transporter-Gen-Polymorphismen sind potentielle pharmakogenetische Marker der Ansprechrate auf Mitoxantron in der Behandlung der Multiplen Sklerose
(2012-01-30)Escalation therapy with mitoxantrone (MX) in highly active multiple sclerosis is limited by partially dose-dependent side-effects. Predictors of therapeutic response may result in individualized ... -
Genetische Polymorphismen im Serotonintransportergen und Risikofaktoren für das SIDS (Sudden Infant Death Syndrome)
(2011-11-17)Sudden Infant Death Syndrome (SIDS) is the most common cause of death among infants in the industrialised world. The pathophysiology and causes involved here are still unclear. In recent ... -
Einfluss des Renin-Angiotensin-Systems auf die menschliche Erythropoetinproduktion unter normoxischen Bedingungen und nach Stimulation durch Fenoterol
(2010-11-08)Current evidence suggests that angiotensin II (AT II) is strongly involved as a key transmitter in the regulation of renal erythropoietin (EPO) production. In our study we found a significant ... -
Bedeutung des Cytochrom-P450-2C9- und -3A5-Genpolymorphismus für Pharmakokinetik, Wirkungen und Nebenwirkungen von Delta-9-Tetrahydrocannabinol bei gesunden Probanden und Probandinnen
(2009-06-25)Context: Concerning the consumption of illegal drugs, cannabis (main ingredient Delta-9-THC) has been the most common substance for 30 years in Germany and Europe. Nowadays THC is a subject ... -
Induktion und Differenzierung der proepikardialen Serosa: Analyse einer Vorläuferzellpopulation des embryonalen Herzens
(2007-11-12)The proepicardium is an embryonic precursor cell population, which delivers the epicardium, the cardiac interstitium and all cells of the coronary blood vessels. The proepicardium consists ...