Browsing Human- und Zahnmedizin by Referee "Miosge, Nicolai Prof. Dr."
Now showing items 21-40 of 53
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Die Auswirkungen eines FABP5-Knockdowns in chondrogenen Progenitorzellen
(2017-06-08)Osteoarthritis (OA) is a degenerative disease of the joints in the course of which articular cartilage and surrounding tissues are destroyed. Symptoms range from pain to a complete loss of mobility. Previous therapies aim ... -
Untersuchung zum Wachstums- und Differenzierungsverhalten von humanen mesenchymalen Beckenkammzellen unter dem Einfluss des Überstandes von Damhirschgeweihzellen
(2017-03-10)The annually recurring regeneration of deer antlers, accompanied by rapid growth of around 2 cm per day, is of great interest as a research model due to the structural and histological similarities between antlers and the ... -
Ein Vergleich der Genexpression von humanem oralem periimplantärem Gewebe zwischen Krank und Gesund auf mRNA-Ebene in vivo.
(2017-01-12)Dental implants are now a days a solid part of the modern dentistry in replacing missing teeth. With the rising number of implants inserted, the total number of failure rises as well. The main reason for failure of dental ... -
Induktion der Knochenneubildung durch Implantation von mit rhBMP-2 und VEGF beladenen Polylaktidträgern im ektopen Tiermodell
(2016-12-21)The reconstruction of the facial skeleton after surgical treatment is one of the key procedures in oral and maxillofacial surgery. In this context gold standard is the use of autogenous bone grafts to replace lost tissue ... -
Transfer von Pluripotenzfaktoren maligner Stro-1-positiver und Stro-1 negativer Zellen auf tumorfremde somatische Zellen
(2016-10-18)Despite the fact that a tremendous research effort has been made, the formation, dissemination and the progress of metastatic spread of a tumour disease is not yet entirely understood. However, it is known that so-called ... -
Entwicklung einer Methode zur Bestimmung von Entzündungsmediatoren in Dentinliquor, Dentinspänen und Pulpagewebe von Zähnen mit symptomatischer irreversibler oder reversibler Pulpitis.
(2016-07-22)Aim of the study To develop a method for determination of inflammatory cytokines in the dentinal fluid and dentinal shavings of teeth presenting with symptomatic reversible or irreversible pulpitis. In teeth with irreversible ... -
Porphyromonas gingivalis-induzierte Parodontitis bei Wildtyp-Mäusen und DDR1-Knockout-Mäusen
(2015-09-03)Periodontitis, the chronic inflammatory disease of the periodontium, has taken over caries, the main reason for tooth loss in Germany. To understand the development and the progress of the disease and to achieve therapeutic ... -
Etablierung eines 3D-Tissue-Engineering-Modells zur Bindegewebsherstellung
(2015-08-28)Target: Tissue engineering is a biomedical technology, which has the potential to both repair damaged tissue and to create tissues de novo. There are various different complex methods, which have been previously described ... -
Einfluss von Wachstumsfaktoren auf die Migration von mesenchymalen Progenitorzellen im menschlichen Kniemeniskus
(2015-07-07)Meniscal Progenitor Cells (MPCs) are a newly established group of progenitor cells found in knee menisci of patients suffering from osteoarthritis. This work compares the influence of three growth factors on the migration ... -
Der Einfluss der Überexpression des Enzyms 11-β Hydroxysteroid-Dehydrogenase Typ 1 auf die adipogene Differenzierung von mesenchymalen Vorläuferzellen in vitro
(2015-05-18)Introduction: The differentiation of mesenchymal progenitor cells (MSCs) to the osteoblastic or adipogenic phenotype is thought to be an important pathophysiological mechanism for bone diseases. Dexamethasone induced ... -
Untersuchungen an humanen chondrogenen Progenitorzellen aus späten Stadien der Osteoarthrose zu dem Migrationspotential und der Proliferationsfähigkeit ex vivo sowie zu den Auswirkungen einer Kultivierung in vitro auf das Genexpressionsmuster
(2015-05-18)This study shows the ability for migration and proliferation ex vivo of human chondrogenic progentior cells (CPC) from late stages of osteoarthritis. It also shows that short-time in vitro culture has only small effects ... -
Expressionsanalyse chondrogener Progenitorzellen im ex-vivo Migrationsexperiment
(2015-04-30)The chondrogenic progenitor cells are under control of the expression factors Sox9 and Runx2 favoritising either chondrogenic or osteogenic behavior. In this study we examine the impact on chondrogenic progenitor cells ... -
Therapie osteochondraler Defekte des Kniegelenks unter Verwendung des Knorpel-Knochen-Ersatzmaterials (TruFit®) in Kombination mit einer einzeitigen autologen Knorpelzelltransplantation im Langzeittierversuch
(2015-04-14)Chondral lesions of the knee joint are characterized by a lack of spontaneous regeneration and often result in osteoarthritis. In spite of intensive research there are no alternatives to the current therapies showing a ... -
Expression von SDF-1/CXCL12 und CXCR4 in der sequenziellen DMBA-induzierten Karzinogenese des Hamsters
(2015-03-31)Mutual communication between chemokine stromal-derived-factor 1 (SDF-1/CXCL12) and the corresponding receptor CXCR4 may influence the motility, the tendency toward invasive growth, and the mode of metastasis of tumor cells. ... -
Experimentelle Untersuchung zur Alveolarkammaugmentation mit Trikalziumphosphat-Hydroxylapatit-Komposit eingebettet in eine Poloxamermatrix
(2015-03-23)The aim of this study was to evaluate bone formation in vertical ridge augmentations using a particulate bone grafting material, which was stabilized by a resorbable polymer. In a randomized split-mouth design three ... -
Identifizierung und Charakterisierung von Meniskus Progenitor Zellen (MPCs) bei Osteoarthrose
(2014-05-09)The meniscus plays an important role for the development of osetoathritis in the knee. The regeneration of meniscal tissue after trauma but also chronic cartilage damage is a great problem for medicine because the self-renewal ... -
Knockdown von Runx2 durch RNA-Interference in chondrogenen Progenitor-Zellen
(2014-03-26)The regeneration of diseased hyaline cartilage continues to be a great challenge because its self renewal capacity is limited. In repair tissue from human articular cartilage during the late stages of osteoarthritis ... -
Einfluss von Interleukin 17 auf chondrogene Vorläuferzellen in der rheumatoiden Arthritis
(2014-02-06)Rheumatoid Arthritis is a chronic inflammatory joint disease of still unknown etiology leading to progressive joint destruction. Immunoregulatory cells, synoviocytes and cartilage cells were previously shown to play an ... -
Replikation, Differenzierbarkeit und Proteinausstattung von Klonen chondrogener Progenitorzelllinien
(2014-01-30)Due to the continuously aging global population, the progressive musculoskeletal disease osteoarthritis will, by 2020, be one of the most frequent reasons for invalidity. In 2009, Koelling et al. described a migrating, ... -
Der Einfluss des Transkriptionsfaktors Runx2 auf osteogene und adipogene Differenzierungsmarker, insbesondere auf PPARγ
(2014-01-07)Mesenchymal stem cells can differentiate into osteoblasts, adipocytes, chondrocytes or myoblasts depending on the predominant transcription factor. The influence of Runt-related transcription factor 2 (Runx2) increases ...