Browsing Human- und Zahnmedizin by Referee "Ströbel, Philipp Prof. Dr."
Now showing items 21-37 of 37
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Funktionelle und mechanistische Charakterisierung von EZH2 in Atm-defizienten Subtypen des Pankreaskarzinoms
(2022-11-09)Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second cancer associated cause of death after lung cancer by 2030. The dismal prognosis of PDAC is mainly driven by its resistance towards common cancer therapies ... -
Klinisches Outcome und die prognostische Relevanz von Tumorstammzellmarkern bei Speicheldrüsenmalignomen
(2022-10-07)Salivary gland carcinomas show a low incidence with a broad range of pathological entities and a poor prognosis in the advanced stage, therefore early detection of the disease with a straightforward testing of a biomarker ... -
Proteomische Analyse von Plattenepithelkarzinomen des Kopf-Hals-Bereichs und Plattenepithelkarzinomen der Lunge
(2022-07-26)Patients with squamous cell carcinoma of the head and neck may develop both lung metastasis and metachronous squamous cell carcinoma of the lung due to shared risk factors such as tobacco smoke. Distinguishing between these ... -
Retrospektive Analyse von an der Universitätsmedizin Göttingen (UMG) behandelten Patienten und Patientinnen mit kolorektalen Karzinomen im Zeitraum 2000 bis 2020 und Korrelation der klinischen Parameter mit Proteinanalysen
(2022-06-23)Background: In regard of the Warburg-effect and the progressively more personalised therapy and prognostic options available, based on molecular biology research, the EGFR- and Glycolysis receptor proteins present an ever ... -
Comparative Morphologic and Molecular Classification of Neuroendocrine Tumors of the Thymus in Humans
(2021-04-30)Neuroendocrine tumors (NET) of the thymus are rare neoplasms that share many similarities with their pulmonary counterpart. The WHO 2015 classification of thymic and pulmonary NET divides tumors into typical and atypical ... -
Präklinische Analyse von epithelialen und stromalen Markern in einem transgenen Mausmodell für Pankreaskarzinome
(2021-01-12)Pancreatic ductal adenocarcinoma is amongst the most aggressive cancers and is associated with an extremely poor prognosis. From a histological perspective, pancreatic cancer is char-acterised by a distinct, widespread ... -
Urokinase-type plasminogen activator receptor contributes to chemosensitivity and epithelial-to-mesenchymal transition in PDAC
(2020-10-26)Purpose: Pancreatic ductal adenocarcinoma (PDAC) is the most frequent maliganancy of the pancreas and the fourth most lethal cancer with a 5-year overall survival rate of < 5 %. Patients with a gene amplification in the ... -
Untersuchung spezifischer Inhibitoren der PI3K-Signalkaskade zur Therapie des Lymphangioms
(2020-07-06)Lymphatic malformations (LM; lymphangiomas) are benign congenital malformation disorders of the lymphatic system and are characterized by cystic lymphatic enlargements. A distinction is made between the macrocystic, ... -
Identifizierung von Patientinnen und Patienten mit der hereditären Form des Mamma- und Ovarialkarzinoms mittels Next-Generation-Sequencing-(NGS)-Technologie
(2019-06-11)Breast cancer is the most frequent malignant female cancer. Beside sporadic forms, 5 % - 10 % of these cancers show a hereditary origin with an identified germline mutation. The main purpose of this study was to analyse ... -
Experimentelle genetische und proteomische Identifikation von diagnostischen und prognostischen Biomarkern epithelialer Thymustumoren
(2019-03-07)Thymomas and thymic carcinomas are the most common primary mediastinal tumors of the adult. Therapy strategies of thymic epithelial tumors are based on the histological WHO classification. Reviews pictured the low ... -
uPAR und c-MYC beim duktalen Adenokarzinom des Pankreas
(2018-08-16)The dismal prognosis of pancreatic cancer is closely related to aggressive tumor development that leads to diagnosis in advanced stages and limited curative concepts. Urokinase-type plasminogen activator receptor (uPAR) ... -
FRET-Bildgebung zum Nachweis der Phopshorylierung der anaplastic lymhoma kinase (ALK) im nicht-kleinzelligen Bronchialkarzinom
(2018-05-22)Background: Anaplastic lymphoma kinase (ALK) is an oncogenic driver mutation in T-cell lymphoma and NSCLC. Small molecule inhibitors are available. Treatment decisions are mostly made on ALK expression but their efficacy ... -
Zytogenetische und klinische Verläufe von älteren Patienten mit fortgeschrittenem MDS unter alleiniger 5-Azacytidin-Therapie im Vergleich zur Therapie mit 5-Azacytidin gefolgt von allogener Stammzelltransplantation
(2018-05-11)Myelodysplatic syndrome are defined as a group of heterogeneous, clonal hematopoietic diseases characterised by ineffective haematopoiesis, with an increased risk to undergo transformation into acute myelogenous leukaemia. ... -
Zur Phänomenologie des Obduktionsguts der Rechtsmedizin Göttingen 1969 - 1978 und 1998 - 2007
(2016-11-01)Changes in our society may potentially lead to shifts in the profile of forensic autopsies. A retrospective evaluation of autopsy protocols (nges= 5.190) at the Insitute of Legal Medicine Göttingen was performed, comparing ... -
Molekularpathologie seltener Sarkomentitäten des Urogenitaltraktes
(2013-11-07)Soft tissue sarcomas of the genito-urinary tract are really rare and aggressive tumors with rapid tumor progression and early metastatic disease. Despite the histological similarity of these small-, round- and blue cell ... -
Der HER-2-Status im lokal fortgeschrittenen Rektumkarzinom: Positivitätsrate, mögliche prädiktive und prognostische Bedeutung
(2013-08-26)In patients with advanced rectal cancer (cUICC II and III) multimodality therapy resulted in better long-term local tumor control. Ongoing clinical trials are focusing on therapy intensification to improve disease-free ... -
Etablierung der Organotypischen Hirnschnitt-Kokultur als Tumor-Invasionsmodell
(2013-02-12)The aim of this study is to contribute significantly to our understanding of cerebral metastasis formation. The process of the metastatic site has barely been investigated yet, in particular the role of resident cells. It ...