Browsing Human- und Zahnmedizin by Title
Now showing items 1324-1343 of 3000
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Identification and characterization of the molecular complex formed by the P2X<sub>2</sub> receptor subunit and the adapter protein Fe65 in rat brain
(2006-06-29)Synaptic transmission in the nervous system is achieved through the release of neurotransmitters from presynaptic terminals, resulting in the activation of neurotransmitter receptors at ... -
Identification and functional characterisation of oncogenic pathway signatures in malignant lymphoma
(2012-01-17)B cell aggressive non-Hodgkin lymphomas (aNHL) represent a heterogeneous group of lymphatic malignancies comprising Burkitt Lymphoma (BL) and Diffuse Large B cell lymphoma (DLBCL). aNHL ... -
Identification and Functional Characterization of Novel Ionotropic Glutamate Receptor Subunits at Drosophila Neuromuscular Synapse
(2005-02-11)The molecular mechanisms triggering the formation of synapses in vivo are crucial for understanding the development as well as the activity dependent remodelling of synaptic circuits. ... -
Identification of biomarker-defined populations in precision medicine
(2023-03-24)The aim of precision medicine is to identify the treatment that provides the best response for a patient. For this purpose, predictive biomarkers play a crucial role. Due to their ability to define subgroups of patients ... -
Identification of microRNA 302 as an antagonist to p63 expression
(2009-12-18)The p53-family of transcription factors is essential in tumor-suppression, during development and in tissue homeostasis. MicroRNAs are small single-stranded RNAs involved in translation ... -
Identification of Prognostically Relevant Cellular Markers of Differentiation in Glioblastoma
(2016-09-28)Introduction: Glioblastoma multiforme is the most common primary brain tumor. Despite intense research efforts worldwide, the prognosis of patients diagnosed with this tumor remains poor. Several clinical and molecular ... -
Identification of the molecular role of Pelota protein (PELO) by analysis of conditional Pelo-knockout mice
(2017-01-09)The skin acts as a first protective barrier that diminishes the fluid loss from the body and prevents the entry of toxic and pathogenic agents. Defect in the formation of the epidermal barrier results in neonatal lethality ... -
Identifikation einer funktionellen Kernerkennungssequenz in der Dual-Leucine-Zipper-Bearing Kinase
(2010-08-03)Proinflammatory cytokines could be involved in the reduction of functional beta-cell loss in the prediabetic state. These cytokines lead to an activation of the MAP-Kinase path and JNK which ... -
Die Identifikation transkriptioneller Biomarker für periphere Polyneuropathien
(2024-09-24)Peripheral polyneuropathies are a heterogeneous group of widespread diseases of the peripheral nerves that can be caused by numerous factors. Differentiating between different types of polyneuropathies and identifying their ... -
Identifikation und Analyse von Interaktionen Erreger-spezifischer Antikörper mit Proteinen des fötalen Gehirns
(2023-12-11)Schizophrenic disorders affect approximately 1% of the global population and are associated with a significant impairment of mental and physical health. To date, similar to many other neuropsychiatric disorders, there is ... -
Identifikation und Charakterisierung von Typ-II-Neuroblasten im Embryo des Mehlkäfers Tribolium castaneum
(2024-08-16)Evolution has created a wide range of morphological diversity in insect brains, while the basic structure is conserved. Little is known about the mechanisms that lead to this evolutionary diversification of similar structures. ... -
Identifikation und funktionelle Charakterisierung von TMPRSS2-Spaltstellen im Spike-Protein des SARS-Coronavirus
(2017-04-24)The severe acute respiratory syndrome coronavirus (SARS-CoV) is an emerging pathogen, which poses a substantial threat to human health. The viral surface protein spike (SARS-S) mediates viral entry into target cells. The ... -
Identifizierung genetischer Biomarker für die Wirksamkeit von Oxaliplatin:Kandidatengen-bezogene und Genom-weite Analysen
(2014-11-28)Oxaliplatin is an anticancer drug used to treat advanced and metastatic stages of colorectal carcinoma. In patients, different treatment responses can be observed suggesting an impact of germline genetic variability. ... -
Identifizierung potentieller Onkogene und therapeutischer Zielgene auf Chromosom 13q beim Kolonkarzinom
(2013-01-29)Colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances accumulating during tumor progression. Among others, chromosome 13q is frequently gained. However, the genes representing targets of ... -
Identifizierung und Charakterisierung des Effektorproteins CPn1020 von <i>Chlamydophila pneumoniae</i>
(2006-08-08)Chlamydophila pneumoniae is an obligate intracellular bacterial pathogen of acute respiratory tract infections, responsible for about 10 % of community acquired pneumonia cases worldwide. ... -
Identifizierung und Charakterisierung von Meniskus Progenitor Zellen (MPCs) bei Osteoarthrose
(2014-05-09)The meniscus plays an important role for the development of osetoathritis in the knee. The regeneration of meniscal tissue after trauma but also chronic cartilage damage is a great problem for medicine because the self-renewal ... -
Identifizierung und funktionelle Charakterisierung von vegetal lokalisierten RNAs in der Xenopus laevis Oozyte
(2002-08-28)The subcellular localization of mRNA molecules is an important mechanism for regulating gene expression at the post-transcriptional level. In Xenopus laevis oocytes, vegetally localized ... -
Identifizierung von Biomarkern für die Prognose der Gemcitabin-Therapie beim Pankreaskarzinom: RNA-, DNA- und Immunhistochemische- Analysen
(2015-02-06)One aim of this study was to investigate the associations of genetic polymorphisms in the genes involved in gemcitabine pathways and the cinical outcome of patients with pancreatic ductal adenocarcinoma. A nucleoitide ... -
Identifizierung von In-vivo Interaktionspartnern von PMP22 im peripheren Nerven der Ratte
(2023-03-20)The most common hereditary neuropathy, Charcot-Marie-Tooth disease type 1A (CMT1A), is caused by a duplication of the gene coding for the peripheral myelin protein 22 (PMP22). Despite long lasting scientific investigations, ... -
Identifizierung von neuen Komponenten oder Cargoes der COPI Vesikelhüll Maschinerie
(2021-03-26)Within the cell transport vesicles play an essential role in ensuring the functionality of the cell. The heptamere COPI is responsible for transport from the Golgi to the endoplasmic reticulum and also for transport between ...