Browsing Human- und Zahnmedizin by Title
Now showing items 1156-1175 of 3138
-
Experimentelle Untersuchungen zum neuroprotektiven Einfluss von endogenem Faim2 im murinen Fadenokklusionsmodell der zerebralen Ischämie
(2013-11-28)Apoptosis plays a major role in neurological development, differentiation and diseases. After being activated through Fas-ligands, the death receptor Fas/CD95 initiates a caspase cascade, leading to apoptosis. The activation ... -
Experimentelle Untersuchungen zur Strahlenempfindlichkeit von Lymphozyten bei Patienten mit lokal fortgeschrittenem Rektumkarzinom
(2017-03-08)A neoadjuvant radio –and chemotherapie as standard of the multimodal treatment of the locally advanced rectal cancer causes damages of the DNA that can be detected in peripheral blood lymphocytes (PBL). After acquisition ... -
Experimentelles Neurotrauma im Mausmodell
(2005-01-12)Even mild headtrauma can induce persisting and clinically relevant symptoms in men. This thesis deals with the lesion-specific characteristics of a model for neurotrauma in mice regarding ... -
Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis
(2014-01-21)Recent studies have shown a decrease in annualized relapse rates (ARRs) in placebo groups of randomized controlled trials (RCTs) in relapsing multiple sclerosis (RMS). This dissertation aimed to describe this trend ... -
Exploration medizinethischer Implikationen individualisierter Medizin beim lokal fortgeschrittenen Rektumkarzinom aus Sicht von Ärzten und Forschern - eine empirisch-ethische Untersuchung
(2014-06-30)So-called individualized medicine is an emerging concept in clinical research and clinical practice. We conducted a social-empirical interview study with members of a leading German clinical research group (KFO 179) about ... -
Exploring the role of Cytoglobin (CYGB) in melanoma pathobiology
(2025-01-17)Skin cancer is one of the most common malignancies worldwide, with melanoma being the deadliest form. Although both targeted therapies inhibiting the MAPK pathway and immunotherapy have improved the prognosis of patients ... -
Expression der kostimulatorischen Moleküle ILA (CD137) und ICOS (CD278) sowie ihrer Liganden auf Mastzellen und T-Zellen der Haut von Patienten mit Psoriasis vulgaris
(2011-11-02)In this study the expression of the co-stimulatory molecules ILA receptor (ILA, "induced by lymphocyte activation", CD137 in humans and 4-1BB in mice) from the TNF receptor family and ICOS ... -
Expression des ABC-Transporters ABCA3 in Zellen der physiologischen Hämatopoese und in maligne transformierten lymphatischen Zellen
(2007-10-30)Drug resistance is still a major issue in the treatment of hematological malignancies, and ATP-binding-cassette (ABC)-transporters contribute to it by active efflux of cytostatic drugs. The ... -
Expression des epidermalen Wachstumsfaktorrezeptors Her2/neu in Rektumkarzinomen des lokal fortgeschrittenen Stadiums UICC II / III - Validierung an Patienten der Phase-III-Studien der German Rectal Cancer Study Group
(2016-08-22)Validation of the frequency of the expression of her2/neu in rectal cancer. Her2/neu is an epidermal growth factor receptor known from breast or oesophagus cancer and thought to be a possible therapy target in rectal cancer. -
Expression des Gonadotropin-Releasing-Hormon (GnRH)-Rezeptors in primären humanen Osteoblasten und Effekte des GnRH-Agonisten Triptorelin auf die Expression osteoblastärer Gene
(2010-03-29)In addition to its function as a key hormone in the regulation of the pituitary-gonadal axis, gonadotropin-releasing hormone (GnRH) affects a variety of human extrapituitary tissues such ... -
Expression humaner Angiogenesefaktoren in der Plazenta präeklamptischer Patientinnen
(2020-03-23)Preeclampsia is a disease that can occur during pregnancy after 20 weeks of gestation. It is characterized by cardinal symptoms of hypertension > 140/90 mmHg and proteinuria > 300 mg / 24 h. Since preeclampsia can affect ... -
Expression of gemcitabine metabolizing enzymes in different pancreatic cancer model systems
(2023-03-23)Pancreatic cancer still exhibits a dismal five-year overall survival rate of 9 % and is foreseen to even increase in incidence and mortality rates in the future. This is due to unspecific symptoms leading to late diagnosis, ... -
Expression spannungsabhängiger Hirntyp-Natriumkanäle im sich entwickelnden Myokard der Ratte
(2013-11-05)Voltage gated sodium channels (VGSC) conduct the sodium current responsible for the rapid upstroke of the myocardial action potential. SCN5A is the VGSC mainly expressed in the heart. Mutations of SCN5A result in severe ... -
Expression und Funktion des Vitamin-D-Rezeptors in malignen Keimzelltumoren des Hodens
(2011-02-25)Testicular germ cell tumours (TGCT) are the most common malignancy in young men. They are clinical and histological subdivided in seminomas and non-seminomas. 1,25-dihydroxyvitamin D3 ... -
Expression und Wirkungsmechanismen von Gonadotropin-Releasing Hormon Typ II (GnRH-II) und seines Rezeptors in humanen Ovarial- und Endometriumkarzinomen
(2006-07-13)The majority of human endometrial- (>80%) and ovarian (>80%) cancer cell lines express gonadotropin releasing hormone (GnRH-I) and its receptor as a part of a negative autocrine/paracrine ... -
Expression von Genen des WNT-Signalwegs in humanen Makrophagen nach MCF-7 Ko-Kultivierung und in murinen Makrophagen nach Mikrovesikel-Stimulation
(2019-09-19)The interaction between malignant cells and stroma cells contributes in a crucial way to their biological activity. In breast cancer there is an association between activation of the canonical WNT-Pathway and aggressive ... -
Die Expression von High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) als Pathomechanismus der sporadischen Einschlusskörpermyositis
(2009-11-20)Sporadic inclusion body myositis (sIBM) is a chronic progressive muscle disease. In the tissue of sIBM patients degenerative molecules, inflammatory cells and cell stress molecules are ... -
Expression von HLA-Molekülen in humanen Monozyten in Abhängigkeit von Toxoplasma gondii-Infektionen
(2013-05-13)Toxoplasma gondii is an obligate intracellular protozoan parasite which infects a broad range of mammalian and avian hosts and which leads to lifelong persisting infections in humans and animals. For long-term survival in ... -
Expression von Lymphotaktin (XCL1) bei der Wegener'schen Granulomatose
(2012-03-27)OBJECTIVE: In Wegener's granulomatosis (WG), vasculitic lesions are characterized by prominent infiltration of polymorphonuclear neutrophils (PMN) and T cells, but underlying ... -
Expression von Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) in Blasten von Patienten mit akuter myeloischer Leukämie
(2011-06-20)Acute myeloid leukemia is a hematologic malignancy with fatal outcome within days or weeks if untreated. Even in the time of optimized, risk factor chemotherapy regimens for remission ...