Browsing Human- und Zahnmedizin by Title
Now showing items 1160-1179 of 3177
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Experimental imaging of asthma progression and therapeutic response in mouse lung models
(2015-11-03)Mouse models have been a versatile tool in asthma research, however the application of imaging techniques to quantify hallmarks of asthma, to follow the course of the disease or to monitor treatment response are hampered ... -
Experimental study of the combined effect of irradiation, lovastatin, and monoclonal antibodies on tumour and normal tissue cell lines. Its genesis and mechanisms of action
(2014-09-30)Statins, as lipid-lowering agents, were described to possess an anti-cancer potential. For this reason, in vitro effect of combined treatment by lovastatin and irradiation was explored in order to find a radiosensitizing ... -
Experimental therapy with progesterone on a mouse model for hereditary neuropathy with liability to pressure palsies (HNPP)
(2020-02-26)Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant demyelinating disorder characterized by episodic, recurrent peripheral sensory and motor neuropathies, triggered by minor traumas or ... -
Experimentelle genetische und proteomische Identifikation von diagnostischen und prognostischen Biomarkern epithelialer Thymustumoren
(2019-03-07)Thymomas and thymic carcinomas are the most common primary mediastinal tumors of the adult. Therapy strategies of thymic epithelial tumors are based on the histological WHO classification. Reviews pictured the low ... -
Experimentelle Therapie eines Mausmodells für die Pelizaeus-Merzbacher-Erkrankung mit Lonaprisan und Curcumin
(2023-06-05)Pelizaeus-Merzbacher disease (PMD) is a severe x-linked leukodystrophy caused, in the majority of cases, by a duplication of Plp1 coding for Proteolipid Protein. Using a PMD mouse model carrying additional copies of ... -
Experimentelle Therapie eines transgenen Tiermodells der Charcot-Marie-Tooth-Krankheit mit Meriva-Curcumin und Cholesterol
(2017-06-06)The charcot marie tooth disease is the most frequent type of hereditary myelinating disorders of the peripheral nervous system in the human race. Caused by a myelin gene duplication of the PMP22-Gen, the expression level ... -
Experimentelle und klinische Untersuchung der elektrischen Impedanztomographie zur regionalen Lungenfunktionsprüfung beatmeter Patienten
(2007-02-21)Atelectasis are typical in patients with acute lung injury and intrapulmonary shunt is correlated with the amount of these atelectasis. The goal of each mechanical ventilation is to prevent ... -
Experimentelle Untersuchung zur Alveolarkammaugmentation mit Poly-(D,L-)Laktid-Membranen
(2015-03-02)The objective of this experimental investigation was to assess the regeneration of alveolar bone defects using a rigid synthetic barrier system (PDLLA) in a shell technique with natural bone mineral (NBM) respectively a ... -
Experimentelle Untersuchung zur Alveolarkammaugmentation mit Trikalziumphosphat-Hydroxylapatit-Komposit eingebettet in eine Poloxamermatrix
(2015-03-23)The aim of this study was to evaluate bone formation in vertical ridge augmentations using a particulate bone grafting material, which was stabilized by a resorbable polymer. In a randomized split-mouth design three ... -
Experimentelle Untersuchung zur Auswirkung für Kopf-Hals-Tumoren relevanter Strahlendosen auf das Randschlussverhalten von Amalgam- und Kunststoff-Füllungen
(2016-06-14)In a standardized and randomized process bovine teeth were subject to the preparation and filling of cavities with amalgam and composite and afterwards were irradiated with radiation doses of 60 Gray and 90 Gray. The ... -
Experimentelle Untersuchung zur Wirkung von in Tumorzellen produziertem Keratinozytenwachstumsfaktor (KGF) auf die proliferative Aktivität und Strahlenreaktion von Tumoren und Normalgewebe
(2011-03-07)Purpose of this work was to test the effect of tumour-cell-derived keratinocyte growth factor (KGF) or recombinant KGF (palifermin) on cell proliferation and radiation response of human ... -
Experimentelle Untersuchungen zum neuroprotektiven Einfluss von endogenem Faim2 im murinen Fadenokklusionsmodell der zerebralen Ischämie
(2013-11-28)Apoptosis plays a major role in neurological development, differentiation and diseases. After being activated through Fas-ligands, the death receptor Fas/CD95 initiates a caspase cascade, leading to apoptosis. The activation ... -
Experimentelle Untersuchungen zur Strahlenempfindlichkeit von Lymphozyten bei Patienten mit lokal fortgeschrittenem Rektumkarzinom
(2017-03-08)A neoadjuvant radio –and chemotherapie as standard of the multimodal treatment of the locally advanced rectal cancer causes damages of the DNA that can be detected in peripheral blood lymphocytes (PBL). After acquisition ... -
Experimentelles Neurotrauma im Mausmodell
(2005-01-12)Even mild headtrauma can induce persisting and clinically relevant symptoms in men. This thesis deals with the lesion-specific characteristics of a model for neurotrauma in mice regarding ... -
Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis
(2014-01-21)Recent studies have shown a decrease in annualized relapse rates (ARRs) in placebo groups of randomized controlled trials (RCTs) in relapsing multiple sclerosis (RMS). This dissertation aimed to describe this trend ... -
Exploration medizinethischer Implikationen individualisierter Medizin beim lokal fortgeschrittenen Rektumkarzinom aus Sicht von Ärzten und Forschern - eine empirisch-ethische Untersuchung
(2014-06-30)So-called individualized medicine is an emerging concept in clinical research and clinical practice. We conducted a social-empirical interview study with members of a leading German clinical research group (KFO 179) about ... -
Exploring the role of Cytoglobin (CYGB) in melanoma pathobiology
(2025-01-17)Skin cancer is one of the most common malignancies worldwide, with melanoma being the deadliest form. Although both targeted therapies inhibiting the MAPK pathway and immunotherapy have improved the prognosis of patients ... -
Expression der kostimulatorischen Moleküle ILA (CD137) und ICOS (CD278) sowie ihrer Liganden auf Mastzellen und T-Zellen der Haut von Patienten mit Psoriasis vulgaris
(2011-11-02)In this study the expression of the co-stimulatory molecules ILA receptor (ILA, "induced by lymphocyte activation", CD137 in humans and 4-1BB in mice) from the TNF receptor family and ICOS ... -
Expression des ABC-Transporters ABCA3 in Zellen der physiologischen Hämatopoese und in maligne transformierten lymphatischen Zellen
(2007-10-30)Drug resistance is still a major issue in the treatment of hematological malignancies, and ATP-binding-cassette (ABC)-transporters contribute to it by active efflux of cytostatic drugs. The ... -
Expression des epidermalen Wachstumsfaktorrezeptors Her2/neu in Rektumkarzinomen des lokal fortgeschrittenen Stadiums UICC II / III - Validierung an Patienten der Phase-III-Studien der German Rectal Cancer Study Group
(2016-08-22)Validation of the frequency of the expression of her2/neu in rectal cancer. Her2/neu is an epidermal growth factor receptor known from breast or oesophagus cancer and thought to be a possible therapy target in rectal cancer.