Browsing Human- und Zahnmedizin by Title
Now showing items 1176-1195 of 3172
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Expression des ABC-Transporters ABCA3 in Zellen der physiologischen Hämatopoese und in maligne transformierten lymphatischen Zellen
(2007-10-30)Drug resistance is still a major issue in the treatment of hematological malignancies, and ATP-binding-cassette (ABC)-transporters contribute to it by active efflux of cytostatic drugs. The ... -
Expression des epidermalen Wachstumsfaktorrezeptors Her2/neu in Rektumkarzinomen des lokal fortgeschrittenen Stadiums UICC II / III - Validierung an Patienten der Phase-III-Studien der German Rectal Cancer Study Group
(2016-08-22)Validation of the frequency of the expression of her2/neu in rectal cancer. Her2/neu is an epidermal growth factor receptor known from breast or oesophagus cancer and thought to be a possible therapy target in rectal cancer. -
Expression des Gonadotropin-Releasing-Hormon (GnRH)-Rezeptors in primären humanen Osteoblasten und Effekte des GnRH-Agonisten Triptorelin auf die Expression osteoblastärer Gene
(2010-03-29)In addition to its function as a key hormone in the regulation of the pituitary-gonadal axis, gonadotropin-releasing hormone (GnRH) affects a variety of human extrapituitary tissues such ... -
Expression humaner Angiogenesefaktoren in der Plazenta präeklamptischer Patientinnen
(2020-03-23)Preeclampsia is a disease that can occur during pregnancy after 20 weeks of gestation. It is characterized by cardinal symptoms of hypertension > 140/90 mmHg and proteinuria > 300 mg / 24 h. Since preeclampsia can affect ... -
Expression of gemcitabine metabolizing enzymes in different pancreatic cancer model systems
(2023-03-23)Pancreatic cancer still exhibits a dismal five-year overall survival rate of 9 % and is foreseen to even increase in incidence and mortality rates in the future. This is due to unspecific symptoms leading to late diagnosis, ... -
Expression spannungsabhängiger Hirntyp-Natriumkanäle im sich entwickelnden Myokard der Ratte
(2013-11-05)Voltage gated sodium channels (VGSC) conduct the sodium current responsible for the rapid upstroke of the myocardial action potential. SCN5A is the VGSC mainly expressed in the heart. Mutations of SCN5A result in severe ... -
Expression und Funktion des Vitamin-D-Rezeptors in malignen Keimzelltumoren des Hodens
(2011-02-25)Testicular germ cell tumours (TGCT) are the most common malignancy in young men. They are clinical and histological subdivided in seminomas and non-seminomas. 1,25-dihydroxyvitamin D3 ... -
Expression und Wirkungsmechanismen von Gonadotropin-Releasing Hormon Typ II (GnRH-II) und seines Rezeptors in humanen Ovarial- und Endometriumkarzinomen
(2006-07-13)The majority of human endometrial- (>80%) and ovarian (>80%) cancer cell lines express gonadotropin releasing hormone (GnRH-I) and its receptor as a part of a negative autocrine/paracrine ... -
Expression von Genen des WNT-Signalwegs in humanen Makrophagen nach MCF-7 Ko-Kultivierung und in murinen Makrophagen nach Mikrovesikel-Stimulation
(2019-09-19)The interaction between malignant cells and stroma cells contributes in a crucial way to their biological activity. In breast cancer there is an association between activation of the canonical WNT-Pathway and aggressive ... -
Die Expression von High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) als Pathomechanismus der sporadischen Einschlusskörpermyositis
(2009-11-20)Sporadic inclusion body myositis (sIBM) is a chronic progressive muscle disease. In the tissue of sIBM patients degenerative molecules, inflammatory cells and cell stress molecules are ... -
Expression von HLA-Molekülen in humanen Monozyten in Abhängigkeit von Toxoplasma gondii-Infektionen
(2013-05-13)Toxoplasma gondii is an obligate intracellular protozoan parasite which infects a broad range of mammalian and avian hosts and which leads to lifelong persisting infections in humans and animals. For long-term survival in ... -
Expression von Lymphotaktin (XCL1) bei der Wegener'schen Granulomatose
(2012-03-27)OBJECTIVE: In Wegener's granulomatosis (WG), vasculitic lesions are characterized by prominent infiltration of polymorphonuclear neutrophils (PMN) and T cells, but underlying ... -
Expression von Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) in Blasten von Patienten mit akuter myeloischer Leukämie
(2011-06-20)Acute myeloid leukemia is a hematologic malignancy with fatal outcome within days or weeks if untreated. Even in the time of optimized, risk factor chemotherapy regimens for remission ... -
Expression von polyspezifischen Transportern in renalen Tumoren und ihre Bedeutung für die Chemotherapie
(2008-03-25)Renal cancer cell carcinoma (RCC) is usually chemoresistant. This chemoresistance would be overcome when a cytostatic is applied for which the RCC possesses an uptake transporter. In the present study I investigated the ... -
Expression von pro- und antiinflammatorischen Zytokinen in Kupfferzellen der Rattenleber unter Normal- und Entzündungsbedingungen
(2006-11-29)Lipopolysaccharides (LPS) as triggers of inflammation play an important role in the regulation of hepatic defence. The resident Kupffer cells (KC) of the liver respond directly to LPS by ... -
Expression von RANK / RANKL im Harnblasenkarzinom
(2015-12-03)Background: Bladder cancer causes significant health restrictions and burdens as a common disease, especially among men. The third most common localization for metastases of bladder cancer is the bone which often causes ... -
Expression von SDF-1/CXCL12 und CXCR4 in der sequenziellen DMBA-induzierten Karzinogenese des Hamsters
(2015-03-31)Mutual communication between chemokine stromal-derived-factor 1 (SDF-1/CXCL12) and the corresponding receptor CXCR4 may influence the motility, the tendency toward invasive growth, and the mode of metastasis of tumor cells. ... -
Die Expression von SRC vor und nach neoadjuvanter Radiochemotherapie im lokal fortgeschrittenen Rektumkarzinom cUICC II/III.
(2016-01-12)Purpose: SRC, one of the oldest proto-oncogenes, is encoding for the tyrosine kinase of the same name. The protein, which is localized in the cytosol as well as in the cell membrane, is involved in cell proliferation and ... -
Die Expression von Sulfattransportern als Funktion einer fortschreitenden Nierenfibrose am Modell der Alport-Maus
(2012-01-13)The system of sulfate metabolism and the expression of sulfate transporters in kidney and liver tissue are influenced by various parameters. The focus of this thesis lies on the sulfate ... -
Expressionsanalyse chondrogener Progenitorzellen im ex-vivo Migrationsexperiment
(2015-04-30)The chondrogenic progenitor cells are under control of the expression factors Sox9 and Runx2 favoritising either chondrogenic or osteogenic behavior. In this study we examine the impact on chondrogenic progenitor cells ...