Browsing Human- und Zahnmedizin by Title
Now showing items 1843-1862 of 3249
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Mausmodell der Einschlusskörpermyositis: Pathophysiologie des Muskels nach knock-down der induzierbaren Stickstoffmonoxid-Synthase (iNOS)
(2017-04-26)The inclusion body myositis is the most frequent acquired myopathy of the patient collective beyond the age of 55, and is largely unknown in its multifactorial pathogenesis. Conditions which accelerate or diminish the ... -
Mean Age and Gender Distribution of Patients with Mental Disorders in Randomized Controlled Studies
(2019-05-13)The mean age and gender distribution of patients seeking help for mental disorders have not yet been investigated systematically. Epidemiological surveys can provide data on gender distribution of disorders and an age range ... -
Mechanische Rekanalisation bei akutem ischämischen Schlaganfall durch Aspirationsthrombektomie mit dem Penumbra System
(2013-06-03)BACKGROUND AND PURPOSE: The Penumbra System is an innovative mechanical device designed to recanalize large-vessel occlusions by thrombus aspiration. The purpose of this study was to evaluate the effectiveness and neurologic ... -
Mechanism of pFGE and FGE Retention in Endoplasmic Reticulum
(2007-03-05)The formylglycine generating enzyme FGE, encoded by SUMF1 gene (Sulfatase modifying factor 1) performs a novel co-translational modification of a specific cysteine residue to formylglycine ... -
Mechanismen der Belasstungseinschränkung von Patienten mit diastolischer Herzinsuffizienz im vergleich zu Patienten mit diastolischer Dysfunktion unter besonderer Berücksichtigung der neurohumoralen Aktivierung
(2011-09-30)Background: Patients with diastolic dysfunction (DD) and diastolic heart failure (DHF) are known to suffer from reduced exercise capacity. However, there is only limited knowledge about ... -
Mechanismen der Tachykardie-induzierten Kardiomyopathie im humanen Myokard und Kardiomyozyten
(2025-04-14)Tachycardia-induced cardiomyopathy (TCM) describes a reversible form of left-ventricular dysfunction based on a persisting tachycardia. Its clinical impact is relevant but often underestimated, hence its mechanisms remain ... -
Mechanismen der Tumorsuppression und Resistenzüberwindung einer therapeutischen GSK-3β- Inhibition im Pankreaskarzinom
(2025-02-17)Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of human cancer with a five-year survival of only 11%. Recent studies have shown that PDAC results from a successive accumulation of different ... -
Mechanismen der Urocortin-II-induzierten Stimulation der NO-Produktion in isolierten Kaninchen-Ventrikelmyozyten
(2009-08-11)Urocortin II (UcnII), a peptide from corticotropin-releasing factor (CRF) family, is exhibiting beneficial effects in heart failure. In cardiomyocytes, it elicits a cAMP- and Ca2+-dependent ... -
Mechanismen Isoprenalin-induzierter Extrakontraktionen im humanen Vorhofmyokard
(2012-07-27)Defective regulation of Ca2+-homeostasis and, more particularly, the release of Ca2+ through the ryanodine receptor (RyR2) of the sarcoplasmic reticulum plays a crucial role in the occurrence of cardiac arrhythmias. The ... -
Mechanismus der Neuentstehung von Peroxisomen in Saccharomyces cerevisiae
(2010-02-01)In this thesis, it was tried to investigate the mechanisms of the new formation of peroxisomes, i.e. whether precursors of peroxisomes mature or whether they merge with each other. To clarify ... -
Mechanismus von Glukokortikoiden in der Regulation des Immunmetabolismus humaner T-Zellen
(2025-01-20)Glucocorticoids are used to treat numerous inflammatory diseases. But despite decades of research, their exact mechanisms of action remain incompletely understood. Glucocorticoids influence the activity and effector functions ... -
Medikamentöse Defibrinogenierung zur Behandlung des akuten Hörverlustes – eine verblindete, placebokontrollierte In-vivo-Studie
(2020-11-26)Sudden hearing loss is one of the most common inner-ear diseases. The underlying pathomechanism is still not fully understood and most often it remains idiopathic. One of its discussed causes is the disturbance of cochlear ... -
Medizinethik im Spiegel der Zeitschrift „Arzt und Christ“
(2018-02-08)This dissertation uncovers the history of the journal “Arzt und Christ” from its first volume in 1955 to 1993 when it was renamed “Zeitschrift für medizinische Ethik”. The aim is to show the journal’s contribution to the ... -
Medizinethische Aspekte der fallpauschalisierten Abrechnung im deutschen Krankenhauswesen
(2010-10-25)Since 2004 there is a new reimbursement system in German hospitals called DRGs (diagnosis related groups). This thesis deals with changes in the quality of treatment of patients with ... -
Die medizinische Betreuung von Pflegeheimbewohnern
(2016-11-30)Introduction: The rising number of persons needing care is increasingly being catered for by means of in-patient facilities in Germany. This growth brings new challenges with it, not least where medical care for the ... -
Medulloblastome im Kindes- und Jugendalter im Zeitraum von 1989 bis 2015
(2022-02-22)Medulloblastoma is the most common malignant brain tumor in children and adolescents and its therapy is still difficult due to the vulnerability of the child's brain. Medulloblastomas arise in the posterior fossa of the ... -
Membranprotein-Komposition von Kardiofibroblasten in Normoxie und Hypoxie
(2019-10-08)Hypoxia is a key element in the pathophysiology of ischemic, inflammatory and malignant neoplastic diseases. It also plays an essential role in the intrauterine environment during embryonic development as well as in stem-cell ... -
Membrantransport von Substanzen mit ZNS-Wirkungen oder Nebenwirkungen über organische Kationentransporter
(2025-02-28)In addition to simple diffusion, carrier-mediated transport represents one possibility of exchange across the blood-brain barrier. This enables selective transport across membranes and plays an essential role in the specific ... -
Meningeosis neoplastica: Der Einfluss von Tumorart und Liquorzellzahl auf die Diagnostik
(2016-07-26)Background. Although CSF cytology and MRI are standard methods to diagnose neoplastic meningitis (NM), this complication of neoplastic disease remains difficult to detect. We therefore reevaluated the sensitivity of ... -
Mesenchymale Stammzellen der Kopf-Hals-Region im Fokus der Reprogrammierung in induzierte pluripotente Stammzellen und des Einflusses ionisierender Strahlung
(2022-10-11)Mesenchymal stem cells (MSCs) exhibit a promising therapeutic potential in the field of cell-based tissue engineering and regenerative medicine due to their immunomodulatory properties and differentiation capacity. In ...