Background: Patients with an intensive care unit-acquired weakness (ICU-AW) often present clinically with severe paresis of the limb and trunk muscles while facial muscles appear less affected. To investigate whether the ...

Myelin sheaths built by oligodendrocytes in the central nervous system (CNS) are not only important insulators that enable the fast saltatory propagation of action potentials but also fulfill metabolic support functions ...

The dementia group of diseases share some features such as the degeneration of neurons, which leads to progressive and irreversible loss of cognitive functions. Since almost 10 years, dementia syndromes were declared a ...

According to the influential amyloid cascade hypothesis cerebral accumulation of Aβ is the key event in the pathogenesis of Alzheimer´s disease. Aβ deposits occur as soluble forms, as well as insoluble forms. It is assumed ...

Small-Fiber-Neuropathy (SFN) is a disease of the thinly myelinated A-delta and unmyelinated C-fibers. This results in a reduction of the intraepidermal nerve fiber density. Affected patients predominantly report acral pain ...

Aim of the study was to investigate the effects of repeated anodal tDCS on the human motor-cortex. tDCS is a non-invasive brain stimulation techniques, which is able to produce neuroplasticity changes in humans. So far ...

This work focuses on the different neuroprotective properties of the co-chaperone BAG1 (Bcl-2-associated athanogene-1) in various models of Parkinson's disease. In a SH-SY5Y cell culture ...

Psoriasis is a chronic recurrent inflammatory disease of the skin and joints, often associated with significant morbidity. In spite of its clinical importance, the pathogenesis of psoriasis is not fully understood. Recently, ...

The incurable systemic sclerosis results from permanent myofibroblast activity and the associated overproduction of ECM proteins. The central question of this work was whether inhibition of individual NF-κB subunits could ...