Browsing Human- und Zahnmedizin by Title
Now showing items 1993-2012 of 3410
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Modulation der synaptischen Plastizität im Rett-Syndrom durch Antioxidantien-Fütterung
(2021-10-05)Rett syndrome is a severe neurodevelopmental disorder that almost exclusively affects females. Upon an apparently normal development during the first 6 – 18 months of life, developmental stagnation and especially neurological ... -
Modulation der T-Zell-Infiltration und der Aktivierung von Makrophagen/Mikroglia bei der EAE durch zellspezifische Deletion des Arylkohlenwasserstoffrezeptors (AhR)
(2024-08-26)To better understand the pathomechanisms underlying multiple sclerosis, the role of the Ah receptor (AhR) in immune cell recruitment to the CNS was investigated using the murine experimental autoimmune encephalomyelitis ... -
Modulation der zytosolischen Redox-Balance durch aktivitätsinduzierte Ca2+-Signale in hippokampalen Neuronen der Maus
(2025-06-24)Intracellular Ca2+ signals are essential for the modulation of cellular activity and excitability but also represent critical components of cellular dysfunction and damage in various neurological disorders. The aim of this ... -
Modulation hippokampaler neuronaler Apoptose und Neurogenese durch Fas apoptotic inhibitory molecule 2 (Faim2) im Rahmen der experimentellen Streptokokkenmeningitis
(2014-01-06)Fas apoptotic inhibitory molecule 2 (Faim2) is a neuron-specific membrane protein and a member of the evolutionary conserved lifeguard (LFG) apoptosis regulatory gene family, acting as a proximal inhibitor of the Fas-FasL ... -
Molecular assembly of auditory ribbon synapses in mice
(2025-01-17)Auditory ribbon synapses are specialized structures in the inner hair cells (IHCs) that enable rapid neurotransmitter release, making them essential for precise signal transmission in the auditory system. However, insights ... -
Molecular Basis of Mitochondrial Diseases Exemplified by Mutation of the Translation Factor Cox14
(2023-11-07)Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. More and more evidence shows that mitochondrial ... -
Molecular mechanisms of insulin resistance in glucagon-producing alpha cells
(2006-11-22)Type II diabetes mellitus is a chronic disease, affecting more than 150 million people worldwide. Type II diabetes mellitus is characterized by insulin resistance of peripheral tissues ... -
Molecular mechanisms of the TGFβ1 Arg25Pro polymorphism related to acute radiotherapy-induced toxicity
(2015-03-25)In radiochemotherapy administered for rectal cancer, all patients harboring the Pro25 allele in the signal peptide of TGFβ1 experienced a higher grade of acute treatment toxicity. Pro25 features an allelic frequency of ... -
Molekular-genetische Prädiktoren der Toxizität einer neo-adjuvanten Radiochemotherapie am Beispiel des Rektumkarzinoms
(2019-02-22)In Germany, around 20,000 people per year are diagnosed with rectal cancer. Neoadjuvant radiochemotherapy (N-RCT) has been established for routine treatment of cancers located in the lower and middle third of the rectum. ... -
Molekular-zytogenetisches Monitoring aus dem peripheren Blut bei Hoch-Risiko-MDS Patienten unter Therapie mit Azacitidin
(2023-11-03)In myelodysplastic syndromes (MDS) pathogenesis, diagnosis, prognosis and also therapy are significantly influenced by chromosomal aberrations. In this retrospective analysis of 76 high-risk MDS patients treated with ... -
Molekulare Analyse eines Homöobox-Gen-Promotors in der Gehirnanlage von Wirbeltierembryonen
(2002-12-09)The ANF homeobox genes belong to the earliest group of genes expressed in the vertebrate anterior central nervous system. Targeted disruption of the murine ortholog Hesx1 reveals morphological ... -
Molekulare Charakterisierung des COPS5-Gens und seines Genproduktes als Kandidat für die Spastische Spinalparalyse
(2011-02-24)Hereditary spastic paraplegias (HSP) are a clinically and genetically heterogeneous group of neurodegenerative disorders. There are autosomal dominant (AD), autosomal recessive (AR), or ... -
Molekulare Charakterisierung des murinen 66.3-kDa-Proteins
(2008-05-19)The mouse 66.3-kDa protein was identified as one of several putative novel lysosomal matrix proteins by analyzing mannose 6-phosphate receptors binding proteins (Kollmann K, Mutenda KE, Balleininger M, Eckermann E, von ... -
Molekulare Charakterisierung von kolorektalen Lebermetastasen mit unterschiedlichen histopathologischen Wachstumsmustern
(2024-12-12)Colorectal cancer liver metastases express different histopathological growth patterns. The three common ones are the replacement, the desmoplastic, and the pushing histopathological growth patterns. Whereas the both latter ... -
Molekulare Charakterisierung von ZFYVE27 und Identifizierung von Deletionen in SPG4
(2010-04-29)Hereditary spastic paraplegia (HSP) are a clinical and genetically heterogeneous group of neurodegenerativ illnesses, which are characterized by progrediente spastic paraparese and hyperreflexy ... -
Molekulare Determinanten zur sequenzspezifischen DNA-Bindung des Transkriptionsfaktors STAT1
(2018-01-09)STAT proteins (signal transducers and activators of transcription) play an essential part in one of the oldest and highly conserved signal transduction pathways. The JAK-STAT pathway transmits signals from many cytokines ... -
Molekulare Marker der frühen anterior-posterioren Achsenbildung im Kaninchen
(2021-06-16)During the early development of vertebrates, specific, morphological domains as signs of the developing anterior-posterior axis formation appear and define the body axes as the crucial step for Gastrulation and further ... -
Molekulare Mechanismen der antiproliferativen und antifibrotischen Wirkung von Mycophenolsäure in vitro
(2018-01-02)The aim of this study was to elucidate functional and molecular effects of mycophenolic acid (MPA) on non-lymphatic, kidney epithelial cells treated with transforming growth factor (TGF). MPA effects were studied using HK2 ... -
Molekulare Mechanismen des radiosensibilisierenden Effektes von Chloroquin beim Glioblastoma multiforme
(2013-10-16)Introduction: Glioblastoma multiforme (GBM) is the most aggressive brain malignancy. The clinical outcome remains disappointing, mainly due to inevitable GBM recurrence after postoperative radiation and chemotherapy. An ... -
Molekulare und elektrophysiologische Untersuchung der Exozytose in der Maus-Cochlea
(2023-12-20)The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, I studied the role of Rab3 ...