Browsing Human- und Zahnmedizin by Title
Now showing items 2111-2130 of 3230
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Persistierende DNA-Schäden (Mikronuklei) und Spättoxizität nach multimodaler Radiochemotherapie bei Patienten mit lokal fortgeschrittenem Rektumkarzinom
(2013-08-05)In this thesis, 48 patients who underwent multimodality treatment for locally advanced rectal cancer in the context of the CAO/ARO/AIO-04-trial were investigated. Patients received neoadjuvant chemoradiotherapy (CRT) either ... -
Persistierender postoperativer Schmerz nach Hüftgelenksersatz - Prävalenz, Risikofaktoren und Einfluss auf Alltagsfunktionen und Lebensqualität.
(2019-06-24)This prospective observational study investigates the prevalence of persistent postoperative pain (PPOP) after endoprosthetic hip replacement as well as the presence of related risk factors. Furthermore, it was investigated ... -
Personalisierte Medizin beim medikamentösen Verschluss des persistierenden Ductus arteriosus - ein Vergleich zwischen konventioneller Ibuprofen-Therapie und einem patientenadaptierten/individualisierten Indometacin-Therapieschema
(2023-02-09)Background To evaluate using a conventional ibuprofen versus a patient adapted protocol of indomethacin for closure of patent ductus arteriosus. Methods In two consecutive periods, all infants treated for clinically ... -
Persönlichkeit und Inkongruenzerleben als Determinanten des Effekts eines 6-wöchigen hochfrequenten, standardisierten Sportprogramms (SIWAS-Studie)
(2025-01-17)The therapeutic effect of exercise on mental illness has already been shown many times and for patients with various mental illnesses, especially depression (Knapen et al. 2014, Dauwan et al. 2015). However, little research ... -
Persönlichkeit, neurohumorale Aktivierung, Bindungsstile und subjektives Befinden bei Patienten mit kardiovaskulären Risikofaktoren oder Herzinsuffizienz aus der Diast-CHF-Studie
(2019-09-11)Background: Chronic heart failure (HF) is one of the most important health problems in the industrialized world. Several hormonal systems are involved in the pathophysiology of HF. The activation of GDF-15 leads to a ... -
Perspektiven und Bedürfnisse von Patientinnen und Patienten mit fortgeschrittener chronisch obstruktiver Lungenerkrankung (COPD) am Lebensende
(2021-11-16)The aim of the study was to determine the individual perspectives and needs of patients with advanced COPD, a progressive disease without any chance of recovery, at the end of their life. In order to achieve this, a ... -
PFKFB3-Inhibition während einer Radiochemotherapie des Rektumkarzinoms – Überprüfung in einem patient-derived xenograft In-vivo-Modell
(2024-01-29)Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide and the second leading cause of cancer death. Approximately 30% of colorectal carcinomas are localized in the rectum. Neoadjuvant radiotherapy ... -
Die pH-Abhängigkeit des NaDC3-Transporters
(2017-11-27)The sodium-dependent dicarboxylate transporter 3 (NaDC3) is located close to organic anion transporters (OAT) in the basolateral membrane of renal proximal tubule cells. The transport-activity of OAT1 (p-aminohippurate) ... -
Eine Phantomstudie zur Strahlenexposition des Untersuchers bei Rotationsaquisitionen mit einer Flachdetektor-Angiographie-Anlage
(2014-07-21)In addition to the conventional digital subtraction angiography (DSA), rotation angiographies and DYNA-CTs have been implemented particularly since the introduction of angiographic systems using flat-panel detector technology. ... -
Pharmakogenetische Untersuchungen beim Hausarzt aus Sicht von Patienten
(2008-11-24)Background: Pharmacogenetic testing could, in the future, help gauge the effects, adverse side effects and necessary dosage of a medication prior to consumption. The aim of this study was ... -
Die Pharmakokinetic von Meropenem bei Patienten mit schweren Infektionen
(2010-08-04)Meropenem is a carbapenem antibiotic with a broad antibacterial spectrum, good tolerability and high penetration into infected tissues. Due to its excellent pharmacokinetic and pharmacodynamic ... -
Pharmakokinetik von Doxorubicin: Populationsvariabilität und Einfluss von genetischen Polymorphismen in Membran-Trasportproteinen
(2007-08-02)In this thesis, the impact of genetic polymorphisms of the membrane transporters MDR1, MRP1, MRP2, MRP3 and BCRP on the pharmacokinetics and side effects of doxorubicin of 94 non-pretreated ... -
Pharmakologische Behandlung von stationären Patienten mit einer emotional instabilen Persönlichkeitsstörung
(2016-03-08)Disease-related deficits in the everyday social interaction are responsible for socially inadequate integration of patients with borderline personality disorder (BPS). The supply resources due to the extensive psychosocial ... -
Pharmakologische Charakterisierung der purinergen Rezeptoren der Stützellen der olfaktorischen Mukosa des larvalen Xenopus laevis
(2011-04-06)Extracellular purines and pyrimidines are important signaling molecules acting via purinergic receptors. In the present work ATP-induced responses in sustentacular supporting cells of ... -
Pharmakologische Inhibition von Rho-Kinase im Mausmodell der Amyotrophen Lateralsklerose
(2015-06-12)Since the development of Riluzol no substance, which had been successfully tested in a preclinical setting before, has been able to be successful as a disease modifying drug in human ALS although there has been enormous ... -
Pharmakologische rho-Kinasen-Inhibition im H4-Zelllinien-Modell des Morbus Parkinson
(2024-04-26)Parkinson's disease (PD) is the most common neurodegenerative movement disorder, unfortunately there are no curative therapeutic approaches to date. Rho-associated protein kinase (ROCK) has been described as a novel ... -
Phäno- und genotypische Charakterisierung konsekutiver Isolate eines Patienten mit rezidivierenden Clostridium difficile-Infektionen
(2019-03-06)Thirteen C. difficile isolates deriving from recurrent infections of a single patient were isolated during a fifteen-month ongoing course of disease and analyzed regarding their morphology, phenotype and genotype. The ... -
Phänotyp-Analyse und Genotyp-Phänotyp-Assoziationen bei 83 mit FOXG1-Syndrom
(2019-05-13)Purpose: The aim of this study was to increase the knowlegde about the clinical spectrum and to evaluate genotyp-phenotyp associations in FOXG1 syndrome due to FOXG1 variants. Methods: We recruited 30 new and 53 reported ... -
Phänotypische Charakterisierung humaner Monozyten von Blutspendern mit chronischer Toxoplasmose und nicht-infizierten Kontrollen
(2020-11-13)The globally distributed parasite Toxoplasma gondii (T. gondii) is an obligatory intracellular protozoan and the infectious agent of toxoplasmosis in humans and animals. Humans become regularly infected by ingestion of ... -
Phänotypische und funktionelle Charakterisierung der kutanen Immunantwort bei Kontakt mit Natriumlaurylsulfat
(2025-02-14)Sodium lauryl sulfate (SLS) is regularly used as a so-called irritancy control in patch testing in the allergological diagnosis of contact allergies and we encounter it in everyday life, for example in soaps, cleaning ...