Browsing Human- und Zahnmedizin by Title
Now showing items 2881-2900 of 3380
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Untersuchung der systemischen und parakrinen Wirkungen von Leptin auf die Neointimabildung nach experimenteller Gefäßverletzung im Mausmodell
(2016-04-04)Obesity is a very good known risk factor of atherothrombotic complications of the heart and the vessel system. Additionally growing bodyweight and elevated mass of the perivascular adipose tissue (PVAT) and visceral adipose ... -
Untersuchung der therapeutischen Wirkmechanismen von Kurkumin in diffus intrinsischen Ponsgliomen in Abhängigkeit vom Mutationsstatus im H3F3A-Histongen (H3.3K27M-Mutation)
(2022-10-17)Diffuse intrinsic pontine glioma (DIPG) are pediatric high grade glioma localized in the brainstem and associated with a fatal prognosis. 85% of all DIPG carry a H3K27M mutation, which leads to epigenetic dysregulation ... -
Untersuchung der Transportvorgänge des Prolyl-Hydroxylase-Hemmers ICA an den Transportern OAT1, OAT2, OAT3 und OAT4 von proximalen Nierentubuluszellen
(2017-10-27)This thesis discusses the interactions between ICA and the organic anion transporters OAT1, OAT2, OAT3 and OAT4. ICA is a substance which can inhibit the prolyl hydroxylase domain. This leads to an upregulation of hypoxia ... -
UNtersuchung der unterschiedlichen Funktion des Neuregulin-1 im Hinblick auf die Myelinisierung des peripheren und zentralen Nervensystems
(2012-05-14)Understanding the control of myelin formation by oligodendrocytes is essential for treating demyelinating diseases. Neuregulin-1 (NRG1) type III, an EGF-like growth factor, is essential for myelination in the PNS. It is ... -
Untersuchung der Verteilungs- und Expressionsmuster von Cannabinoid 1-Rezeptor-positiven Interneuronen im Neokortex der Maus
(2025-02-20)Inhibitory interneurons regulate the network activity of cortical neuronal ensembles through the release of the neurotransmitter γ-aminobutyric acid (GABA). Interneurons (IN) exhibit significant heterogeneity concerning ... -
Untersuchung der Wirkung des antiaggregativen Compounds anle138b auf Löslichkeit und Toxizität von mutierter SOD1
(2017-11-02)Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the upper and lower motoneuron with flabby and spastic paralysis leading to death within three to five years because of respiratory insufficiency. ... -
Untersuchung der Wirkung eines Impfstoffes gegen Harnwegsinfektionen auf das angeborene Immunsystem
(2024-09-10)The treatment of urinary tract infections is usually accompanied by a high consumption of antibiotics, which are used for the treatment of acute urinary tract infections, but also in low doses for long-term prophylaxis ... -
Untersuchung der Wirkung von HDAC-Inhibitoren auf das Amyloid-Vorläufer-Protein (APP) in Tumorzellen
(2013-09-18)The ß-amyloid precursor protein (APP) is an integral membrane protein, which is expressed in neuronal and non-neuronal human cells. In addition to its well-known relevance in the pathogenesis of Alzheimer’s disease, APP ... -
Untersuchung des CFL-Phänotyps ("congenital fused labia" ) in dem Neuweltaffen Common Marmoset (Callithrix jacchus) unter demographischen, physiologischen und zytogenetischen Gesichtspunkten
(2010-08-05)The theme of this submitted doctoral dissertation is a multiple aspect investigation of the phenotype closed vulva (congenital-fused-labia (CFL) which commonly occurs in young and adult ... -
Untersuchung des Effekts einer Überexpression von Cathepsin B in Zielzellen zytotoxischer Zellen
(2012-06-12)Cytotoxic T cells lyse malignant tumor cells by releasing perforin and granzymes from preformed cytotoxic granules. Within the cytotoxic response the target cells and the killer cells are exposed to cell death mediators. ... -
Untersuchung des Einflusses der LTD-artigen motorkortikalen Plastizität auf die interhemisphärische Konnektivität bei Patienten mit einer Schizophrenie
(2018-03-20)Post-mortem and in vivo studies provide evidence for a link between reduced plasticity and dysconnectivity in schizophrenia patients. It has been suggested that the association between plasticity and connectivity contributes ... -
Untersuchung des Einflusses von Leptin auf die Thrombozytenfunktion sowie Analyse der Leptin-vermittelten Signalkaskade in Thrombozyten
(2015-03-04)Obesity is an increasing problem in industrial countries. It is an independent risk factor for the development of different diseases like stroke, pulmonary embolism, and myocardial infarction. Cardiovascular diseases are ... -
Untersuchung des Sekretoms chondrogener Progenitorzellen mittels metabolischer Markierung und quantitativer Massenspektrometrie
(2012-06-01)The field of "tissue engineering" in the context of osteoarthritis therapy research is very promising. First evidence could show that chondrogenic progenitor cells may be used in future to regenerate cartilage tissue in ... -
Untersuchung des Stellenwerts von transurethraler und suprapubischer Harnableitung in der Therapie von Prostatitis, Epididymitis und Pyelonephritis
(2020-01-21)Complicated urinary tract infections (UTI) such as prostatitis and epididymitis in men or pyelonephritis in women are a common reason for urological hospital ad-missions. For the patient, this means not only physical ... -
Untersuchung des Stuhlverhaltens von Neugeborenen in Abhängigkeit von extrinsischen Faktoren (Kohorten Studie)
(2025-02-03)Delayed meconium passage in preterm infants is common in very low birth weight infants, and there is evidence in the literature of a high risk of gastrointestinal complications, particularly in preterm infants of low ... -
Untersuchung des unterschiedlichen Therapieansprechens FGFR1-amplifizierter Lungenkrebszellen
(2024-10-28)Lung cancer still continues to be the leading cause of cancer-related death worldwide. While there already exist molecular targeted therapies for the treatment of pulmonary adenocarcinomas molecular targets for squamous ... -
Untersuchung des Zusammenhangs zwischen SUMO2/3-Konjugaten und Zellstress in einem In-vitro-Modell
(2020-12-16)Small ubiquitin-like modifiers (SUMO) are small proteins which connect to other proteins through a pathway similar to that of ubiquitin. So SUMO-conjugation is part of the posttranslational modifications. The three main ... -
Untersuchung einer Calcineurin-bindungsdefizienten FKBP12.6-Mutante in Kardiomyozyten
(2010-07-26)The ryanodin receptor, the largest known ion channel of the heart muscle cell is known as a multi protein complex. It´s activity is regulated by proteins like kinases and phosphateses. ... -
Untersuchung eines möglichen protektiven Effekts von ß-Ecdyson auf die Haut und die Serumlipide bei Sexualhormonmangel
(2013-12-20)20-hydroxyecdysone (Ecd) has numerous favorable effects on a variety of organs, including the skin, where it improves wound healing, and serum lipids. It is devoid of estrogenic and androgenic effects. Therefore, application ... -
Untersuchung genetischer und geschlechtlicher Einflüsse in der Alzheimerpathologie anhand des Maustiermodells 5XFAD
(2010-10-27)The Alzheimer´s Disease is the most frequent dementia. In Germany are approximately 900.000 individuals affected. Although there are great efforts to investigate the pathogenesis, there is ...