Browsing Human- und Zahnmedizin by Title
Now showing items 294-313 of 3377
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Die Bedeutung der Hedgehog- Signalkaskade in der Tumorgenese von spinalen und kraniellen Chordomen
(2017-07-13)Chordoma is a rare type of cancer that occurs in the bones of the skull base and spine, arising from remnants of embryonic notochord. Although they are slow growing, chordomas are highly recurrent, locally invasive and ... -
Die Bedeutung der Kalzium/Calmodulin-abhängigen Proteinkinase II für den gestörten Kalziumstoffwechsel der isolierten Rattenherzmuskelzelle unter Doxorubicinbehandlung
(2013-07-08)Doxorubicin (DOX), a member of the anthracycline family, is one of the oldest and most commonly used chemotherapeutic agents. Despite its therapeutic benefits, its cardiotoxic potential, resulting in severe cardiac damage, ... -
Bedeutung der Leptinrezeptor-vermittelten Aktivierung des Transkriptionsfaktors STAT3 für die Effekte des Adipokins Leptin auf Blutplättchen
(2014-10-08)Other studies have shown that the leptin receptor is also expressed on platelets (Nakata et al. 1999) and that leptin dose-dependent promotes platelet aggregation. According to these findings there have been many investigations ... -
Bedeutung der mikrobiellen Transmission im SIV-Rhesusaffen-Tiermodell für die HIV/AIDS-Pathogenese
(2011-02-18)Chronic immune activation is a major aspect of HIV infection and AIDS pathogenesis. Recent data suggests that immune activation is mainly caused by translocation of microbial products through ... -
Die Bedeutung der Modulation der Exosomensekretion durch den ABC-Transporter A3 für die intrinsische Zytostatikaresistenz von aggressiven B-Zell-Lymphomen
(2020-05-28)During the therapy of malignant B-cell lymphomas the humoral immunochemotherapy with anthracycline-based chemotherapy and with monoclonal antibodies against the differencing antigen CD20 is the basis of the primary therapy. ... -
Die Bedeutung der natriuretischen Peptide für die Diagnose einer diastolischen oder systolischen Funktionsstörung
(2011-09-14)The diagnostic value of natriuretic peptides in asymptomatic patients at risk for diastolic or systolic HF is contended. The prevalence of preclinical LV dysfunction in an at-risk cohort ... -
Die Bedeutung der Proteinkinase A und der Ca2+/Calmodulin abhängigen Proteinkinase II für das Sarkoplasmatische Retikulum Kalziumleck in der humanen Hypertrophie und Herzinsuffizienz
(2022-09-22)Sarcoplasmic reticulum (SR) Ca2+ leak through ryanodine receptor type 2 (RyR2) hyperphosphorylation is a key pathomechanism in human heart failure (HF). The resulting increased spontaneous diastolic calcium release promotes ... -
Die Bedeutung der Thymidinphosphorylase bei Patienten mit lokal fortgeschrittenem Rektumkarzinom (UICC-Stadium-II/-III) im Kontext einer 5-FU basierten multimodalen Therapie
(2014-06-19)Thymidine phosphorylase (TP) is an enzyme, which is involved in the physiological metabolism of each cell. There it acts as an angiogenic factor, but further catalyzes at least three known reactions, which are related to ... -
Die Bedeutung der transösophagealen Echokardiographie beim Schlaganfall - Ergebnisse einer großen monozentrischen Querschnittsstudie
(2021-02-18)Strokes are one of the leading causes of death worldwide. Despite intensified diagnostics, the majority of strokes must be classified as cryptogenic. In this context the role of a PFO with or without ASA seems unclear and ... -
Die Bedeutung der δ-Isoform der Kalzium-Calmodulin-abhängigen Proteinkinase II (CaMKII) für die Azidose bei isolierten Kardiomyozyten
(2013-10-23)Objective: CaMKII-dependent Thr-17 phosphorylation of PLB leading to higher SERCA activity has been suggested to maintain or even partially recover fractional shortening (FS) and intracellular Ca transient amplitude (ΔF/F0) ... -
Bedeutung des Cytochrom-P450-2C9- und -3A5-Genpolymorphismus für Pharmakokinetik, Wirkungen und Nebenwirkungen von Delta-9-Tetrahydrocannabinol bei gesunden Probanden und Probandinnen
(2009-06-25)Context: Concerning the consumption of illegal drugs, cannabis (main ingredient Delta-9-THC) has been the most common substance for 30 years in Germany and Europe. Nowadays THC is a subject ... -
Bedeutung des cytosolischen Teils des großen Hüllproteins für die Umhüllung des Hepatitis B Virus Nukleokapsids
(2002-12-19)The final step in hepatitis b virus formation is the envelopment of the pre-assembled nucleocapsid at the membrane of the endoplasmatic reticulum which contains the viral surface ... -
Bedeutung des G-Protein-gekoppelten Estrogen-Rezeptors 1 (GPER1) für die Progression des Vulvakarzinoms
(2024-06-20)The vulvar carcinoma is a gynecological tumor that primarily affects older women. It mostly comprises squamous cell carcinomas. The standard treatment typically involves a triple therapy of radiation, chemotherapy and ... -
Die Bedeutung des Immunoproteasoms in der Behandlung epithelialer Thymustumoren
(2024-10-28)Thymic epithelial tumors are rare neoplastic diseases of the thymus and are divided into thymomas and thymic carcinomas based on their histopathological characteristics. Surgical tumor resection is the first choice of ... -
Die Bedeutung des Kollagenrezeptors α2β1- Integrin bei der Pathogenese und Prävention der Nierenfibrose in hereditären Typ IV- Kollagen- Erkrankungen
(2011-04-11)Collagen IV as a major component of basal laminae has an important role not only in defining the structure of tissues but also in transmitting signals that influence normal cell function ... -
Die Bedeutung des Kollagens für die Regeneration der Rotatorenmanschette: Histologische und immunhistologische Untersuchung der Verteilung der Kollagene Typ I, Typ II und Typ III nach single- und double-row-Naht-Anker-Rekonstruktion
(2011-02-17)Introduction: In recent biomechanical studies, the double-row suture anchor reconstruction for surgical treatment of rotator cuff tears showed better biomechanical results when compared to ... -
Bedeutung des löslichen CD14-Rezeptors in Plasma und Urin als immunologischer Parameter nach Nierentransplantation und sein Verhältnis zu den löslichen Rezeptoren IL2R, CD4 und CD8
(2011-05-02)The soluble CD14 (sCD14) is increased in plasma during an immunological activation. For patients following kidney transplantation the avoidance or early detection and treatment of complications ... -
Die Bedeutung des p75-Neurotrophinrezeptors während der De- und Remyelinisierung im Cuprizon- Modell der Multiplen Sklerose
(2013-05-30)Multiple sclerosis (MS), the most frequent central nervous system (CNS) autoimmune disease is characterized by multiple focal demyelinated lesions. Partial remyelination of these lesions is frequently observed and considered ... -
Bedeutung des primären Infektfokus für die Morbidität und Mortalität bei Patienten mit Sepsis
(2017-10-23)a comparison of the outcome of patients with sepsis in view of infection site, especially nosocomial pneumonia, intraabdominal infection and primary bacteremia -
Die Bedeutung des Pyroglutamat-Abeta-Oligomer-Blutplasmaspiegels und des Apolipoprotein-E-Genotyps bei der Alzheimer-Krankheit
(2012-04-04)Alzheimer's Disease is a severe neurodegenerative disorder and the most common of the worldwide 24 million cases. The characteristics are, besides the clinical manifestation, neuropathological hallmarks like deposits ...