Browsing Human- und Zahnmedizin by Issue Date
Now showing items 21-40 of 3175
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Adhäsionsverhalten von Multispezies-Biofilmen aus Aggregatibacter actinomycetemcomitans, Staphylococcus epidermidis und Streptococcus sanguinis auf Titanoberflächen in vitro
(2025-02-25)Objective: Biofilm-associated peri-implant diseases are a major cause of the loss of osseointegrated dental implants. The accumulation of oral biofilms is primarily influenced by the surface topography of biomaterials ... -
Wirkung des standardisierten japanischen Kampo-Arzneipflanzenpräparates Juzentaihoto auf das Tumormikroenvironment des Pankreaskarzinoms – ein Vergleich mit Gemcitabin
(2025-02-24)Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive gastrointestinal malignancies, characterized by poor prognosis and limited therapeutic success. Despite surgical resection being the sole curative approach, ... -
Übereinstimmung anamnestischer Informationen aus einer App-basierten Anamnese im Vergleich zu einem persönlichen Gespräch in der Primärversorgung
(2025-02-24)Background: With the help of digital tools patients' medical histories can be collected quickly and transferred into their electronic medical records. This information can facilitate treatment planning, reduce documentation ... -
Analyse des Einflusses unterschiedlicher Sprunggelenksorthesenkonfigurationen auf die muskuläre Aktivität zur Fortbewegung
(2025-02-20)Ankle foot orthoses (AFOs) can help to support the human gait. In this dissertation, the effect of different configurations of an AFO with different spring stiffnesses (5, 10, 15, 20 and 25 kN/m) on the muscular activity ... -
Die Wirkung von Alizarin, Calcein und dem Oberflächenmarker PKH2 auf das Proliferationsverhalten von Rothirsch-Geweihzellen
(2025-02-20)In an experimental study, the effect of fluorescent dyes on the proliferation behavior of red deer antler cells was examined using cell cultures. The investigation was conducted in two experimental setups. In the first ... -
Der Einfluss des Stammzellfaktors KLF4 auf die TGFβ-Aktivität im CHD1-depletierten Prostatakarzinom
(2025-02-20)In the course of prostate cancer, castration resistance often develops, which is associated with a poorer prognosis and increased mortality rates. A mutation of the chromatin remodeler CHD1 plays a crucial role in this ... -
Culinary Medicine – A new teaching approach to improve medical students’ counselling skills for nutrition-associated diseases. Review and exploratory pilot study at Göttingen medical school
(2025-02-20)Global health is increasingly impaired by the burden of Non-Communicable Diseases. NCDs like cardiovascular and metabolic diseases or cancer are often associated to peoples’ nutrition. Either the disease’s pathology is ... -
Genetic drivers of metastatic colorectal cancer liver colonization
(2025-02-20)Metastasis is the leading cause of death from colorectal cancer (CRC), yet the genes and pathways driving CRC metastatic progression are poorly defined. Among the steps in the metastatic cascade, liver colonization is a ... -
Untersuchung der Verteilungs- und Expressionsmuster von Cannabinoid 1-Rezeptor-positiven Interneuronen im Neokortex der Maus
(2025-02-20)Inhibitory interneurons regulate the network activity of cortical neuronal ensembles through the release of the neurotransmitter γ-aminobutyric acid (GABA). Interneurons (IN) exhibit significant heterogeneity concerning ... -
Stratifizierung des Re-Identifikationsrisikos medizinischer Daten
(2025-02-17)As a result of advancing digitalization and technical development, an ever-increasing amount of medical data is being generated in everyday clinical practice and in the healthcare sector in general (Rüping et al. 2019). A ... -
Mechanismen der Tumorsuppression und Resistenzüberwindung einer therapeutischen GSK-3β- Inhibition im Pankreaskarzinom
(2025-02-17)Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of human cancer with a five-year survival of only 11%. Recent studies have shown that PDAC results from a successive accumulation of different ... -
Biomechanische Analyse der Auswirkung einer Fixierung des Iliosakralgelenks auf relevante Bewegungen
(2025-02-14)Pelvic ring fractures place high demands on treatment due to the severity of the injury. Type B and type C injuries, which are often caused by high-impact trauma and lead to instability of the pelvic ring, are particularly ... -
Neodym:YAG-Lasertherapie mukoider Dorsalzysten: Klinische Wirksamkeit und Effekte in einem 3D-Gewebemodell
(2025-02-14)This study evaluates Nd:YAG-laser treatment as a novel therapeutic option for mucoid dorsal cysts, for which no standard procedure currently exists. In the first part, the clinical efficacy and potential of this new treatment ... -
Phänotypische und funktionelle Charakterisierung der kutanen Immunantwort bei Kontakt mit Natriumlaurylsulfat
(2025-02-14)Sodium lauryl sulfate (SLS) is regularly used as a so-called irritancy control in patch testing in the allergological diagnosis of contact allergies and we encounter it in everyday life, for example in soaps, cleaning ... -
Visualisierung neutrophiler Granulozyten und NETs (Neutrophil Extracellular Traps) mit Expansionsmikroskopie
(2025-02-14)Neutrophil granulocytes are short-lived immune cells which play a significant role in the innate immune system. They are the most abundant immune cell type in the blood as well as part of the first line of defence of the ... -
Prospektive Untersuchung von prognostischen Markern des Nierenschadens beim kardiorenalen Syndrom: Erfassung der Auswirkung von SGLT2 Inhibitoren auf Parameter der renalen Kongestion
(2025-02-14)The cardiorenal syndrome, defined as the concurrent occurrence of kidney and heart disease, is a common phenomenon in clinical practice. Renal venous congestion plays a significant role in the pathophysiology and prognosis ... -
AMPK inhibitor-based combination therapies in pancreatic ductal adenocarcinoma
(2025-02-14)Regarding the dismal prognosis of pancreatic ductal adenocarcinoma, this thesis aimed to identify a new therapeutic option by inhibiting the adenosine monophosphate-activated protein kinase (AMPK). Since cancer cells grow ... -
Eine Untersuchung von Biomarker-Profilen bei Patienten im Spektrum zwischen Alzheimer-Demenz und vaskulärer Demenz
(2025-02-10)Developing dementia significantly alters the everyday life and quality of life of the affected patients. In the end stage of dementia, the diseased often experience complete helplessness and need for care. In contrast to ... -
Bypass von mRNA-Qualitätskontrolle generiert aberrante EYA1-Isoform in tumorassoziierten Fibroblasten des Pankreas-CA
(2025-02-10)EYA1 plays a key role in the embryonic development of various organs. Further, it has a profibrotic effect, thus influencing the pathogenesis of various diseases and malignancies. Its tyrosine phosphatase activity and ... -
Retrospektive Analyse der Clostridioides difficile-Infektionen vom Jahr 2016 bis zum ersten Tertial des Jahres 2017 im geriatrischen Zentrum des Evangelischen Krankenhauses Göttingen-Weende
(2025-02-10)Background: Clostridioides (C.) difficile is a common pathogen of nosocomial infections. Elderly patients who have received antibiotic therapy are particularly affected. The incidence and severity of C. difficile infections ...