Dokumente Human- und Zahnmedizin nach Erscheinungsdatum
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Molekulare und elektrophysiologische Untersuchung der Exozytose in der Maus-Cochlea
(2023-12-20)The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, I studied the role of Rab3 ... -
Inzidenz und prädiktive Faktoren des bilateralen papillären Schilddrüsenkarzinoms
(2023-12-20)Papillary thyroid carcinoma is showing an increasing incidence worldwide, not least due to improved diagnostic options. Papillary microcarcinoma, which is defined as a papillary thyroid carcinoma with a tumor size ≤10 mm, ... -
Untersuchungen zum Serin- und Glycin-Metabolismus und der Phosphoserin-Aminotransferase 1 in der Modellzelllinie P493-6
(2023-12-18)A fundamental trait of cancer cells is the reprogramming of cell metabolism. The complex genesis of aggressive non-Hodgkin lymphoma, such as diffuse large B-cell lymphoma (DLBCL), is accompanied by conversion of cellular ... -
Axonal transport of autophagosomes in models of neurodegeneration in vitro and in vivo
(2023-12-14)Axonal degeneration is a prevalent hallmark of normal aging, trauma, and neurodegenerative CNS diseases. As an early event, it usually occurs prior to neuronal cell death, which has potential therapeutic implications. ... -
Verbesserung der MALDI-TOF-basierten Identifizierung humanpathogener Pilze durch die Erstellung individueller Datenbanken
(2023-12-12)The identification of rare fungal species using MALDI-TOF mass spectrometry is limited by the fact that commercial databases are incomplete or the preparation protocols in routine diagnostics are complex. This dissertation, ... -
Identifikation und Analyse von Interaktionen Erreger-spezifischer Antikörper mit Proteinen des fötalen Gehirns
(2023-12-11)Schizophrenic disorders affect approximately 1% of the global population and are associated with a significant impairment of mental and physical health. To date, similar to many other neuropsychiatric disorders, there is ... -
Gesundheitsbezogene Lebensqualität von Kindern, Jugendlichen und Erwachsenen nach einem Schädel-Hirn-Trauma
(2023-12-07)Traumatic brain injury (TBI) is considered as a major burden on public healthcare systems worldwide. The negative consequences of TBI might affect various aspects of people’s lives, leading to enormous negative effects on ... -
Die Auswirkungen selektiver ERβ-Agonisten auf ERα-positive Brustkrebszellen hängen von den Expressionsniveaus der Östrogenrezeptoren ERα, ERβ und GPER1 und deren Regulation und Interaktion ab
(2023-12-04)Luminal A breast cancers represent the majority of all breast cancers and are more likely to recur and metastasise. In addition, resistance to tamoxifen is a major treatment problem and new therapeutic options are needed. ... -
Individuelle Risikofaktoren für C.-difficile-Infektionen bei stationären geriatrischen Patienten im Ev. Krankenhaus Göttingen-Weende
(2023-12-04)Background: C. difficile infection (CDI) is one of the most common nosocomial diseases worldwide. It is transmitted faecal-orally by spores of toxin-producing Clostridioides difficile (TCD), which are particularly prevalent ... -
Datenbankanalyse zur Myasthenia gravis - Korrelation der Lebensqualität zum klinischen Verlauf
(2023-12-04)As a chronic disease, myasthenia gravis typically results in abnormal muscular fatigue. It accompanies patients for years or even decades and can severely restrict their quality of life and activities of daily living. At ... -
Comfort feeding im palliativen Kontext
(2023-12-04)The aim of this dissertation is to investigate which feeding options (PEG, comfort feeding or change of care objectives) are preferred by general practitioners when caring for patients with advanced dementia and dysphagia. ... -
Die Rolle von ERK1/2 im Prozess des kardialen Remodelings während chronischer Volumenbelastung
(2023-11-23)Chronic heart failure is a disease of great socio-economic importance due to its high prevalence, reduced quality of life, poor prognosis and high healthcare costs. The causes of heart failure include hemodynamic stressors, ... -
Etablierung einer spezifischen Färbung in der röntgenbasierten virtuellen Histologie von Lungenkarzinomen durch den Einsatz goldmarkierter Antikörper
(2023-11-22)Lung cancer is the leading cause for cancer related deaths worldwide. Since the different subtypes can vary considerably in prognosis and available therapeutic options, a precise histopathological diagnosis is essential. ... -
Eine vergleichende Studie der mikrobiellen Hautflora und der bakteriellen Ursachen von Durchfall bei Kindern in städtischen und ländlichen Gemeinden in Indonesien
(2023-11-17)Dieser Arbeit ist die Hypothese vorausgesetzt, dass in Indonesien Enterobacteriaceae einschließlich obligater Krankheitserreger wie Salmonellen, Shigellen und Yersinien bei Kindern, die auf dem Land leben, häufiger vorkommen ... -
Genetische Ursachen syndromaler und nicht-syndromaler Formen der Lippen-Kiefer-Gaumenspalte und funktionelle Analyse möglicher Kandidatengene
(2023-11-17)Oro- and craniofacial malformations comprise a heterogeneous group of congenital developmental disorders of the face and/or skull. Oro- and craniofacial malformations can present in different forms, and can occur as both, ... -
Prospektive Untersuchung, liquoranalytische Aspekte und Evaluation präanalytischer Bedingungen der CXCL13-Analytik bei Patienten mit akuter Neuroborreliose
(2023-11-17)From July 2014 to August 2019, we examined the clinical characteristics and CSF findings of 72 patients (64 adults, 8 children) with neuroborreliosis as part of a prospective study. According to the modified DGN criteria, ... -
Cytoskeletal assembly in axonal outgrowth and regeneration analyzed using STED microscopy
(2023-11-17)The cytoskeleton is essential for axon outgrowth and regeneration. It must be able to tolerate mechanical force and torsion while also allowing for adaptation and response to trauma or injury, such as axonal lesions. Recent ... -
Einfluss des Optifast-52-Programms auf den Leberfibrosegrad von Patienten mit Adipositas
(2023-11-13)Non-alcoholic fatty liver disease is the most common liver disease in the industrialized world, which can progress to non-alcoholic steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. In the context of ... -
Verbessert eine COVID-19-Impfung die soziale Teilhabe immunsupprimierter Personen?
(2023-11-13)Background. The COVID-19 pandemic has affected the organisation of daily life in many ways. In particular, people with a high risk of severe disease progression, such as immunocompromised people, may have experienced major ... -
Das Alter als Verteilungskriterium in der medizinischen humanitären Hilfe
(2023-11-13)Setting priorities in medical humanitarian aid is one of the most pressing issues in this context of particular scarce resources. It is questionable which criteria can be used in case of inescapable allocation decisions ...