Closed Publications
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Das Potenzial spezifischer methylierter DNA im Blut als Biomarker für die Mortalität bei Herzinsuffizienz mit erhaltener Ejektionsfraktion
(2025-05-07)Chronic heart failure is a leading health risk worldwide for the increasingly ageing population. Patients with heart failure with preserved ejection fraction (HFpEF) account for around half of all cases. Making a valid ... -
Bacteriorhodopsin-like cation channelrhodopsin based optogenetic tools for the future optical cochlear implant
(2025-05-07)Deafness is a widespread and severe condition. Electrical cochlear implants, which use electrical stimulation of the auditory nerve, enable speech comprehension in those patients suffering from sensorineural hearing loss. ... -
Identification of differentially m6A methylated circRNAs in patient derived RBM20 mutated and control iPS-Cardiomyocytes
(2025-04-30)Approximately 5% of dilated cardiomyopathies are caused by a mutation in the RBM20 gene, which encodes a protein involved in the splicing of cardiac specific titin and formation of cTTNs, the titin specific circRNA. Although ... -
Differentialdiagnostische Abgrenzung des Panayiotopoulos-Syndroms von der Migräne
(2025-04-22)Migraine is among the most common primary headache syndromes in childhood and adolescence. Panayiotopoulos syndrome (PS) (also known as early-onset benign occipital seizure susceptibility syndrome (EBOSS) or self-limited ... -
Gesundheitsbezogene Lebensqualität von Kindern nach Schädel-Hirn-Trauma: Vergleich der Kinder- und Elternperspektive
(2025-04-14)Pediatric Health-Related Quality of Life (HRQoL) as a measure of subjective well-being and functional capacity has gained increasing importance in recent years. However, the HRQoL of children and adolescents following a ... -
Die Wirksamkeit eines 6-wöchigen hochfrequenten, standardisierten Sportprogramms auf die Erkrankungsschwere in drei Gruppen psychiatrischer Störungen
(2025-04-03)Depression, addiction syndromes and schizophrenia are three of the most common severe psychiatric disorders. For all three disorders, there are established treatment regimes and guidelines for diagnosis and treatment. The ... -
Die Rolle von OPN5 als UV-Licht-sensitiver G-Protein gekoppelter Rezeptor in Melanozyten
(2025-04-02)The UV-A component (~380 nm) of sunlight leads to the pigmentation of the skin, which temporarily protects it from sunburn and DNA damage, and over the long term prevents the development of tumors, such as malignant ... -
Sensibilisierung des triple-negativen Mammakarzinoms gegenüber Tamoxifen durch Hemmung des membranständigen Estrogenrezeptors GPER1
(2025-03-14)Breast cancer that is negative for the estrogen receptor α (ER α), the progesterone receptor and the human epidermal growth factor receptor 2 is referred to as triple-negative breast cancer (TNBC). This tumor subtype is ... -
Ethische Herausforderungen der COVID-19-Pandemie im internationalen Vergleich: Erkenntnisse aus 39 Expert*inneninterviews
(2025-03-06)Since spring 2020, the SARS-CoV-2 coronavirus has spread worldwide, causing profound medical, political, economic, cultural, and bioethical challenges in the ensuing pandemic. While the resulting conflicts initially appeared ... -
Untersuchung der Verteilungs- und Expressionsmuster von Cannabinoid 1-Rezeptor-positiven Interneuronen im Neokortex der Maus
(2025-02-20)Inhibitory interneurons regulate the network activity of cortical neuronal ensembles through the release of the neurotransmitter γ-aminobutyric acid (GABA). Interneurons (IN) exhibit significant heterogeneity concerning ... -
AMPK inhibitor-based combination therapies in pancreatic ductal adenocarcinoma
(2025-02-14)Regarding the dismal prognosis of pancreatic ductal adenocarcinoma, this thesis aimed to identify a new therapeutic option by inhibiting the adenosine monophosphate-activated protein kinase (AMPK). Since cancer cells grow ... -
Outcome und Adhärenz moderierende Faktoren einer intensiven Sportintervention in drei psychiatrischen Störungsentitäten: subjektiver Gesundheitszustand, somatoforme Symptomlast, sportliche Vorerfahrung
(2025-02-06)According to the Global Burden of Disease Study 2010, mental illnesses account for 7.4% of the globally lost healthy life years (Whiteford et al. 2015). Identifying and researching effective therapeutic approaches is ... -
Interaktion zwischen ATG2, ATG9 und WIPI4 und ihre Rolle in der Autophagosommembranbildung
(2025-01-21)Autophagy is a cellular recycling mechanism involved in various physiological functions, such as homeostasis, cellular stress response, and nutrient deprivation. A key step in autophagy is the formation of the autophagosome ... -
Die subakuten Effekte des Psilocybin auf Persönlichkeit, Achtsamkeit und die Auflösung des Selbst
(2024-12-10)Psychedelics are a class of drugs that can occasion similar changes in conscious ex- periences mediated via the G-protein coupled Serotonin 2A receptor. These changes vary from slight distortions in perceptions to ... -
Evaluation der Standard Operating Procedure für das Leitsymptom „Abdominelle Schmerzen” in der Klinischen Akut- und Notfallmedizin
(2024-10-11)The leading symptom ‘abdominal pain’ is one of the most common reasons for patient presentation in German emergency departments. It is not only gaining in importance due to its heterogeneity of differential diagnoses and ... -
Rolle des G-Protein-gekoppelten Östrogenrezeptors 1 (GPER1) beim Zervixkarzinom
(2024-03-21)Cervical cancer is the fourth most common cancer in women and after the mamma carcinoma the second most common gynecological carcinoma. The G-Protein-coupled Estrogen Receptor 1 (GPER1) is an important ubiquitous receptor ... -
Die Auswirkungen selektiver ERβ-Agonisten auf ERα-positive Brustkrebszellen hängen von den Expressionsniveaus der Östrogenrezeptoren ERα, ERβ und GPER1 und deren Regulation und Interaktion ab
(2023-12-04)Luminal A breast cancers represent the majority of all breast cancers and are more likely to recur and metastasise. In addition, resistance to tamoxifen is a major treatment problem and new therapeutic options are needed. ... -
Etablierung eines automatisierten Verfahrens zur Quantifizierung von Plasmakonzentrationen direkter oraler Antikoagulantien
(2023-10-12)More than a decade after their first approval, the imageability of direct oral anticoagulants (DOACs) still poses challenges to laboratories worldwide. Even though calibrator- and matrix-dependent chromogenic tests are now ... -
SUMOylierung in Nervenzellen und deren Regulation durch Sauerstoff und Glukose
(2023-04-27)Small ubiquitin-like modifiers (SUMO) are post-translational modifications (PTM) which, similar to Ubiquitin, are conjugated to specific target proteins. The conjugation is based on an energy-dependent enzymatic cascade, ... -
Zusammenhang der Biomarker NT-proBNP und Galectin-3 mit dem psychischen Befinden und der Lebensqualität von Patient*innen mit Herzinsuffizienz und erhaltener Ejektionsfraktion
(2023-04-17)Chronic heart failure is a complex clinical syndrome associated with high mortality, frequent hospitalizations, poor quality of life, and cost-intensive medical care. Based on ejection fraction, the clinical picture is ...