Closed Publications
Now showing items 1-19 of 19
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In-vitro-Untersuchungen zur Wirksamkeit von Liganden nukleärer Rezeptoren zur Behandlung der Multiplen Sulfatase-Defizienz
(2025-12-08)Multiple sulfatase deficiency (MSD) is a rare lysosomal storage disorder. It is caused by pathogenic variants in the SUMF1 gene, which encodes the formylglycine-generating enzyme (FGE). FGE is required for the posttranslational ... -
Etablierung und Charakterisierung von Zervixkarzinomzelllinien mit stabiler Überexpression des G-gekoppelten Östrogenrezeptors (GPER1)
(2025-10-29)Cervical cancer (CC) remains the fourth most common malignancy among women worldwide, despite effective HPV vaccination strategies. CC can be classified into different histological subtypes. The majority of cases are ... -
Auswirkung veränderter Calciumsensitivität von Myofilamenten auf die Anfälligkeit und Aufrechterhaltung von Episoden des Vorhofflimmerns
(2025-10-24)Atrial fibrillation is the most common atrial arrhythmia and shows an age-dependent increase in incidence. In many cases, diagnosis is only made after the occurrence of complications such as stroke or heart failure. Since ... -
Monozentrische Evaluation des intelligenten Assistenzdienstes OPTINOFA in Bezug auf Prozess- und Qualitätsindikatoren der klinischen Notfallversorgung
(2025-10-15)Currently German emergency departments are regularly affected by Overcrowding. A situation, in which the number of patients exceeds the available staff and resources. In this context the effective management of patient ... -
Analyse des Progressionsrisikos der Monoklonalen Gammopathie unklarer Signifikanz zum Multiplen Myelom anhand immunhistochemischer Marker
(2025-09-17)Background: Monoclonal gammopathy of undetermined significance is a precancerous condition of MM with an annual risk of progression of 1-1.5%. The previously established risk stratification model of the Mayo Clinic is ... -
Mode of action of direct KRAS inhibition and development of KRAS inhibitor-based combination therapies
(2025-08-21)As pancreatic ductal adenocarcinoma (PDAC) has still one of the least favourable survival rates among cancers, better treatment is urgently needed. This thesis aimed to make use of a new class of targeted therapies, the ... -
Funktionelles Apoptose-Profiling zur Weiterentwicklung zielgerichteter Therapien für die adulte T-Zell akute lymphatische Leukämie (T-ALL)
(2025-06-23)T-cell acute lymphoblastic leukaemia is a very aggressive haematological neoplasia characterised by malignantly transformed precursor T-lymphocytes. Considering the poor prognosis and limited treatment options for affected ... -
Reevaluation der standardisierten CCT - Kontrollbildgebung bei Kindern nach neurochirurgischer Tumorresektion
(2025-06-19)After surgical interventions in the field of neurosurgery, postoperative cranial imaging using computed tomography (CCT) was used as a standard control procedure. The aim was to detect or rule out any therapeutically ... -
Network Activity of Antibody Targeted and α/ β -Synuclein Transfected Neurons
(2025-06-16)Parkinson’s disease (PD), is characterised pathologically by a loss of dopaminergic neurons in the substantia nigra pars compacta and concomitant aggregation of the pre-synaptic protein α-synuclein (α-syn), mitochondrial ... -
Identification of differentially m6A methylated circRNAs in patient derived RBM20 mutated and control iPS-Cardiomyocytes
(2025-04-30)Approximately 5% of dilated cardiomyopathies are caused by a mutation in the RBM20 gene, which encodes a protein involved in the splicing of cardiac specific titin and formation of cTTNs, the titin specific circRNA. Although ... -
Morphologische und mechanistische Analyse des Wachstums retinaler Ganglienzellen unter Einfluss von Mikrofluidik in vitro
(2025-04-22)Replacing retinal ganglion cells (RGCs) in a degenerated optic nerve is not yet possible but may become feasible in the future through stem cell transplantation. Microfluidic fluid streams, presumably present in the optic ... -
Differentialdiagnostische Abgrenzung des Panayiotopoulos-Syndroms von der Migräne
(2025-04-22)Migraine is among the most common primary headache syndromes in childhood and adolescence. Panayiotopoulos syndrome (PS) (also known as early-onset benign occipital seizure susceptibility syndrome (EBOSS) or self-limited ... -
Gesundheitsbezogene Lebensqualität von Kindern nach Schädel-Hirn-Trauma: Vergleich der Kinder- und Elternperspektive
(2025-04-14)Pediatric Health-Related Quality of Life (HRQoL) as a measure of subjective well-being and functional capacity has gained increasing importance in recent years. However, the HRQoL of children and adolescents following a ... -
AMPK inhibitor-based combination therapies in pancreatic ductal adenocarcinoma
(2025-02-14)Regarding the dismal prognosis of pancreatic ductal adenocarcinoma, this thesis aimed to identify a new therapeutic option by inhibiting the adenosine monophosphate-activated protein kinase (AMPK). Since cancer cells grow ... -
Interaktion zwischen ATG2, ATG9 und WIPI4 und ihre Rolle in der Autophagosommembranbildung
(2025-01-21)Autophagy is a cellular recycling mechanism involved in various physiological functions, such as homeostasis, cellular stress response, and nutrient deprivation. A key step in autophagy is the formation of the autophagosome ... -
Die Bedeutung des Immunoproteasoms in der Behandlung epithelialer Thymustumoren
(2024-10-28)Thymic epithelial tumors are rare neoplastic diseases of the thymus and are divided into thymomas and thymic carcinomas based on their histopathological characteristics. Surgical tumor resection is the first choice of ... -
Pankreatisch zystische Neoplasien und das orointestinale Mikrobiom: Evaluierung als Biomarker
(2024-09-24)Pancreatic cystic neoplasms (PCN) are mostly benign cystic lesions of the pancreas, which can be a precursor lesion for pancreatic cancer. The risk of malignancy varies widely, depending on the entity of the PCN. Despite ... -
Identifikation und Charakterisierung von Typ-II-Neuroblasten im Embryo des Mehlkäfers Tribolium castaneum
(2024-08-16)Evolution has created a wide range of morphological diversity in insect brains, while the basic structure is conserved. Little is known about the mechanisms that lead to this evolutionary diversification of similar structures. ... -
Bedeutung des G-Protein-gekoppelten Estrogen-Rezeptors 1 (GPER1) für die Progression des Vulvakarzinoms
(2024-06-20)The vulvar carcinoma is a gynecological tumor that primarily affects older women. It mostly comprises squamous cell carcinomas. The standard treatment typically involves a triple therapy of radiation, chemotherapy and ...