Browsing Human- und Zahnmedizin by Advisor & Referee "Bleckmann, Annalen Prof. Dr."
Now showing items 1-10 of 10
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NTRK-Alterationen in nicht-kleinzelligen Lungenkarzinomen
(2025-03-31)Alterations, especially gene fusions, of the NTRK gene family, consisting of NTRK1, NTRK2 and NTRK3, represent a rare, but therapeutically potentially addressable driver in non-small cell lung carcinomas. Constitutive ... -
Klinische Validierung hochgradiger MET-Amplifikationen in nicht-kleinzelligen Lungenkarzinomen
(2024-07-18)Lung cancer remains one of the most common types of cancer worldwide. Despite intensive research, the prospects for survival are extremely poor, especially in advanced stages or in the event of metastasis. MET tyrosine ... -
Konsolidierung oder aktive Tumorverkleinerung: Therapeutische Effizienz einer Erhaltungschemotherapie bei hochgradigen Gliomen des Kindes- und Jugendalters
(2024-07-02)High-grade gliomas of childhood and adolescence (pHGG) constitute a heterogenous group of malignant primary tumours of the central nervous system. The prognosis for the majority of pHGG is poor, with only a few therapeutic ... -
Einfluss von SPARC auf den Schweregrad der akuten Pankreatitis in einem genetischen Mausmodell
(2024-06-21)Acute pancreatitis (AP) is a common but severe inflammatory disease that develops upon unspecific acinar cell damage which, via intraparenchymal activation of digestive enzymes, can result in multi organ failure and death. ... -
MET-Alterationen als therapeutisches Target bei metastasierten kolorektalen Karzinomen
(2024-02-09)Introduction: An enhanced understanding of the molecular pathways driving oncogenesis has yielded an increasing number of potential therapeutic targets. MET amplification has been shown to be involved in angiogenesis, ... -
Charakterisierung und Bedeutung extrazellulärer Vesikel im Blut von Patienten mit soliden Tumoren
(2023-07-18)The goal of the study was to analyse tumour-associated extracellular vesicles in the blood of patients with solid tumour diseases and their connection with the clinical progress of the diseases. The vesicles of 330 ... -
Analyse von Markerproteinen für Plasmamembran-abgeleitete Mikrovesikel
(2023-07-05)Cells are known to secrete extracellular vesicles (EVs) into their microenvironment. EVs act as mediators of intercellular communication, can travel long distances, and are involved in various ways in the progression and ... -
Wirbelsäulenmetastasen – Studie zur Inzidenz neurologischer Defizite mit und ohne vorbekannten Primärtumor
(2023-05-31)Spinal metastases are present in up to 10% of patients with malignancies. In patients who present with metastases in the spine, about one fifth have not previously had a known primary tumour. We took these two elements as ... -
Klinische Charakteristika, laborchemische Parameter und deren prognostische Bedeutung für Therapieansprechen und Überleben bei Patienten mit thrombotischen Mikroangiopathien
(2023-01-27)This dissertation deals with the clinical picture of TMA (TTP, STEC-HUS, aHUS and secondary TMA). The first question of the thesis deals with laboratory chemical parameters. This dissertation uncovers some aspects of TMA ... -
FGFR-Alterationen in primären und oligometastasierten kolorektalen Karzinomen
(2020-11-03)The outcome of metastatic colorectal cancer patients is up to now unsatisfactory and there is a need for effective therapeutic options. Fibroblast growth factor receptor (FGFR) and FGF ligand alterations have been investigated ...