Browsing Human- und Zahnmedizin by Advisor & Referee "Katschinski, Dörthe Prof. Dr."
Now showing items 1-20 of 25
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Die Rolle von ERK1/2 im Prozess des kardialen Remodelings während chronischer Volumenbelastung
(2023-11-23)Chronic heart failure is a disease of great socio-economic importance due to its high prevalence, reduced quality of life, poor prognosis and high healthcare costs. The causes of heart failure include hemodynamic stressors, ... -
Characterisation of human ribosome assembly factors
(2023-11-09)Ribosomes are highly conserved ribonucleoprotein complexes for translating the genetic code encoded in mRNAs into functional proteins. In consist of a small and large subunit containing ribosomal RNAs as well as ribosomal ... -
Molecular Basis of Mitochondrial Diseases Exemplified by Mutation of the Translation Factor Cox14
(2023-11-07)Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. More and more evidence shows that mitochondrial ... -
SUMOylierung in Nervenzellen und deren Regulation durch Sauerstoff und Glukose
(2023-04-27)Small ubiquitin-like modifiers (SUMO) are post-translational modifications (PTM) which, similar to Ubiquitin, are conjugated to specific target proteins. The conjugation is based on an energy-dependent enzymatic cascade, ... -
Characterization of the cytosolic and mitochondrial glutathione redox potential using cardiomyocyte specific transgenic Grx1-roGFP2 sensor mice
(2023-01-20)In the field of redox biology, the mainly negative perception of reactive oxygen species has given way to the global concept of an intracellular redox balance. Free radicals like H2O2 not only lead to harmful effects within ... -
Die Bedeutung der Proteinkinase A und der Ca2+/Calmodulin abhängigen Proteinkinase II für das Sarkoplasmatische Retikulum Kalziumleck in der humanen Hypertrophie und Herzinsuffizienz
(2022-09-22)Sarcoplasmic reticulum (SR) Ca2+ leak through ryanodine receptor type 2 (RyR2) hyperphosphorylation is a key pathomechanism in human heart failure (HF). The resulting increased spontaneous diastolic calcium release promotes ... -
TGFbeta und Fibrose der Haut
(2021-06-29)Systemic sclerosis (SSc) is a fibrotic disease characterized by TGFβ-mediated differentiation of dermal fibroblasts to contractile myofibroblasts leading to accumulation of extracellular matrix proteins. Multiple studies ... -
Investigation of genetic and translational effects of tumor suppressor proteins in two hereditary forms of renal cell carcinoma
(2021-05-07)Some familial cancer syndromes are known to cause renal cell carcinoma (RCC) in afflicted subjects. I studied the role of tumor suppressor genes in two syndromes: Birt-Hogg-Dubé (BHD) and von Hippel-Lindau (VHL). BHD is ... -
Strukturelle und funktionale Veränderungen der atrialen Kalzium-Freisetzungseinheit im Herzinsuffizienzmodell durch Junctophilin-2-Knockdown
(2021-03-05)In this work, the effects of a cardiac-specific tamoxifen-mediated junctophilin-2 (JPH2) knockdown in mice on structure and function of the atria and atrial cardiomyocytes (AM) were investigated. Atrial JPH2 protein ... -
Untersuchung des Zusammenhangs zwischen SUMO2/3-Konjugaten und Zellstress in einem In-vitro-Modell
(2020-12-16)Small ubiquitin-like modifiers (SUMO) are small proteins which connect to other proteins through a pathway similar to that of ubiquitin. So SUMO-conjugation is part of the posttranslational modifications. The three main ... -
Membranprotein-Komposition von Kardiofibroblasten in Normoxie und Hypoxie
(2019-10-08)Hypoxia is a key element in the pathophysiology of ischemic, inflammatory and malignant neoplastic diseases. It also plays an essential role in the intrauterine environment during embryonic development as well as in stem-cell ... -
Die Reorganisation des Aktinzytoskeletts in Hypoxie: Neue Erkenntnisse über die Rolle von ArhGAP29
(2019-08-15)Cells can adapt to hypoxia by various mechanisms. Most of them are mediated by HIF-1, the main transcription factor in hypoxia. It was shown that L929 fibroblasts cultivated in hypoxia (1% O2) showed morphological differences ... -
Hypoxia stimulates retrograde membrane trafficking to the trans-Golgi network via recruitment of T-plastin
(2018-10-24)Hypoxia is essential for many physiological functions but also plays a pivotal role in the pathogenesis of a variety of epidemiologically highly relevant diseases. Adequate adaptation mechanisms to oxygen deprivation are ... -
The role of tubulin acetylation in cardiac fibroblasts
(2018-09-25)Cardiac fibroblasts and their activation upon cardiac damage play a key role in pathological cardiac remodelling and the development of cardiac fibrosis. This thesis investigates the role of α-tubulin acetylation in cardiac ... -
Angiotensin II reguliert das Natriumkanal- Öffnungsverhalten über zwei Mechanismen: IP3-Rezeptoren aktivieren die CaMKII und ROS die PKA
(2017-09-19)Background: In heart failure (HF) disturbed CaMKII-dependent sodium current (INa) and sodium channel gating leads to arrhythmias and contractile dysfunction. Enhanced Angiotensin II (Ang II) signaling has been implicated ... -
Einfluss des Prolyl-4-Hydroxylase-Domäne 2-Enzyms auf die Migration der myeloischen Zelllinien RAW und J774
(2017-04-11)HIF-1 is an essential transcription factor for macrophage function, as it usually takes place in hypoxic tissues. It's alpha-subunit is marked oxyxen-dependendly for proteasomal degradation, leading to hypoxic HIF-1alpha ... -
Die Rolle des späten Natriumstroms (late INa) bei Druck-induzierter Hypertrophie und bei Herzinsuffizienz
(2015-03-11)Heart failure, is associated with high mortality as a result of contractile dysfunction (pump failure) or sudden death caused by ventricular arrhythmias. There usually is an imbalance of cellular calcium (Ca2+) and sodium ... -
Funktionelle Charakterisierung der Kalzium/Calmodulin-abhängigen Proteinkinase-II-δ (CaMKIIδ)-Knockout-Maus
(2013-12-03)CaMKII, the Ca2+/Calmodulin-dependent protein kinase-II, is a multifunctional serine/threonine protein kinase that is a central regulator of cardiomyocyte excitation-contraction-coupling. Several isoforms exist. In the ... -
Die Bedeutung der Kalzium/Calmodulin-abhängigen Proteinkinase II für den gestörten Kalziumstoffwechsel der isolierten Rattenherzmuskelzelle unter Doxorubicinbehandlung
(2013-07-08)Doxorubicin (DOX), a member of the anthracycline family, is one of the oldest and most commonly used chemotherapeutic agents. Despite its therapeutic benefits, its cardiotoxic potential, resulting in severe cardiac damage, ... -
Untersuchungen zur Regulation der Zelladhäsion durch PHD2 in Tumorzellen
(2012-07-24)The hypoxia-inducible factor 1 (HIF-1) is a transcription factor, which is stabilized under hypoxic conditions. It consists of the HIF-1β- as well as of one of three known HIF-α-subunits. One of its