Browsing Human- und Zahnmedizin by Advisor & Referee "Ströbel, Philipp Prof. Dr."
Now showing items 1-20 of 50
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Identifikation von immunhistochemischen Biomarkern für die Diagnose von Pankreaskarzinomen
(2025-12-10)The distinction between pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA) is clinically important, as it significantly influences therapeutic decisions, including surgical and adjuvant strategies. ... -
Monozentrische retrospektive Analyse zum Vorliegen eines prognostischen Markers beim Marginalzonenlymphom anhand von klinischen Daten und weiterführender Target-Sequenzierung eines lymphatischen Genpanels.
(2025-11-26)Marginal zone lymphomas are a rare entity within the group of indolent B-cell lymphoma. Prognostic markers for clinical practice are currently only available to a limited extent. This retrospective study examined a monocentric ... -
Analyse des Progressionsrisikos der Monoklonalen Gammopathie unklarer Signifikanz zum Multiplen Myelom anhand immunhistochemischer Marker
(2025-09-17)Background: Monoclonal gammopathy of undetermined significance is a precancerous condition of MM with an annual risk of progression of 1-1.5%. The previously established risk stratification model of the Mayo Clinic is ... -
Proteomische Analyse von nicht-kleinzelligen Lungenkarzinomen
(2025-05-19)Non-small cell lung cancer is a very common disease worldwide with a poor prognosis. Lung cancer is responsible for approximately 1.6 million deaths worldwide each year. A paradigm shift in the treatment of affected patients ... -
Proteomische Analyse des kleinzelligen Lungenkarzinoms
(2025-04-28)Small cell lung carcinoma belonging to the group of neuroendocrine tumors of the lung is an aggressive and rapidly progressing tumor disease with a poor prognosis. Significant progress in the treatment of patients with ... -
NTRK-Alterationen in nicht-kleinzelligen Lungenkarzinomen
(2025-03-31)Alterations, especially gene fusions, of the NTRK gene family, consisting of NTRK1, NTRK2 and NTRK3, represent a rare, but therapeutically potentially addressable driver in non-small cell lung carcinomas. Constitutive ... -
Molekulare Charakterisierung von kolorektalen Lebermetastasen mit unterschiedlichen histopathologischen Wachstumsmustern
(2024-12-12)Colorectal cancer liver metastases express different histopathological growth patterns. The three common ones are the replacement, the desmoplastic, and the pushing histopathological growth patterns. Whereas the both latter ... -
Role of FOXM1, GPX1, and CCNB1 in cisplatin resistance in malignant thymomas and thymic carcinomas
(2024-12-02)Cisplatin resistance in malignant thymomas and thymic carcinomas remains a significant challenge, impairing therapeutic efficacy and patient outcomes. This study investigates the roles of Glutathione Peroxidase 1 (GPX1), ... -
Zur Rolle von EZH2 in neuroendokrinen Neoplasien
(2024-11-29)Neuroendocrine neoplasms are rare neoplasms with an increasing incidence, primarily occurring in the gastroenteropancreatic region and the lungs. They are classified into the prognostically more favorable NET and the less ... -
Untersuchung des unterschiedlichen Therapieansprechens FGFR1-amplifizierter Lungenkrebszellen
(2024-10-28)Lung cancer still continues to be the leading cause of cancer-related death worldwide. While there already exist molecular targeted therapies for the treatment of pulmonary adenocarcinomas molecular targets for squamous ... -
Die Bedeutung des Immunoproteasoms in der Behandlung epithelialer Thymustumoren
(2024-10-28)Thymic epithelial tumors are rare neoplastic diseases of the thymus and are divided into thymomas and thymic carcinomas based on their histopathological characteristics. Surgical tumor resection is the first choice of ... -
Die Rolle der Glykogen Synthase Kinase 3β in der Regulation von DNS-Schäden und Chemotherapieresistenz im Pankreaskarzinom
(2024-09-24)Pancreatic carcinoma is one of the most aggressive solid tumour types and is characterized by pronounced molecular heterogeneity. Research is continuing into molecularly definable subgroups that are suitable for targeted, ... -
Evaluation MikroRNA-basierter Biomarker für das Karzinom der Mundhöhle: hsa-miR-149-5p und hsa-miR-182-5p als neue Prognosemarker
(2024-09-16)Oral squamous cell carcinoma (OSCC) is among the leading cancer types worldwide and a major cause of cancer morbidity and mortality: The 5-year-survival rate remains less than 50% due to high rates of recurrence and lymph ... -
Charakterisierung muriner und humaner Tumoren mit besonderem Fokus auf die Immunzellinfiltration mittels innovativer bildgebender Verfahren
(2024-08-23)3D imaging of the immune cell status in a complex tumour volume represents an important step towards understanding the anti-tumour immune response and a decisive predictor of the efficacy of immune checkpoint inhibition. ... -
Evaluation primärer PDAC-Organoide als Modell zur in-vitro Chemosensitivitäts-Testung
(2024-08-06)Pancreatic ductal adenocarcinoma is one of the most deadly solid tumors. One reason for the poor prognosis despite intensive research in recent years is the difficulty of subtyping and the associated heterogeneity of ... -
Prävalenz und prognostische Bedeutung der FGFR1-Genamplifikation und -Proteinexpression in humanem Lungenkrebs
(2024-08-01)In the past few decades, personalized therapies have severely improved the outcome of patients with advanced-stage lung adenocarcinoma, yet so far the search for similarly druggable molecular targets in squamous cell ... -
Klinische Validierung hochgradiger MET-Amplifikationen in nicht-kleinzelligen Lungenkarzinomen
(2024-07-18)Lung cancer remains one of the most common types of cancer worldwide. Despite intensive research, the prospects for survival are extremely poor, especially in advanced stages or in the event of metastasis. MET tyrosine ... -
Fluoreszenz-in-situ-Hybridisierung und funktionelle Analyse der KMT2A-MAML2 Translokation in epithelialen Thymusneoplasien und den humanen Zelllinien 1889c und MP-57
(2024-04-25)Thymoma and thymic carcinoma are very rare epithelial neoplasms of the thymus. Little is known about the pathogenesis of these tumors. Targeted therapeutic approaches have hardly been established to date, and the recurrence ... -
Regulation and therapeutic targeting of MTHFD2 and EZH2 in KRAS mutated human pulmonary adenocarcinoma
(2023-07-17)With nearly 40 %, pulmonary adenocarcinomas are the main subgroup of non-small cell lung cancers. Activating KRAS mutations occur in about 30 % of pulmonary adenocarcinoma cases and the discovery of the G12C KRAS ... -
Vergleichende immunhistochemische Analyse onkogener Signalwegssignaturen in Lymphomen
(2023-03-03)B-cell lymphomas are a group of malign neoplasms derived from lymphoid B-cells. The targeted therapy of B-cell lymphomas includes the inhibition of oncogene signaling which is mediated via the B-cell receptor (BCR). However, ...