Browsing Human- und Zahnmedizin by Advisor & Referee "Toischer, Karl Prof. Dr."
Now showing items 1-8 of 8
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CRISPR/Cas9 Activation of Delta-like non-canonical Notch ligand 1 (DLK1) to Protect from Contractile Dysfunction in Engineered Human Myocardium
(2025-07-01)Delta-like non-canonical Notch ligand 1 (DLK1) is a gene that is highly upregulated in all three germ layers during the development of the human body, but is almost absent in end-stage heart failure. This work confirmed ... -
Identification of differentially m6A methylated circRNAs in patient derived RBM20 mutated and control iPS-Cardiomyocytes
(2025-04-30)Approximately 5% of dilated cardiomyopathies are caused by a mutation in the RBM20 gene, which encodes a protein involved in the splicing of cardiac specific titin and formation of cTTNs, the titin specific circRNA. Although ... -
Untersuchungen zum Einfluss von Scherspannung, Inflammation und BET-Inhibition auf humane epitheliale Zellen
(2025-01-09)Atherosclerosis is an important cause of some of the most common causes of death, cardiovascular disease. In addition to dyslipidemia, inflammation is one of the key causes of remodeling processes in the endothelium, which ... -
Einfluss der RNA-Demethylase FTO auf die Endothelin-1-induzierte Hypertrophie im hiPSC-Kardiomyozytenmodell
(2023-08-04)Heart failure is a common disease with increasing prevalence. The disease significantly affects quality of life, and mortality and morbidity are high. Current therapies cannot stop the progression of the disease. Therefore, ... -
Kardiale Effekte der m6A-Methylierung auf micro-RNA-Bindung
(2022-09-12)Heart failure is a common syndrome and of huge medial relevance. Increased stress levels lead to an enlargement of cardiomyocytes and the heart becomes hypertrophic. This is accompanied by changes in gene expression and ... -
Zelluläre Elektrophysiologie und Calciumhomöostase an Kardiomyozyten aus induzierten pluripotenten Stammzellen von einem Patienten mit Fallot'scher Tetralogie
(2021-08-26)Introduction: Tetralogy of Fallot (TOF) is the most common congenital cyanotic heart defect and many patients with TOF proceed to suffer from arrhythmias (both atrial and ventricular). The aim of this thesis was to identify ... -
Über die potenziell kardioprotektive Rolle des Hitzeschockproteins A4
(2020-08-06)Background: The protein quality control (PQC) plays a crucial role in cellular homeostasis. Accumulation of misfolded proteins can lead to a loss of function of cardiomyocytes and thus can contribute to heart failure. A ... -
Die Rolle des Protein-Phosphatase-1-Inhibitor-1 in der β-adrenergen Signalkaskade kardialer Fibroblasten
(2019-03-26)Heart failure is among the most common internal diseases in industrialized nations and associated with a high mortality rate. The sympathetic nervous system and β-adrenergic signaling play a crucial role in the pathophysiology ...