Browsing Human- und Zahnmedizin by Advisor "Bayer, Thomas A. Prof. Dr."
Now showing items 1-16 of 16
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Die Bedeutung des Pyroglutamat-Abeta-Oligomer-Blutplasmaspiegels und des Apolipoprotein-E-Genotyps bei der Alzheimer-Krankheit
(2012-04-04)Alzheimer's Disease is a severe neurodegenerative disorder and the most common of the worldwide 24 million cases. The characteristics are, besides the clinical manifestation, neuropathological hallmarks like deposits ... -
Der Einfluss von Aβ4-42 auf die Kognition und die Anwendung von Suchstrategien im Morris Water Maze im Tg4-42-Mausmodell
(2024-03-25)The relevance of Alzheimer's dementia for our society is increasing. Soluble amyloid beta (Aβ) plays a particularly important role in the genesis of this disease. Aβ4-42 in particular, which is truncated before the fourth ... -
Exosomes act as molecular vehicles contributing to cellular cholesterol efflux
(2011-02-11)Exosomes are small vesicles of 50-100 nm diameter that derive from intraluminal vesicles (ILVs) and are secreted into the extracellular environment upon fusion of multiversicular bodies ... -
Die Funktionsanalyse und Pharmakomodulation des Amyloid-Vorläufer-Proteins (APP) in vitro und in vivo - Eine neue Zielstruktur zur Behandlung maligner Tumore
(2012-02-28)The ß-amyloid precursor protein (APP) represents a type I transmembrane glycoprotein that is ubiquitously expressed in neuronal as well as in non-neuronal cells. In brain it is a key player ... -
Neuropathological and behavioral alterations in two transgenic mouse models of Alzheimer´s disease
(2016-07-05)According to the influential amyloid cascade hypothesis cerebral accumulation of Aβ is the key event in the pathogenesis of Alzheimer´s disease. Aβ deposits occur as soluble forms, as well as insoluble forms. It is assumed ... -
Neuropathologische und verhaltensbiologische Untersuchungen an transgenen Alzheimer-Mausmodellen bezüglich des Angstverhaltens
(2011-06-29)Multiple studies have shown that there is a high prevalence of anxiety disorders and depression in patients with Alzheimer`s disease. An altered anxiety behaviour has also been observed in ... -
Passive Immunisierung mit dem monoklonalen Antikörper NT4X am Tg4-42-Mausmodell für die sporadische Form der Alzheimer Erkrankung
(2023-01-27)Alzheimer´s dementia is a chronic-progressive neurodegenerative disease that can lead to extensive impairments in the daily life of affected patients due to pronounced cognitive impairments. Significant neuropathological ... -
Passive Immunisierung mit einem N-trunkierten Abetaspezifischen Antikörper - Therapeutisches Potential von NT4X in einem familiären Alzheimer-Mausmodell
(2019-03-25)Abstract Alzheimer’s disease is a progressive neurodegenerative illness whose patients suffer from memory loss, problems managing everyday life and increasing helplessness. Worldwide there is a prevalence of over 47 ... -
Pathologische Veränderungen im Thalamus in einem Tiermodell für die Alzheimer-Krankheit
(2010-09-14)The accumulation of beta-amyloid (A beta) plaques and neurofibrillary tangles consisting of hyperphosphorylated tau protein are pathological features of Alzheimer's disease (AD) commonly ... -
Role of amyloid beta protein modulation in Alzheimer's disease
(2012-07-17)Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. It is mainly characterized by the deposition of amyloid plaques and neurofibrillary tangles. In addition, inflammatory processes in ... -
Studie zur Rolle N-trunkierter Amyloid-β-Peptide bei der Alzheimer-Krankheit
(2019-10-15)Alzheimer’s disease (AD) is a neurodegenerative progressive disease, characterized by extracellular amyloid accumulation, neurofibrillary tangles and neuron loss. N-terminally truncated Aβ4-42 and pyrog ... -
Therapiemöglichkeiten der Alzheimer-Krankheit durch passive Immunisierung mit dem NT4X-Antikörper im Tg4-42hom-Mausmodell
(2017-07-05)Aβ4-42 is one of the major variants of beta-amyloid (Aβ) in the Alzheimer brain and one of the earliest to appear in the development of the disease. It shows an increased aggregation tendency and toxicity. Furthermore it ... -
Untersuchung der Wirkung von HDAC-Inhibitoren auf das Amyloid-Vorläufer-Protein (APP) in Tumorzellen
(2013-09-18)The ß-amyloid precursor protein (APP) is an integral membrane protein, which is expressed in neuronal and non-neuronal human cells. In addition to its well-known relevance in the pathogenesis of Alzheimer’s disease, APP ... -
Untersuchung genetischer und geschlechtlicher Einflüsse in der Alzheimerpathologie anhand des Maustiermodells 5XFAD
(2010-10-27)The Alzheimer´s Disease is the most frequent dementia. In Germany are approximately 900.000 individuals affected. Although there are great efforts to investigate the pathogenesis, there is ... -
Untersuchungen über die Auswirkungen von Geschlecht und genetischem Hintergrund auf die Alzheimerpathologie im 5xFAD-Mausmodell
(2015-06-10)Alzheimer's disease (AD) is the most prevalent cause of dementia in the industrial nations. It leads to a constant decline of cognitive capabilities to the point of entire need of care. Since every fifth person over 90 ... -
Untersuchungen zu synaptischen Proteinen in einem Tiermodell für die Alzheimer-Krankheit
(2011-07-05)Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common cause of dementia. Extracellular senile plaques, neurofibrillary tangles as well as axonal and synaptic ...