Blättern Human- und Zahnmedizin nach "Burckhardt, Birgitta-Christina Prof. Dr." Betreuer
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Einfluss des extrazellulären pH-Werts auf den Transport von para-Aminohippurat über den organischen Anionentransporter 1
(2015-02-10)Organic anion transporter 1 (OAT1) is one of the transporters responsible for renal elimination of organic anions. In the present study, the influence of extracellular pH on the transport-activity of OAT1 was examined using ... -
Einfluss von Transforming Growth Factor - beta 1 (TGF-β1) und Hypoxie auf die Expression von Sulfattransportern (SAT-1 und NaSi-1) in den humanen renalen Zelllinien TK173 und TK188
(2011-08-01)Renal fibrosis as a consequence of a variety of primary diseases such as diabetes mellitus and arterial hypertonus is based on a production of extracellular matrix (ECM) by fibroblasts. ... -
Einflüsse der Serum- und Glukokortikoidkinasen 1 und 3 auf den humanen Na⁺- Dikarboxylat- Transporter NaDC3
(2017-08-15)NaDC3 is responsible for the uptake of dicarboxylates necessary for the organic anion-dicarboxylate exchange via the organic anion transporters 1 and 3 (OAT1 and 3) that contribute to renal excretion. It is assumed that ... -
Elektrophysiologische Charakterisierung eines Betain/GABA-Transporters
(2011-07-18)Background: The cells in the renal medulla are exposed to high osmolarities during urine concentration. Betaine and g-aminobutyric acid (GABA) are important osmolytes which prevent cell ... -
Elektrophysiologische Untersuchungen von Transporteigenschaften des Natrium-Dikarboxylat-Kotransporters aus der Flunderniere
(2008-10-02)The goal of this thesis was a deeper electro-physiological characterization of the Sodium-Dicarboxylate-Cotransporter from the kidney of the winterflounder (fNaC3). Both the wild type and ... -
Die Expression von Sulfattransportern als Funktion einer fortschreitenden Nierenfibrose am Modell der Alport-Maus
(2012-01-13)The system of sulfate metabolism and the expression of sulfate transporters in kidney and liver tissue are influenced by various parameters. The focus of this thesis lies on the sulfate ... -
Interaktion des hNaDC3 mit Fumarat und Fumaratderivaten
(2013-04-22)Human NaDC3 is one of the five members of the “solute carrier 13 (SLC13)” gene family, all of them coding for electrogenic sodium-coupled transporters on plasma membranes. Transcripts of hNaDC3 have been detected in renal, ... -
Interaktion des NaDC3 und des NaCT mit Carbaglu, einem Medikament zur Behandlung der Hyperammonämie
(2017-10-27)Primary or secondary N-acetylglutamate synthase (NAGS) deficiency leads to the reduction of N-acetylglutamate (NAG), the natural activator of the urea cycle. It results in hyperammonemia. Hyperammonemic crises can be ... -
Interaktionen von Diuretika mit dem humanen Natrium-abhängigen Dikarboxylat-Transporter (hNaDC-3)
(2012-02-15)Due to their high protein binding, diuretics are tubular secreted. This process takes place in the proximal tubular cells of the kidney via the organic anion transporters hOAT1 and hOAT3, ... -
Die pH-Abhängigkeit des NaDC3-Transporters
(2017-11-27)The sodium-dependent dicarboxylate transporter 3 (NaDC3) is located close to organic anion transporters (OAT) in the basolateral membrane of renal proximal tubule cells. The transport-activity of OAT1 (p-aminohippurate) ... -
Regulation des Sulfat-Anionen-Transporters-1, sat-1, in Caco2-Zellen durch Oxalat und dessen Vorstufen
(2014-11-25)Nephrolithiasis is a major health problem caused by hyperoxaluria. The sulfate anion transporter-1 which transports sulfate and oxalate might be involved in the development of hyperoxaluria, so further information concerning ... -
Die Regulation des Sulfat-Anionen-Transporters-1, sat-1, in HepG2- Zellen in Abhängigkeit vom pH-Wert und von Bicarbonat
(2019-10-14)Sulfate is an essential component of the human organism and the fourth most abundant anion in the blood. It is involved in numerous metabolic processes like biosynthesis, synthesis of the extracellular matrix and the bone ... -
Strukturwirkungsbeziehungen am Na+-abhängigen Dicarboxylat-Cotransporter 3(hNaDC3)
(2013-06-24)This experimental study investigates the interactions between various substances (succinate, glutamate, glutathion, glycine, cysteine, fumarate, N-oxalyl glycine, glycylglycine) and the sodium-dicarboxylate cotransporter-3 ... -
Untersuchung der Transportvorgänge des Prolyl-Hydroxylase-Hemmers ICA an den Transportern OAT1, OAT2, OAT3 und OAT4 von proximalen Nierentubuluszellen
(2017-10-27)This thesis discusses the interactions between ICA and the organic anion transporters OAT1, OAT2, OAT3 and OAT4. ICA is a substance which can inhibit the prolyl hydroxylase domain. This leads to an upregulation of hypoxia ... -
Untersuchungen zur Chloridabhängigkeit des Sulfat-Anionen-Transporters 1
(2013-04-23)The sulfate-anion-transporter-1 is localized in the basolateral membrane of the proximal tubular cells and the sinusoidal membrane of hepatocytes. Earlier studies showed species differences with respect to chloride transport ...