Browsing Human- und Zahnmedizin by Advisor "El-Armouche, Ali Prof. Dr."
Now showing items 1-5 of 5
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Analyse des antifibrotischen Potenzials der betaadrenergen Signalkaskade und des PKA-Effektors Protein-Phosphatase-Inhibitor-1
(2017-05-17)The fibrotic remodeling of the heart appears in several cardiac diseases. Especially fibroblasts, which are known as the tissue producing cells in the heart, contribute to this process. Interacting with cardiomyocytes they ... -
Effekte einer chronischen β-Adrenozeptor-Blockade auf die Aktivität der Calcium-Calmodulin-Kinase II in der Herzinsuffizienz
(2018-01-22)Heart failure is one of the leading causes of mortality worldwide. Despite major advances in the understanding of heart failure pathophysiology and significant progress in the development of therapeutic concepts, the ... -
Kardiale Phänotypisierung einer transgenen Mauslinie mit herzspezifischer Calcium-Calmodulin-Kinase IIδc- Überexpression auf einem Phosphatase-Inhibitor-1- Knockout-Hintergrund
(2015-09-29)Since years cardiovascular diseases are the leading cause of death in our population. In particular heart failure is of considerable importance. So, to understand molecular alterations in signal transduction and to identify ... -
Rolle der Phosphodiesterase 2 in der menschlichen und experimentellen Herzinsuffizienz
(2017-09-14)Background: Cyclic nucleotide phosphodiesterases (PDEs) compromise a family of cyclic-nucleotide hydrolysing enzymes, controlling the levels of cAMP and cGMP in a highly specific and stimulus-dependent manner. Amongst them, ... -
Die Rolle des Protein-Phosphatase-1-Inhibitor-1 in der β-adrenergen Signalkaskade kardialer Fibroblasten
(2019-03-26)Heart failure is among the most common internal diseases in industrialized nations and associated with a high mortality rate. The sympathetic nervous system and β-adrenergic signaling play a crucial role in the pathophysiology ...