Blättern Human- und Zahnmedizin nach "Katschinski, Dörthe Prof. Dr." Betreuer
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Characterization of the cytosolic and mitochondrial glutathione redox potential using cardiomyocyte specific transgenic Grx1-roGFP2 sensor mice
(2023-01-20)In the field of redox biology, the mainly negative perception of reactive oxygen species has given way to the global concept of an intracellular redox balance. Free radicals like H2O2 not only lead to harmful effects within ... -
Chemoresistenz als Folge einer Inhibition der zellulären Sauerstoffsensoren (Prolyl-4-Hydroxylase-Domäne)
(2011-10-18)The hypoxia-inducible factor (HIF) is the master regulator for oxygen-dependent gene expression. The HIF signal transduction pathway can be manipulated by inhibiting the activity of the ... -
Einfluss des Prolyl-4-Hydroxylase-Domäne 2-Enzyms auf die Migration der myeloischen Zelllinien RAW und J774
(2017-04-11)HIF-1 is an essential transcription factor for macrophage function, as it usually takes place in hypoxic tissues. It's alpha-subunit is marked oxyxen-dependendly for proteasomal degradation, leading to hypoxic HIF-1alpha ... -
Etablierung und Charakterisierung einer Tetracyclin-induzierbaren PHD2-Knockdown-HeLa-Zelllinie
(2010-07-15)Prolyl-4-Hydroxylase Domain (PHD) enzymes 1-3 are oxygen-dependent enzymes, which hydroxylate the hypoxia-inducible factor (HIF) and target it for proteasomal degradation. HIF-1 is the ... -
Hypoxia stimulates retrograde membrane trafficking to the trans-Golgi network via recruitment of T-plastin
(2018-10-24)Hypoxia is essential for many physiological functions but also plays a pivotal role in the pathogenesis of a variety of epidemiologically highly relevant diseases. Adequate adaptation mechanisms to oxygen deprivation are ... -
Die Reorganisation des Aktinzytoskeletts in Hypoxie: Neue Erkenntnisse über die Rolle von ArhGAP29
(2019-08-15)Cells can adapt to hypoxia by various mechanisms. Most of them are mediated by HIF-1, the main transcription factor in hypoxia. It was shown that L929 fibroblasts cultivated in hypoxia (1% O2) showed morphological differences ... -
Untersuchungen zur Regulation der Zelladhäsion durch PHD2 in Tumorzellen
(2012-07-24)The hypoxia-inducible factor 1 (HIF-1) is a transcription factor, which is stabilized under hypoxic conditions. It consists of the HIF-1β- as well as of one of three known HIF-α-subunits. One of its