Blättern Human- und Zahnmedizin nach "Lingor, Paul Prof. Dr." Betreuer
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Effects of the microRNA cluster 132/212 in primary dopaminergic neurons
(2021-02-19)The microRNA (miRNA) cluster 132/212 is highly involved in the regulation of cell growth and maturation in neurons and other cell types. This work investigated effects of increased levels of the miRNA strands miR-132-3p ... -
Kombinationsbehandlung mit Fasudil und Riluzol im SOD1-G93A-Mausmodell der Amyotrophen Lateralsklerose
(2018-03-26)The aim of this study was to test the beneficial effects of the Rho-Kinase inhibitor Fasudil on an established animal model, in which more than one hundred studies with different test substances had already been performed ... -
Pharmakologische Inhibition von Rho-Kinase im Mausmodell der Amyotrophen Lateralsklerose
(2015-06-12)Since the development of Riluzol no substance, which had been successfully tested in a preclinical setting before, has been able to be successful as a disease modifying drug in human ALS although there has been enormous ... -
Regulation des Autophagieproteins ULK1 im MPTP-Mausmodell des Morbus Parkinson
(2022-11-08)Parkinson’s disease (PD) is a widespread neurodegenerative condition. Owing to the absence of suitable biomarkers, a diagnosis can only be made upon onset of clinical symptoms like tremor, rigidity or bradykinesia. They ... -
Role of autophagic protein ULK1 in axonal degeneration and regeneration in rat cortical neurons in vitro
(2021-11-02)In many traumatic and neurodegenerative disorders of the central nervous system, axonal degeneration is a central and early pathophysiological feature. Since the regenerative response of injured neurons is severely hampered ... -
Tränenflüssigkeit als mögliche Quelle für Biomarker bei Patienten mit einem idiopathischem Parkinson-Syndrom
(2022-03-21)Idiopathic Parkinson's disease is the second most common neurodegenerative disorder worldwide with a growing prevalence in the continuously aging population. Until today, the diagnosis of Parkinson's disease is mainly based ...