Browsing Human- und Zahnmedizin by Advisor "Moser, Tobias Prof. Dr."
Now showing items 1-9 of 9
-
Bacteriorhodopsin-like cation channelrhodopsin based optogenetic tools for the future optical cochlear implant
(2025-05-07)Deafness is a widespread and severe condition. Electrical cochlear implants, which use electrical stimulation of the auditory nerve, enable speech comprehension in those patients suffering from sensorineural hearing loss. ... -
Optical Measurement of Glutamate Release at a Fast Central Synapse
(2025-04-02)Recent advances in the development optogenetic indicators have enabled optical measurements of neurotransmitter release and dynamics in the synaptic cleft. The precise information about spatial and temporal neurotransmitter ... -
Optogenetic characterization of targeting-optimized Chronos and f-Chrimson variants for auditory encoding in mice
(2024-12-03)Electrical cochlear implants bypass the physiological micromechanics and synaptic sound encoding by sensory hair cells in the cochlea and provide state-of-the-art treatment of sensorineural hearing loss. To overcome the ... -
Age-dependent alterations of medial olivocochlear efferent synapses in the murine cochlea
(2024-10-11)Age-related hearing loss, also referred to as presbycusis, is defined as bilateral, symmetrical sensorineural hearing loss caused by age-related alterations of the auditory system. Previous studies on ARHL have investigated ... -
Molekulare und elektrophysiologische Untersuchung der Exozytose in der Maus-Cochlea
(2023-12-20)The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, I studied the role of Rab3 ... -
Hörphysiologische Charakterisierung zweier Mausmodelle mit Schwerhörigkeit
(2021-11-11)In this work, two transgenic mouse models were characterized that showed disruption either of presynaptic Ca2+-influx (CaVβ2) in inner hair cells or of the cochlear K+-cycle (Cx26) by targeted mutagenesis. Approaches of ... -
Gene Transfer Into the Inner Ear
(2019-10-21)In humans, in whom speech and speech perception is essential for communication and social interaction, deafness is a severe disorder. One of the genetic non-syndromic forms is the autosomal recessive nonsyndromic deafness ... -
Electroretinography and exploration of visual and auditory function in mutant mice with synaptic defects
(2012-11-05)At the outset of this work, fundamentals of retinal physiology and electroretinograhy are presented. Scotopic electroretinographic measurements and analyses were performed on two different knockout mouse mutants. One of ... -
Einfluss von Rapamycin auf Myelinmissbildungen in einem Mausmodel einer tomakulösen Neuropathie
(2010-02-05)Tomacula and other forms of focally folded myelin are striking neuropathological features of a diverse group of demyelinating neuropathies, including Charcot-Marie-Tooth (CMT) 4B, CMT4F, CMT1B and hereditary neuropathy ...