Browsing Human- und Zahnmedizin by Advisor "Nau, Roland Prof. Dr."
Now showing items 1-20 of 21
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Activation of murine microglial cells by muramyl dipeptide alone and in combination with Toll-like receptor agonists
(2014-09-25)Meningitis, meningoencephalitis and sepsis are severe diseases causing many deaths all over the world every year. Escherichia coli (E. coli) is the most common Gram-negative bacterium causing neonatal meningitis and sepsis ... -
Activin A und Follistatin bei bakteriellen Infektionen - Der Einfluss von Activin A auf Mikrogliazellen in vitro und der Einfluss von Follistatin auf den Verlauf einer E. coli-K1-Sepsis im Mausmodell
(2012-10-01)High concentrations of Activin A and Follistatin can be found in the cerebrospinal fluid (CSF) of patients with bacterial meningitis. Patients suffering from a sepsis have increased concentrations of Activin A and Follistatin ... -
Additiver Mikroglia-vermittelter Neuronenschaden durch β-Amyloid und bakterielle Toll-like-Rezeptor-Agonisten in primären murinen Mikroglia-Neuronen-Kokulturen. Entwicklung eines Auswertungsalgorithmus zur Quantifizierung des Neuronenschadens mit Hilfe einer Software zur objektorientierten Bildanalyse
(2012-06-06)Activated microglia is considered to be involved in the progression of Alzheimer´s dementia (AD). We investigated the effect of Aβ40 and exogenous agonists of TLR1/2 [Pam3CSK4] and TLR4 [LPS] on neurons in primary ... -
Anwendung von Inhalatoren und hierdurch bedingte Symptomkontrolle sowie Verbesserung der Lungenfunktion bei geriatrischen Patienten mit chronisch-obstruktiver Lungenerkrankung
(2022-03-08)Purpose The use of inhalers requires a high degree of fine motor skills and coordination, which is particularly difficult for elderly patients suffering from chronic-obstructive pulmonary disease (COPD). Many of these ... -
Auswirkung von Glycopyrronium auf die Phagozytose von Streptococcus pneumoniae und Escherichia coli durch Makrophagen und Mikrogliazellen
(2021-11-10)Streptococcus pneumoniae and Escherichia coli are responsible for a wide variety of life-threatening infections such as pneumonia, sepsis, and meningitis. Multi-resistant pathogens are spreading more and more despite the ... -
Beeinflussung der Phagozytose von Pneumokokken durch Mikrogliazellen mit Anticholinergika
(2013-12-16)Streptococcus pneumoniae is the most common pathogen causing bacterial meningitis. Despite all efforts using the treatments available, pneumococcal meningitis proves fatal in 25 % of cases. Increasing resistance to ... -
Beeinflussung des Verlaufs von Pneumokokken-Meningitis in Mäusen durch Stimulation mit einem Cytosin-Guanin-haltigen Oligonukleotid
(2020-01-28)Streptococcus pneumoniae is the most common cause of bacterial meningitis in small children, the elderly and in immunocompromised patients. The aim of this study was therefore, to test if a single intraperitoneal injection ... -
Beeinflussung des Verlaufs von ZNS-Infektionen in immundefizienten Mäusen durch Immunstimulanzien
(2013-10-30)Escherichia coli is the leading cause of Gram-negative meningitis in infants and can also cause meningitis and meningoencephalitis in old and immunocompromised patients. In this doctoral thesis we studied the contribution ... -
Dosisabhängige Aktivierung von Mikrogliazellen durch Toll-like - Rezeptoragonisten allein und in Kombination
(2013-08-22)We investigated the effects of treatment from murine microglial cells with agonists of TLR2, TLR4 and TLR9. For this reason murine microglial cell cultures were applied. We used the TLR agonists Pam3Cys, HKAL (TLR2), ... -
Einfluss einer intrazerebralen Infektion mit Streptococcus pneumoniae auf den Verlauf der Alzheimer-Demenz im Mausmodell
(2012-06-18)A well known clinical phenomenon, that has been proved in earlier studies, is the deterioration of the clinical-neurological and neuropsychological status in patients with Alzheimer`s disease (AD). Based on this studies ... -
Einfluss systemischer Infektionen und ihrer Behandlungen auf den Krankheitsverlauf im Maus-Modell des Morbus Parkinson
(2011-06-29)Neurodegenrative diseases such as Parkinson s disease are known to be among the prevalent diseases of this kind. Often they tend to deteriorate during acute infections e.g. excited through ... -
Immunreaktionen im zentralen Nervensystem bei Stimulation mit Bestandteilen von Borrelia burgdorferi
(2014-01-06)Stimulation of the CNS in vivo and in vitro with proteins from Borrelia burgdorferi. -
Neurogenese und Apoptose im hippokampalen Gyrus dentatus bei Autopsiefällen nach hypoxischem Hirnschaden und Subarachnoidalblutung
(2008-11-26)Hypoxic-ischemic encephalopathy (HIE) is the leading cause of morbidity and mortality after successful resuscitation efforts and results in neuronal loss within the neocortex and the ... -
Prävalenz, Antibiotikaresistenz und klinische Relevanz einer Besiedlung des Respirationstraktes mit Streptococcus pneumoniae in einer geriatrischen Klinik
(2020-11-25)Colonization of the pharynx by Streptococcus pneumoniae was studied in 185 in-hospital geriatric patients (median age 81 years) from 29 March 2011 to 22 June 2011. Swabs were plated on blood agar plates. Colonies with a ... -
Psychopharmaka und das Risiko von Stürzen in der stationären geriatrischen Versorgung
(2019-08-15)Abstract OBJECTIVE: To examine the impact of medication and medical conditions on the fall risk in older hospitalized patients. DESIGN: Matched case-control study. SETTING: Large regional hospital in a mid-sized ... -
Quantifizierung der Freisetzung bakterieller DNA in Modellen experimenteller bakterieller Meningitis
(2012-10-25)Bacterial meningitis is still a quite severe illness which is associated with local and systemic inflammation and can cause long-term neurological sequelae or death. Common bacteria causing meningitis in Germany are ... -
Regulation der mRNA von Toll-Like-Rezeptoren bei experimentellen ZNS-Infektionen
(2012-11-20)Regulation of the mRNA of toll-like receptors in experimental CNS infections Toll-like receptors are sensors and regulators of innate immunity. We investigated the expression of TLRs in experimental infections with ... -
Die Rolle verschiedener Virulenzfaktoren von Streptococcus pneumoniae bei der Meningitis: Untersuchung am Mausmodell
(2015-09-11)The present study examines virulence factors of S. pneumoniae in mouse model. After intracerebral injection virulence factors of D39-wild-type S. pneumoniae were compared with isogenetic derivates. These infection strains ... -
Sequentielle Antibiose mit Rifampicin gefolgt von Ceftriaxon als neuroprotektiver Therapieansatz bei der bakteriellen Meningitis
(2016-06-24)Abstract OBJECTIVE: In bacterial meningitis, severe systemic and local inflammation causes long-term impairment and death of affected patients. The current antibiotic therapy relies on cell wall-active beta-lactam ... -
Über die Auswirkungen systemischer bakterieller Begleitinfektionen bei Amyotropher Lateralsklerose
(2007-12-12)Bacterial Infections can aggravate the symptoms in amyotrophic lateral sclerosis probably due to release of bacterial toxins and activation of microglial cells. In the present thesis it is ...