Browsing Human- und Zahnmedizin by Advisor "Schirmer, Markus Dr."
Now showing items 1-4 of 4
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Functional Assessment of Biomarkers in Gemcitabine-Treated Pancreatic Cancer with Specific Focus on Nucleoside Transporter ENT1
(2013-10-31)Pancreatic ductal adenocarcinomas are the fourth leading cause of death among all kinds of cancers. The poor prognosis is due to usually late diagnosis and, in most cases, the available therapeutic options lack sustained ... -
Genetisch bedingte Variabilität der Expression von Genen des TGFß-Signalwegs und deren Bedeutung für die Zellvitalität: Untersuchungen in T-Lymphozyten, immortalisierten B-Lymphozyten und Fibroblasten
(2013-01-29)The TGFbeta pathway is involved in a huge number of biological functions and, hence, relevant for a plethora of clinical disorders. A major function of this pathway is its contribution to fibrotic conditions as it may ... -
Funktionelle und genetische Variabilität bei der zytotoxischen Wirkung von Nukleosid-Analoga
(2012-04-19)The objekt of this work was the detection of genetic polymorphisms which impact the efficacy of gemcitabine and cytarabine, two nucleoside analogues employed as cytostatic drugs in treatment of cancer. As investigational ... -
Oxidativer Stress als Biomarker für die (Neben-) Wirkungen von Strahlentherapie: Bestimmung von Isoprostanspiegeln und Genexpressionsprofilen in Patientenproben
(2011-11-14)Radiotherapy is used to treat prostate cancer as well as locally advanced rectal cancer within a preoperative chemoradiotherapy. To understand the causal relationship between the effect of ...