Blättern Human- und Zahnmedizin nach "Wienands, Jürgen Prof. Dr." Betreuer
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B Cell Antigen Receptor-intrinsic Costimulation of IgG and IgE Isotypes
(2012-06-27)B cells express different isotypes of the B cell antigen receptor (BCR) on their surface and secrete soluble forms of their antigen binding immunoglobulins (Ig) upon differentiation to plasma cells. Naïve mature B cells ... -
CIN85/CD2AP-based protein complexes in B cell antigen receptor signalling
(2012-07-12)Early B cell antigen receptor (BCR) signal transduction involves formation of multimeric protein complexes and their recruitment to BCR-containing areas in the plasma membrane. One such membrane-targeted signalosome is the ... -
Die Organisation von Signalnetzwerken in B-Lymphozyten
(2012-07-17)B cell antigen receptors (BCR) transduce signals that regulate not only proliferation and differentiation processes but also apoptosis. To regulate such a variety of biological responses BCR employ complex and tightly ... -
Regulation der „spleen tyrosine kinase“ Syk im B-Zell-Antigen-Rezeptor-Signalweg
(2013-11-25)The “spleen tyrosine kinase” Syk offers transducer functions for a number of ITAM-based immune cell receptors and is critical for the development and activation of B lymphocytes. Furthermore Syk has been implicated in the ...