Browsing Human- und Zahnmedizin by Advisor "Wirths, Oliver Prof. Dr."
Now showing items 1-4 of 4
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Auswirkung von Enriched Environment auf hippocampalen Nervenzellverlust und Gedächtnisfunktionen im Mausmodell Tg4-42
(2023-02-27)N-truncated Aβ4-42 is one of the Aβ isoforms most frequently present in the brains of patients suffering from Alzheimer's disease. It exhibits an increased propensity for aggregation and increased toxicity, which can lead ... -
Quantitative Analysen hippocampaler Interneuronen in zwei transgenen Alzheimer Mausmodellen
(2022-09-20)Characteristic pathologies of Alzheimer's disease are extracellular amyloid plaques, early intracellular Aβ accumulation and marked neuronal loss. The Tg4-42 mouse model expresses the Aβ4-42 peptide, which accumulates ... -
Analyse neurodegenerativer Prozesse im Gyrus Dentatus im Tg4-42-Mausmodell der Alzheimerdemenz
(2018-03-27)Alzheimer's disease is a neurodegenerative disease and the most common form of dementia. Hyperphosphorylated tau and extracellular Aβ deposits are classical neuropathological hallmarks of AD. In addition to extracellular, ... -
C-terminally truncated Amyloid-β peptides in Alzheimer’s dementia: Deposition of Aβ37, Aβ38, and Aβ39 in the brains of patients with sporadic and familiar Alzheimer’s dementia and in transgenic mouse models.
(2018-01-24)Alzheimer's dementia is a devastating neurodegenerative disease characterized by profound neuropathological changes of the brain. Imbalances in the production of aggregation-prone Amyloid-Beta Peptides are believed to play ...