Browsing Human- und Zahnmedizin by Advisor "Zeisberg, Elisabeth Prof. Dr."
Now showing items 1-6 of 6
-
Characterization of the cardiogenesis in embryos of a Gse-1tm-1a(EUCOMM)Wtsi mouse line
(2021-07-16)HLHS is classified as a cyanotic heart disease, which accounts for 25% of all CHD mortalities. It is the leading cause of death in infants under the age of one year. One human candidate gene called KIAA00182 (Gse-1 in mice) ... -
Epigenetische Suppression von RASAL1 und ATP2A2 als Biomarker und Therapieansatz bei kardialer Fibrogenese
(2020-07-10)Chronic heart diseas constitutes a growing medical challenge on a global scale. It is associated with cardiac fibrosis - the accumulation of extracellular matrix produced by persistently activated fibroblasts. Epigenetic ... -
Etablierung von zirkulierenden DNA-Fragmenten als Biomarker für die klinische Progression einer Herzinsuffizienz mit erhaltener Ejektionsfraktion
(2020-02-21)Chronic heart disease is associated with abberant CpG promoter methylation, mechanistically involved cardiac fibrogenesis. Aberant CpG promoter methylation is equally reflected in corresponding blood samples („liquid ... -
‘Knockout-first’ mouse model as a biological tool to study the role of KIAA0182 gene in hypoplastic left heart syndrome
(2016-03-08)Objective: Hypoplastic left heart syndrome (HLHS) is one of the most severe congenital heart diseases. The genetic etiology for this syndrome was strongly suggested by several previous studies, and a lot of genes were ... -
Die Rolle von Gse1 in der embryonalen Hämatopoese der Maus
(2021-07-27)Objective: To investigate a possible involvement of the gene KIAA0182 in the pathogenesis of hypoplastic left heart syndrome (HLHS), a knockout mouse was generated for previous studies using the knockout-first strategy for ... -
Sekundärprävention und stationärer Verlauf von Patienten mit koronarer Herzerkrankung zwei Jahre nach stationärer Anschlussheilbehandlung
(2018-10-18)BACKGROUND The recently published EUROASPIRE IV study demonstrated that a large majority of coronary patients do not achieve the guideline standards for secondary prevention. High prevalences of persistent smoking, unhealthy ...