Browsing Human- und Zahnmedizin by Referee "Alves, Frauke Prof. Dr."
Now showing items 1-14 of 14
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Analyse von Mikrosatelliteninstabilität und hMSH2-Expression bei Patienten mit akuter myeloischer Leukämie
(2017-06-12)Acute myeloid leukemia, the most common acute leukemia in adults, is a malignant, genetically heterogeneous, clonal disorder, which is based on haemopoietic progenitor cells with a disrupted ability of self-renewal, ... -
Auswirkung von ACE-Hemmern auf die Nierenfunktion bei hereditären Nierenerkrankungen wie dem Alport-Syndrom im Mausmodell
(2022-04-22)Alport syndrome is a hereditary kidney disease that leads to the development of progressive kidney failure. It is based on mutations in the COL4 genes. Homozygous or hemizygous patients develop the disease earlier and more ... -
Cartilage Adjacent Subchondral Bone in Ageing and Disease as a Diagnostic and Therapeutic Target
(2021-05-06)Osteochondral unit is emerging as a focal point in osteoarthritis (OA) research, with subchondral bone (SB) attracting more attention as a critical contributing factor to the initiation and progression of OA. In particular, ... -
Die Charakterisierung der induzierbaren Stickstoffmonoxidsynthase im murinen RENCA-Nierenzellkarzinommodell unter spezieller Berücksichtigung tumorassoziierter Makrophagen, der Gefäßdichte und Tumorhypoxie
(2013-03-06)Objective. To characterize a murine renal cell carcinoma model considering hypoxia inducible tumor necrosis, macrophage infiltration as well as expression and activity level of iNOS. Methods. In vitro cultivated RENCA-cells ... -
Der Einfluss von Rab5c auf die Ciliogenese bei chondrogenen Progenitorzellen
(2023-02-15)The primary cilium is gaining increasing importance in research because it is believed that the primary cilium is involved in regulating the differentiation, matrix synthesis potential, and migration of chondrogenic ... -
Evaluation der Interaktionen zwischen extrazellulärer Matrix und ausgewählten tumorassoziierten Proteinen mittels Nahinfrarot-Antikörpern
(2020-10-23)The interplay between tumor cells and their microenvironment is crucial for carcinogenesis and tumor progression. In my thesis, I examine selected tumor-associated proteins that interact with the extracellular matrix ... -
Evaluation der Messgenauigkeit des optix-Systems
(2011-04-27)The optical imaging with the time-domain-based method provides an opportunity to make a statement about investigation objects. The here used optix-system from the Corporation General ... -
In vivo Optical Imaging zum Nachweis der Leberrepopulation nach Konditionierung der Empfängerleber und Hepatozytentransplantation
(2014-05-23)Near infrared fluorescence (NIRF) optical imaging is a technique particularly powerful when studying in vivo processes at the molecular level in preclinical animal models. The purpose of this study was to assess optical ... -
Innovative NIR fluorescent probes for an improved tumor detection in vivo
(2012-05-08)There is a great demand for the development of highly fluorescent and specific probes that enable a sensitive and early detection of malignancies and a separation from healthy tissue in a non-invasive way by in vivo imaging. ... -
Untersuchung des Effekts einer Überexpression von Cathepsin B in Zielzellen zytotoxischer Zellen
(2012-06-12)Cytotoxic T cells lyse malignant tumor cells by releasing perforin and granzymes from preformed cytotoxic granules. Within the cytotoxic response the target cells and the killer cells are exposed to cell death mediators. ... -
Untersuchungen zur Expression der zellzyklusassoziierten Proteine p27Kip1 und Ki-67 und der Matrixmetalloproteinaseinhibitoren TIMP-1, TIMP-2 und TIMP-3 in häufigen humanen Karzinomen
(2011-02-11)Tissue inhibitors of metalloproteinases (TIMP) regulate cell proliferation an play an important role in the extracellular signaling network. p27Kip1 is a member of the cyclin-dependent ... -
Die Wirkung des kompetitiven Gastrin-releasing peptide-(GRP-) -Antagonisten RC 3095 auf das Wachstumsverhalten im Modell experimentell induzierter orthotoper Nierenzellkarzinome – Analyse mittels Volumencomputertomographie (VCT)
(2017-08-21)Despite the use of new drugs, renal tumours are still difficult to treat during the metastatic stage and have an unfavourable prognosis. Consequently, it makes sense to study new therapeutic paths in an animal model. In ... -
Die Wirkung des targeted Chemotherapeutikums AESZ-108 (AN-152) auf GnRH- positive Pankreaskarzinomzelllinien
(2016-10-25)Pancreatic cancer is the fourth commonest cause of cancer-related mortality across the world. Because of the poor response to conventional chemotherapy, small molecules, radiation therapy and surgery, the development ... -
Die Wirkung von GnRH-Analoga auf die Expression von Wachstumsfaktoren und deren Rezeptoren in humanen Mammakarzinomzellen und der Osteoblasten-ähnlichen Zellreihe MG-63 während der Kokultur
(2016-01-13)Breast cancer is the most common cancer of women worldwide. In the advanced stage of the disease, up to 75% of all patients develop bone metastases. Based on the finding that GnRH analogues inhibit the migration and ...