Browsing Human- und Zahnmedizin by Referee "Bickeböller, Heike Prof. Dr."
Now showing items 1-20 of 28
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Assessment and Advancement of Genotype Imputation for genome-wide Association Studies
(2025-05-20)In genome-wide association studies (GWASs), genetic markers are independently tested across the whole genome to find genetic variants associated with a phenotype for a given population. The most commonly used markers for ... -
Assessing the stratification and the prognostic value of SARS-CoV-2 routine data in the context of advanced hospitalization rate 2.0 (HR 2.0)
(2025-01-20)Background: Machine learning is becoming increasingly popular in the field of infection prevention and control. This is particularly evident in the context of surveillance, where screening clinical prediction rules (CPR) ... -
Genetische Polymorphismen im Bereich der Interferon Lambda (IFNL)-Gene und deren prädiktiver Wert für ein Ansprechen auf eine Chemo- oder Radiotherapie bei onkologischen Patienten
(2024-11-29)Chemotherapy and radiotherapy are among the pillars of conventional cancer treatment. The toxic effects of chemotherapeutic agents and the ionizing effects of radiotherapy induce necrosis in neoplastic cells, leading to ... -
Exakte Methoden zur Analyse von Changepoints in binomial-verteilten Sequenzen mit verbesserter Power bei kleinen Fallzahlen
(2024-05-03)Several asymptotic and exact methods exist to detect a change in a sequence of independent binomial random variables. Whenever the sample size or the event rate is small, asymptotic methods may suffer from type I error ... -
Identification of biomarker-defined populations in precision medicine
(2023-03-24)The aim of precision medicine is to identify the treatment that provides the best response for a patient. For this purpose, predictive biomarkers play a crucial role. Due to their ability to define subgroups of patients ... -
Zur Bedeutung von Zytokin- und Zytokinrezeptorgenvariationen bei der Graft-versus-Host Erkrankung nach allogener Blutstammzelltransplantation: Genpolymorphismen von IL6, IL22, TLR4 und TLR9
(2022-12-09)Acute and chronic graft-versus-host reactions (GvHD) remain serious complications of allogeneic blood stem cell transplantation in the treatment of hematologic malignancies. Even in the case of HLA-compatible transplantations, ... -
Retrospektive epidemiologische Untersuchung des Zusammenhangs zwischen der Erkrankung mit sCJK und dem ärztlichen Beruf in Deutschland. Eine Studie mit Patientendaten von 1993 bis 2016.
(2022-11-04)The aim of the present study was to identify a possible risk factor for sporadic Creutzfeldt-Jakob disease (sCJD) through professional activity as a physician. For this purpose a retrospective cohort analysis was performed ... -
Blinded Sample Size Re-estimation for Longitudinal Overdispersed Count Data in Randomized Clinical Trials with an Application in Multiple Sclerosis
(2021-02-22)In many clinical experiments, particularly in randomized clinical trials, the sample size required needs to be assessed and justified. For calculating a clinical trial’s sample size, assumptions have to be made regarding ... -
Bedeutung erblicher Faktoren für die Variabilität der Pharmakokinetik von Arzneimitteln im Vergleich zwischen oraler und intravenöser Dosierung anhand einer Zwillingsstudie
(2020-09-22)The main objective of this study was to investigate hereditary and non-hereditary differences in the activity of the OATP1B1 transporter and the CYP2C9 and CYP3A4 enzymes between oral and intravenous drug dosing. It was ... -
Deskriptive Studie zur zahnärztlichen Betreuung und Versorgung demenzkranker Patienten im Raum Göttingen
(2020-07-30)For dementia patients, dental care generally presents a challenge, in particular due to cognitive impairment, psychic- and behavioral symptoms, as well as an (often subsequently) limited autonomous intraoral care. This ... -
Planung multizentrischer randomisierter klinischer Studien mit kontinuierlichem Endpunkt
(2020-03-31)Multicentre controlled randomized clinical trials are a cornerstone of modern evidence-based medicine. The benefits of collecting data from more than one centre are numerous, including accelerated recruitment and better ... -
Rolle von Single-Nukleotid-Polymorphismen der 11beta-Hydroxysteroid-Dehydrogenase in Bezug auf den Glucocorticoidstoffwechsel im Knochen – Einfluss auf den supprimierten Cortisolspiegel und die Knochendichte bei Osteoporosepatienten
(2019-01-31)The enzyme 11ß-hydroxysteroid dehydrogenase type 1 (11βHSD1) is expressed in osteoblasts and converts inactive cortisone into active cortisol. This enzymatic expression increases with age, suggesting the presence of higher ... -
Adaptive designs for clinical trials in cardiovascular diseases
(2018-12-07)Cardiovascular diseases are diseases of the heart and blood vessels constituting a major cause of death and disability worldwide. Cardiovascular drug development aims to deliver efficacious drugs to address the public ... -
Charakterisierung der weltweiten genetischen Variabilität des Transporters für organische Kationen OCT1
(2017-08-09)The organic cation transporter OCT1 is one of the highest expressed membrane transporters in hepatocytes and mediates the uptake of cationic and weak basic drugs and xenobiotics. The OCT1 gene SLC22A1 is highly polymorphic ... -
Association of Serum Vitamin B12 Levels with Stage of Liver Fibrosis and Treatment Outcome in Patients with Chronic Hepatitis C Virus Genotype 1 Infection
(2017-03-10)Chronic hepatitis C represents a worldwide health problem. In the last years new therapeutic strategies with a very good sustained virological response rate have been developed. These new therapeutic agents are mainly ... -
Einfluss von replizierten Risikogenen auf Kognition und Psychopathologie bei der Schizophrenie
(2016-06-21)Summary: The aim of this thesis consisted in investigating the influence of chosen SNPs of already known and replicated risk genes (TCF4 rs12966547, ZNF804A rs1344706 plus CACNA1C rs1006737, MIR137 rs1625579, MIR137 ... -
Assoziation des PDCD1 rs11568821 GG-Genotyps mit stärkerer Morbidität bei Intensivpatienten mit Krankheitsbild Sepsis: Vergleich der SOFA-Sub-Scores
(2016-06-20)The failing of various therapeutic agents in the treatment of sepsis elucidates the still existing lack of knowledge of this syndrome. Over the last years a major change has taken place as results have shown that, beside ... -
Studie zu erblichen Einflüssen auf die Pharmakokinetik von Midazolam und Koffein
(2015-04-23)The individual effects of drug reaction is subject to large interindividual variations. Based on a better understanding of the causes of these variations and a customization of pharmacotherapies an improvement of the effects ... -
Einfluss des eNOS T-786C-Polymorphismus auf die 5-Jahres-Mortalität und -Morbidität von Patienten nach herzchirurgischen Eingriffen
(2015-04-13)Nitric oxide (NO) is an endothelium-derived relaxing factor (EDRF) which represents one of the most relevant molecules involved in biological systems. NO is produced by three nitric oxide synthase (NOS) isoforms: neuronal ... -
Einfluss des eNOS-G-894-T-Polymorphismus auf die 5-Jahres-Mortalität und-Morbidität kardiochirurgischer Patienten
(2015-03-25)Nitric oxide (NO), an endothelium-derived relaxing factor (EDRF), plays a crucial role in regulating the mammalian cardiovascular system. The endothelial NO Synthase (eNOS) is a key enzyme that synthesizes NO from L-Arginin. ...