Dokumente Human- und Zahnmedizin nach Gutachter "Dressel, Ralf Prof. Dr."
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A combination of repurposed drugs reduces the proliferation and viability of glioblastoma cells
(2021-10-01)Background: Glioblastoma multiforme (GBM) is a malignant primary brain tumour with high rates of recurrence. The tumour is characterized by high molecular diversity. A strategy to simultaneously target different oncogenic ... -
Ablationsbehandlung epikardialer akzessorischer Leitungsbahnen über das Koronarvenensystem bei Kindern und Jugendlichen
(2024-01-24)This retrospective data analysis was used to collect data from 24 patients ≤ 18 years who underwent ablation treatment of accessory pathways within the coronary venous system in Göttingen between October 2002 and December ... -
Das Alter als Verteilungskriterium in der medizinischen humanitären Hilfe
(2023-11-13)Setting priorities in medical humanitarian aid is one of the most pressing issues in this context of particular scarce resources. It is questionable which criteria can be used in case of inescapable allocation decisions ... -
Amputationen der unteren Extremität: Postoperativer Verlauf und Analyse der Versorgungsabläufe
(2022-11-22)Revisions occur 25% to 40% after lower extremity amputation. Some factors increase the risk of revision and are associated with it. The aim of the study was therefore to determine which factors might be associated with ... -
Analysis of Lymphocytes with T regulatory Phenotype in Kidney Allografts of Saint-Petersburg
(2018-01-12)Abstract Background. Renal transplantation is an effective method of renal replacement therapy. The success of transplantation depends on the status of immune system of the recipient and its recognition of donor alloantigens. ... -
Anreicherung und semiautomatisierte Detektion HER2-positiver zirkulierender Tumorzellen im Mammakarzinom
(2023-03-09)In clinical practice HER2 status has so far been determined using tissue samples from biopsies. As sample collection is an invasive, time-consuming procedure for patients, the focus is nowadays on blood-based biomarkers ... -
Assoziation des regulierenden Polymorphismus rs11536889 im TLR4-Gen mit Organ-spezifischer Morbidität und Mortalität bei Patienten mit Sepsis
(2020-09-08)Abstract Background Toll-like receptor 4 (TLR4), a lipopolysaccharide (LPS) receptor complex signal-transducing molecule, plays a crucial role in sensing LPS from gram-negative bacteria. TLR4 signaling pathway activation ... -
Assoziationen psychometrisch erfasster Parameter mit Markern der Immunaktivierung bei Patientinnen und Patienten mit depressiven Syndromen
(2022-10-17)Depressive syndromes and their comorbidities are associated with a substantial psychological and somatic suffering, which significantly affect the general health, quality of life, as well as social and occupational activities ... -
Auswirkung von Enriched Environment auf hippocampalen Nervenzellverlust und Gedächtnisfunktionen im Mausmodell Tg4-42
(2023-02-27)N-truncated Aβ4-42 is one of the Aβ isoforms most frequently present in the brains of patients suffering from Alzheimer's disease. It exhibits an increased propensity for aggregation and increased toxicity, which can lead ... -
Auswirkungen der doppelten Kryoenergieapplikation am wachsenden Schweinemyokard: Läsionsgrößen, Koronaraffektion
(2022-08-12)Double Cryoenergy Application at Growing Myocardium: Lesion Volume and Effects on Coronary Arteries Late after Energy Application -
Auswirkungen einer Variation im TREM-1-Gen auf die Mortalität bei septischen Patienten
(2024-02-12)Sepsis is a life-threatening organ dysfunction caused by a disturbed immune response of the organism to an infectious agent. Sepsis is one of the most common causes of death in intensive care units. Due to its epidemiology ... -
Die Auswirkungen eines FABP5-Knockdowns in chondrogenen Progenitorzellen
(2017-06-08)Osteoarthritis (OA) is a degenerative disease of the joints in the course of which articular cartilage and surrounding tissues are destroyed. Symptoms range from pain to a complete loss of mobility. Previous therapies aim ... -
Bedeutung des löslichen CD14-Rezeptors in Plasma und Urin als immunologischer Parameter nach Nierentransplantation und sein Verhältnis zu den löslichen Rezeptoren IL2R, CD4 und CD8
(2011-05-02)The soluble CD14 (sCD14) is increased in plasma during an immunological activation. For patients following kidney transplantation the avoidance or early detection and treatment of complications ... -
Bestimmung der mitochondrialen Atmungskettenfunktion im Rett-Syndrom mittels hochauflösender Respirometrie
(2023-06-05)Rett syndrome is a disorder frequently caused by pathological changes in the MECP2 gene, an essential transcription factor. It results in various morphological and biochemical alterations in mitochondria, which affect a ... -
Biallelic LZTR1 Mutations Activate RAS- MAPK Signaling and Cause Hypertrophic Cardiomyopathy in iPSC-Derived Cardiomyocytes of a Novel Type of Noonan Syndrome
(2023-02-06)Noonan syndrome is a multisystemic disorder with variable expressivity, characterized by typical craniofacial features, physical and mental retardation with cardiovascular abnormalities. Noonan syndrome is the most common ... -
Cannabinoid-basierte Therapie in einem Modell für die sporadische Alzheimer-Erkrankung
(2022-09-14)The endocannabinoid system (ECS) is involved in several metabolic processes of the human body and has among others a neuroprotective and anti-inflammatory effect on the central nervous system. Tetrahydrocannabinol (THC) ... -
Characterisation of the RNA modifying enzyme ABH1
(2022-04-28)Ribonucleic acid (RNA) modifications have been found in all coding and non-coding RNAs and represent a key mechanism in the homeostatic control of cell metabolism including gene expression and regulation. Therefore, the ... -
Charakterisierung des Expressions- und Proliferationsverhaltens der STRO 1 positiven und -negativen Rosenstockperiostzellen des Europäischen Damhirsches (Cervus dama)
(2016-10-31)Unique in mammals, Cervidae have the ability of annual antler regeneration. Investigations by Rolf et al. (2008) proved for the first time that STRO-1+ mesenchymal stem cells (MSC) are located in the pedicle periosteum and ... -
CT-basierte Radiomic Feature Analyse zur Unterscheidung von malignen und benignen Nierentumoren
(2023-11-10)The renal cell carcinoma is the most common malignant tumor of the kidney, with approximately 15,000 new cases per year in Germany. The incidence of small kidney tumors with often benign characteristics has been increasing ... -
CYR61 und S100A4 als Targets für die Therapie des triple-negativen Mammakarzinoms sowie des Tamoxifen-resistenten Mammakarzinoms
(2022-04-26)Triple-negative breast cancer (TNBC) offers only few therapeutic options due to the lack of ERα and progesterone receptors as well as a non-existing overexpression of HER2. However, even in the case of ERα-positive breast ...