Dokumente Human- und Zahnmedizin nach Gutachter "Gaedcke, Jochen Prof. Dr."
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Das Ausmaß der Fibrose beim duktalen Pankreaskopfkarzinom korreliert mit der Prognose
(2022-11-29)Extension of fibrosis correlates with the prognosis for pancreatic ductal adenocarcinoma (PDA) Müller J, Kitz J, Bernhard M, Azizian A, Grade M, Ströbel P, Ghadimi M, Gaedcke J. Introduction For patients with PDA ... -
Diagnostische und therapeutische Aspekte des Narrow Band Imaging beim Harnblasenkarzinom
(2020-01-31)BACKGROUND: Narrow Band Imaging (NBI) is an easy endoscopic procedure introduced to be beneficial to common white light cystoscopy by using specific bands (hemoglobin absorption maxima) of white light and therefore showing ... -
Diagnostische Varianzen bei Ösophagus- und Magentumoren
(2019-04-02)Oesophageal and gastric carcinomas are within the twenty most common malignancy-related causes of death in Germany. Since early symptoms are rare, the diagnosis is mainly made in late stages. However, to plan therapies ... -
Einfluss verschiedener KRAS-Mutationen auf das Ansprechen von kolorektalen Zellen auf eine 5-Fluorouracil-basierende Radiochemotherapie in Anwesenheit von Rezeptortyrosinkinase-Inhibitoren
(2022-02-14)Aims: Mutations of the proto-oncogene KRAS are supposed to lead to an increased activity of KRAS inducing a constitutive activation of the downstream MAPK signaling pathway. The aim of the work was to investigate the ... -
Einfluss von microRNAs auf die Sensibilität von kolorektalen Tumorzellen gegenüber einer 5-FU-basierten Radiochemotherapie
(2019-08-29)The clinical course of comparable patients (same tumor stage, age, gender and comparable histopathological parameters) suffering from rectal cancer can vary widely. The range of response rates to neoadjuvant chemoradiation ... -
Evaluation der sonographischen Gallenblasenwanddicke als neuer nicht-invasiver Marker für das Vorliegen von Ösophagusvarizen
(2020-10-08)Background: The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening markers ... -
Evaluation von Ramucirumab und FOLFIRI bezüglich Wirksamkeit und Sicherheit in der palliativen Therapie des Magenkarzinoms
(2021-11-26)Advanced gastric cancer is an epithelial neoplasia of the gastrointestinal tract in which metastasis has often occurred at the time of diagnosis. The treatment options in this palliative situation are mostly drug-based and ... -
Klinische Bedeutung des abführenden Schenkels im Vergleich zur Rektoskopie in der Diagnostik vor Ileostomarückverlagerung
(2020-07-23)In the context of visceral resections, the creation of an artificial bowel outlet (stoma) may be necessary. Among other aspects, the protective double loop ileostomy has become established. One lumen, which conveys the ... -
Prädiktive Biomarker für die Entwicklung von high grade acute organ toxicity im Rahmen der Radiochemotherapie bei Patienten mit Kopf-Hals-Tumoren
(2017-11-22)The treatment of head and neck cancers by radiochemotherapy often leads to high grade acute organ toxicity (HGAOT). These side effects impair the patients’ quality of life as well as the local tumor control as they can ... -
Der Tumorsuppressor p53 reguliert HSF1 im Modell des kolorektalen Karzinoms
(2021-07-13)The regulator of the cellular stress response programm HSF1 is regulated by the tumor suppressor p53 by inhibition of the phosphorylation of Ser326. This reduces HSF1 transcriptional activity and halts the stress response ...