Browsing Human- und Zahnmedizin by Referee "Gründker, Carsten Prof. Dr."
Now showing items 1-20 of 33
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Sensibilisierung des triple-negativen Mammakarzinoms gegenüber Tamoxifen durch Hemmung des membranständigen Estrogenrezeptors GPER1
(2025-03-14)Breast cancer that is negative for the estrogen receptor α (ER α), the progesterone receptor and the human epidermal growth factor receptor 2 is referred to as triple-negative breast cancer (TNBC). This tumor subtype is ... -
Einfluss von GnRH-Analoga auf Proliferation und Invasion von GnRH-Rezeptor-positiven Zervixkarzinomzellen
(2024-11-06)Despite a significant decline in the incidence of cervical cancer in Germany due to the intensification of preventive measures, the five-year overall survival rate for cervical cancer remains at 65%. Conversely, cervical ... -
Bedeutung des G-Protein-gekoppelten Estrogen-Rezeptors 1 (GPER1) für die Progression des Vulvakarzinoms
(2024-06-20)The vulvar carcinoma is a gynecological tumor that primarily affects older women. It mostly comprises squamous cell carcinomas. The standard treatment typically involves a triple therapy of radiation, chemotherapy and ... -
Re-Expression von Östrogenrezeptor-α und DERLIN-3 in triple-negativen Mammakarzinomzellen durch den DNA-Methyltransferase-Inhibitor RG108 als Voraussetzung für den therapeutischen Einsatz von Antiöstrogenen und zur Verhinderung des Warburg-Effekts
(2024-05-02)Despite all efforts in preclinical and clinical research, no significant improvement in the prognosis of patients with TNBC has been achieved in recent years. The lack of ERα, which prevents endocrine therapy, and the ... -
Analyse der ARHGAP29-abhängigen Signalisierung der Invasion von Mammakarzinomzellen
(2024-04-08)Despite expanded early detection examinations and improved treatment options, breast cancer remains the most common cause of death from cancer in women worldwide. Fundamental to the development of innovative therapies is ... -
Die Auswirkungen selektiver ERβ-Agonisten auf ERα-positive Brustkrebszellen hängen von den Expressionsniveaus der Östrogenrezeptoren ERα, ERβ und GPER1 und deren Regulation und Interaktion ab
(2023-12-04)Luminal A breast cancers represent the majority of all breast cancers and are more likely to recur and metastasise. In addition, resistance to tamoxifen is a major treatment problem and new therapeutic options are needed. ... -
Hungernder Krebs-Evaluation der Kombinationstherapie mit 2-Deoxy-D-Glukose und Metformin beim Endometriumkarzinom
(2023-09-04)In this thesis, several aspects of the tumor metabolism were examined as an approach for antiproliferative therapies. Thereby, it is shown that therapy with metformin and 2-Deoxy-D-Glucose reaches a significant decrease ... -
Beeinflusst der knockdown des membranständigen Östrogenrezeptors GPER (GPR30) die anti-invasive Wirksamkeit selektiver Östrogenrezeptor beta (ERb)-Agonisten?
(2023-03-13)The aim of the present work was to investigate to what extent suppression of GPER1 affects viability and invasiveness of TNBC cells. In addition, it was of interest to determine whether suppression of GPER1 affects the ... -
Untersuchung zur Expression von Sexualhormonrezeptoren in hPDL-Zellen
(2022-08-09)This dissertation evaluated the gene expression and protein synthesis of sex hormone receptors in human periodontal ligament cells (PDLCs) in relation to donor- and tooth-specific factors with the aim to clarify the debate ... -
Einfluss von GnRH Analoga auf die GLUT1 Expression in Ovarialkarzinomzellen und Rolle des GLUT1 Transporters im Tumorwachstum
(2021-08-26)Ovarian cancer is the leading cause of death in women diagnosed with gynecological cancers. Most of the cases are diagnosed at an advanced stage, which leads to poor outcomes of this disease. Chemotherapy makes the women ... -
Der Einfluss von GnRH-Analoga auf die Zellproliferation und die GPR-30-Expression in triple negativen Mammakarzinomzellen
(2021-08-11)Triple-negative breast cancers lack estrogen receptor α (ERα), progesterone receptor, and do not overexpress human epidermal growth factor receptor 2 (Her-2). Currently there is no specific target therapy. TNBCs frequently ... -
Einfluss von TGF-β auf die EMT-Marker-Expression in Ko-Kulturen oraler Karzinomzellen mit mesenchymalen Stromazellen
(2021-07-16)Objectives: TGF-β1 signaling modulates epithelial mesenchymal transitions (EMT) of head and neck squamous cell carcinoma (HNSCC). Bone marrow mesenchymal stromal cells (BMSC) are able to exert a regulating influence on the ... -
Glucolyse- und Glutaminase-Inhibition zur Therapieoptimierung von Tamoxifen bei ER-positivem Mammakarzinom
(2021-05-26)Breast cancer express hormone receptors to a large extent. This common and important property of hormone sensitivity is used therapeutically as a target by means of tamoxifen as a selective ER modulator, this therapy being ... -
Einfluss von RhoA auf die Invasivität von Mammakarzinomzellen
(2021-05-20)Breast cancer is the most frequent cancer women suffer from. The most common cause of death is metastasis not the tumor itself, in this stage the disease is no longer curable. This underlines the great significance of ... -
Untersuchung zur Rolle des stressinduzierten Proteins Cysteine-rich angiogenic inducer 61 als Biomarker für die Früherkennung von Mammakarzinomen
(2020-11-12)Over 73,000 German citizens are suffering from breast cancer and the trend is rising. Early detection of this disease is therefore of great importance. However, the mere analysis of the resected primary tumor alone, current ... -
Antagonisiert ein ER β-Agonist die Wirkung von ER α im Fett- und Muskelgewebe der ovarektomierten Ratte?
(2018-02-21)In this study we analyzed the effect of ER α 16α-LE2 (3,17-dihydroxy-19-nor-17α-pregna-1, 3,5(10)-triene-21, 16α-lacton) and ER β 8β-VES (8-vinylestra-1, 3,5(10)-triene-3,17β-diol)-Agonist as well as the sex hormone E2 ... -
Die Wirkung der Fraktionen des Extraktes Cimicifuga racemosa BNO 1055 auf die Brustdrüse ovarektomierter Sprague-Dawley-Ratten
(2018-01-04)In the context of demographic change the number of older people is steadily increasing. This repeatedly results in new challenges for medicine and healthcare. Women currently spend more than a third of their lives ... -
Die Wirkung des targeted Chemotherapeutikums AESZ-108 (AN-152) auf GnRH- positive Pankreaskarzinomzelllinien
(2016-10-25)Pancreatic cancer is the fourth commonest cause of cancer-related mortality across the world. Because of the poor response to conventional chemotherapy, small molecules, radiation therapy and surgery, the development ... -
Untersuchungen der lokalen Östrogenbiosynthese in Knorpelgewebe und chrondrogenen Progenitorzellen in späten Stadien der Arthrose
(2016-04-11)This work investigates local estrogen biosynthesis in chrondrogenic progenitor cells and cartilage of late-stage osteoarthritis (OA). Aromatase was found in cartilage taken from patients undergoing total knee replacement. ... -
Expression von RANK / RANKL im Harnblasenkarzinom
(2015-12-03)Background: Bladder cancer causes significant health restrictions and burdens as a common disease, especially among men. The third most common localization for metastases of bladder cancer is the bone which often causes ...