Dokumente Human- und Zahnmedizin nach Gutachter "Hahn, Heidi Prof. Dr."
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1alpha,25-Dihydroxy-VitaminD3 hemmt das Wachstum von Patched-assoziierten Rhabdomyosarkomen und Basaliomen
(2011-11-17)Activation of the Hedgehog (Hh)-signaling pathway due to deficiency in the Hh receptor Patched1 (Ptch) is the pivotal defect leading to formation of rhabdomyosarcomas (RMS) and basal cell carcinoma (BCC). Recent reports ... -
Accumulation of single-stranded DNA in tumour cells as a result of replicative stress
(2018-01-15)Cells are constantly subjected to DNA damaging agents like reactive oxygen species, UV light or, in the case of cancer cells, chemotherapeutic drugs. All these agents can lead to replicative stress, meaning that the most ... -
Analyse der ARHGAP29-abhängigen Signalisierung der Invasion von Mammakarzinomzellen
(2024-04-08)Despite expanded early detection examinations and improved treatment options, breast cancer remains the most common cause of death from cancer in women worldwide. Fundamental to the development of innovative therapies is ... -
Analyzing the Function of PTK7 in Cell Migration
(2012-07-25)Cell migration is very important for embryonic development and maintenance of the adult organism. During development cell migration processes are involved in gastrulation, convergent extension movements and neural crest ... -
Die Auswirkungen eines FABP5-Knockdowns in chondrogenen Progenitorzellen
(2017-06-08)Osteoarthritis (OA) is a degenerative disease of the joints in the course of which articular cartilage and surrounding tissues are destroyed. Symptoms range from pain to a complete loss of mobility. Previous therapies aim ... -
Die Auswirkungen selektiver ERβ-Agonisten auf ERα-positive Brustkrebszellen hängen von den Expressionsniveaus der Östrogenrezeptoren ERα, ERβ und GPER1 und deren Regulation und Interaktion ab
(2023-12-04)Luminal A breast cancers represent the majority of all breast cancers and are more likely to recur and metastasise. In addition, resistance to tamoxifen is a major treatment problem and new therapeutic options are needed. ... -
Bedeutung genetischer Polymorphismen im organischen Kationentransporter OCT1 für die Pharmakokinetik und Nebenwirkungen von Proguanil
(2019-01-22)Currently, only limited data exists regarding organic cation transporter OCT1 in the context of polymorphisms in drug transporters and their impact on pharmacokinetics of drugs in humans. In vitro experiments showed that ... -
Differentielle Methylierung von H3K27 in EZH2 positiven large cell neuroendokrinen Tumoren des Thymus
(2023-02-02)Neuroendocrine thymic tumors represent only 0.4% of all neuroendocrine tumors and are thus very rare. Four subtypes are classified by the WHO. A high-grade subtype is the large cell neuroendocrine carcinoma, which is ... -
Effects of Wnt and different TLR stimulations on microglia-induced invasion of breast cancer cells
(2012-10-31)The role of the benign microenvironment in the primary tumor has recently come into focus. In particular, research has shown that blood-derived macrophages may support tumor progression. By contrast, the role of resident ... -
Einfluss einer ERK1/2-Resistenz auf Zellwachstum und Invasivität von triple-negativen Mammakarzinomzellen
(2023-01-27)Breast cancer is the most common cancer in women. The subtype of triple-negative breast cancer (TNBC) accounts for 10-20%, for which the therapeutic options are limited. The most frequently mutated signaling pathway in ... -
Einfluss von ARHGAP29 auf die Invasion von aggressiven und mesenchymal transformierten Mammakarzinomzellen
(2021-12-06)Despite decades of scientific research and corresponding progress, breast cancer is still the most common carcinoma in women, in Germany and worldwide. Patients’ prognosis deteriorates drastically in metastatic stage. This ... -
Expression von Genen des WNT-Signalwegs in humanen Makrophagen nach MCF-7 Ko-Kultivierung und in murinen Makrophagen nach Mikrovesikel-Stimulation
(2019-09-19)The interaction between malignant cells and stroma cells contributes in a crucial way to their biological activity. In breast cancer there is an association between activation of the canonical WNT-Pathway and aggressive ... -
Identification and functional characterisation of oncogenic pathway signatures in malignant lymphoma
(2012-01-17)B cell aggressive non-Hodgkin lymphomas (aNHL) represent a heterogeneous group of lymphatic malignancies comprising Burkitt Lymphoma (BL) and Diffuse Large B cell lymphoma (DLBCL). aNHL ... -
Innovative NIR fluorescent probes for an improved tumor detection in vivo
(2012-05-08)There is a great demand for the development of highly fluorescent and specific probes that enable a sensitive and early detection of malignancies and a separation from healthy tissue in a non-invasive way by in vivo imaging. ... -
Putative Tumorstammzellen mit SP-Phänotyp in aggressiven B-Zell-Lymphomen
(2015-08-27)The most common aggressive non-Hodgkin's lymphoma (NHL) is the diffuse large B-cell lymphoma (DLBCL) which makes up 30-40% of all NHL. Within many tumor entities, solid as well as hematological, a defined subpopulation ... -
Die Reaktivierung der FMR1-Transkription in Fibroblasten von Patienten mit Fragilem-X-Syndrom durch Methotrexat
(2014-12-16)The characteristical phenotype of patients with fragile X syndrome is caused by a loss of FMRP expression. In this connection a DNA hypermethylation of the promotor region leads to transcriptional silencing of the FMR1 ... -
Die Rolle des Tumorsuppressors p53 in der ungestörten S-Phase
(2020-12-11)The tumor suppressor protein p53 and its functional network are one of the most important means of an organism to protect a cell from the adverse effects of genotoxic stress and to prevent its malignant degeneration. Due ... -
Sensitivierung von Sarkomzellen gegenüber Doxorubizin
(2012-04-11)Doxorubicin is one of the most effective cytostatic agents and is widely used in a variety of tumor entities. Despite being one of the drugs of choice in sarcoma treatment, doxorubicin sometimes does not show any ... -
siRNA-basierte Studien zu der physiologischen Funktion des Transkriptionsfaktors Runx2 in humanen Osteoblasten
(2012-05-29)Physiological osteoblast differentiation is a very complex process. The osteoblast specific transcription factor runx2 with its multiple regulatory mechanisms is essential for proper osteoblast differentiation. Our knowledge ... -
Untersuchungen zur Pathogenese und Therapie der Notch1-abhängigen T-ALL in einem transgenen Rattenmodell.
(2016-10-25)Acute T lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive cancer with high recurrence rate and poor prognosis. Dysregulated Notch signaling accounts for the majority of T-ALL cases in humans. Despite of the important ...