Dokumente Human- und Zahnmedizin nach Gutachter "Hasenfuß, Gerd Prof. Dr."
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Biallelic LZTR1 Mutations Activate RAS- MAPK Signaling and Cause Hypertrophic Cardiomyopathy in iPSC-Derived Cardiomyocytes of a Novel Type of Noonan Syndrome
(2023-02-06)Noonan syndrome is a multisystemic disorder with variable expressivity, characterized by typical craniofacial features, physical and mental retardation with cardiovascular abnormalities. Noonan syndrome is the most common ... -
Einfluss einer diabetischen Stoffwechsellage auf die diastolische Funktion des linken Ventrikels
(2011-06-29)Introduction: Patients with diabetes mellitus suffer from a distinct disease of the heart muscle called diabetic cardiomyopathy, a disease which occurs independently of coronary heart disease ... -
Einfluss einer leitliniengerechten Behandlung des arteriellen Hypertonus auf echokardiographische Parameter der diastolischen Funktion
(2009-12-02)Introduction: Cardiovascular diseases are still one of the most common reasons for morbidity and mortality in Germany. As a result this reflects a substantial expense factor in ... -
Einfluss von Celecoxib auf die Entstehung und den Verlauf einer kardialen Hypertrophie
(2011-03-18)In human hearts, the transition from cardiac hypertrophy to advanced heart failure (HF) is accompanied by a tremendous increase in Akt phosphorylation. In non-myocardial tissue, the ... -
Entwicklung und Erprobung eines in-vitro-Modellsystems zur Untersuchung von lastabhängigen Regulationsvorgängen der myokardialen Genexpression
(2007-01-31)The objective of this study was to develop a control setup for the culture of isotonically contracting muscle strip-preparations, based on an existing isometric long-term culture system. With this setup it would be possible ... -
Etablierung einer Methode zur Herstellung von adulten pluripotenten Stammzellen
(2011-10-17)The irreversible loss of cardiomyocytes after myocardial infarction can lead to chronic heart failure. A stem cell-based cell therapy could be a promising approach for organ regeneration. ... -
Intrakoronare Applikation von autologen adulten Stammzellen aus dem Knochenmark: Erste Erfahrungen mit einem Infarktmodell beim Schwein
(2012-01-30)Myocardial infarction is a common consequence of heart muscle damage and remains a major cause of morbidity and mortality worldwide. Bone marrow-derived cells may contribute to the healing ... -
Modifikation des Hypertrophie-Phänotyps der Myosin-Bindungs-Protein-C defizienten Maus durch Muscle-LIM-Protein
(2011-02-18)Modification of the hypertrophy-phenotype in Myosin-Binding-Protein-C-deficient mice by Muscle-LIM-Protein Approximately 3% of all citizens in the old West German States are affected by ... -
Nukleäre Funktionen des Muscle LIM Proteins in der Herzmuskelhypertrophie
(2011-05-26)In different pathologies of the heart a nuclear location of MLP, which was so far known primarily as a cytosceletal protein, has been observed. In the present work the localisation and ... -
Prävalenz, Risikofaktoren und klinische Ausprägung der systolischen und diastolischen Herzinsuffizienz in einem hausärztlichen Risikokollektiv sowie Wertigkeit echokardiographischer Parameter und natriuretischer Peptide zur Diagnosestellung der diastolischen Herzinsuffizienz
(2011-07-18)Introduction:Because of their rising prevalence both systolic and diastolic heart failure have a great relevance concerning public health and medical economy. Due to the different etiology, ... -
The role of SFRP5 in cardiomyocyte function
(2022-06-17)Heart failure is one of the most common cause of death in Germany. The current treatment options are known to decelerate disease progression, but it cannot be halted or reversed. To date, the underlying molecular mechanisms ... -
Tiefe erweiterte Myektomie und Mobilisation des subvalvulären Mitralklappenapparates bei hypertropher obstruktiver Kardiomyopathie – Operative Ergebnisse und Risiken unter besonderer Berücksichtigung von Patienten mit vorheriger perkutaner transluminaler septaler Myokardablation
(2021-09-30)Hypertrophic cardiomyopathy (HCM) is a global disease of the myocardium with an incidence of 1:200 to 1:500 in the population. Possible clinical manifestations include sudden cardiac death, heart failure, and atrial ... -
Der Totale Rechts/Links - Volumen - Index: ein neuer MRT-Parameter zur Evaluation des Schweregrads der Ebstein - Anomalie - ein prospektiver Vergleich mit verschiedenen klinischen Herzinsuffizienzparametern -
(2015-12-01)Background: The classification of clinical severity of Ebstein’s Anomaly (EA) still remains a challenge. The aim of this study was to focus on the interaction of the pathologically altered right heart with the anatomically ... -
Vergleich des kardialen Remodelings zwischen Vorlastmodell und Nachlastmodell
(2011-08-24)In the group of cardiovascular diseases heart failure is the most common disease. Hemodynamic overload is an important component part of the development of cardiac hypertrophy and heart ... -
Zum Einfluss des Calcineurin and Ras binding protein (Carabin) auf die Wachstumsregulation von Kardiomyozyten
(2012-03-26)In cardiomyocytes Calcineurin-NFAT signaling and ERK/MAPK signaling play essential roles in the pathogenesis of cardiac hypertrophy and heart failure. The Calcineurin and Ras binding protein ... -
Zum Einfluss von DYRK1A auf den aktivierten Calcineurin/NFAT-Signalweg und die Hypertrophie in Kardiomyozyten
(2012-05-24)Aims: The calcineurin and nuclear factor of activated T cells (NFAT) pathway can mediate cardiac pro-hypertrophic signalling. Recently, it has been shown that dual-specificity tyrosine-phosphorylation regulated kinase 1A ...