Browsing Human- und Zahnmedizin by Referee "Heßmann, Elisabeth Prof. Dr."
Now showing items 1-6 of 6
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Das Onkoprotein Mdm4 und seine Wirkung auf die DNA-Replikation
(2024-08-05)The oncoprotein MDM4, together with its family member MDM2, is one of the most important regulators of the tumor suppressor p53. This study demonstrates that loss of MDM4 in p53-deficient cells significantly compromises ... -
Epigenetische Grundlagen der (Kreuz)-Resistenz von Antiandrogenen neuer und neuster Generation
(2024-03-20)Prostate cancer grows androgene-dependent, because of which, antiandrogen therapy is used in advanced tumor stages. Most antiandrogens inhibit the androgen receptor directly, but Abiraterone inhibits androgen synthesis. ... -
Molekular-zytogenetisches Monitoring aus dem peripheren Blut bei Hoch-Risiko-MDS Patienten unter Therapie mit Azacitidin
(2023-11-03)In myelodysplastic syndromes (MDS) pathogenesis, diagnosis, prognosis and also therapy are significantly influenced by chromosomal aberrations. In this retrospective analysis of 76 high-risk MDS patients treated with ... -
Direct optogenetic stimulation of smooth muscle cells to control gastric contractility
(2023-05-02)Rationale: Antral peristalsis is responsible for gastric emptying. Its failure is called gastroparesis and often caused by dysfunction of enteric neurons and interstitial cells of Cajal (ICC). Current treatment options, ... -
Untersuchung der therapeutischen Wirkmechanismen von Kurkumin in diffus intrinsischen Ponsgliomen in Abhängigkeit vom Mutationsstatus im H3F3A-Histongen (H3.3K27M-Mutation)
(2022-10-17)Diffuse intrinsic pontine glioma (DIPG) are pediatric high grade glioma localized in the brainstem and associated with a fatal prognosis. 85% of all DIPG carry a H3K27M mutation, which leads to epigenetic dysregulation ... -
Cancer cell death by mitotic failure upon combined kinase inhibition
(2022-06-02)Cancer cells are prone to replicative stress to a greater extent than healthy cells are. Thus, replicative stress might be a way to target cancer cells in a more specific way than conventional chemotherapeutics do. According ...