Dokumente Human- und Zahnmedizin nach Gutachter "Katschinski, Dörthe Prof. Dr."
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Angiotensin II reguliert das Natriumkanal- Öffnungsverhalten über zwei Mechanismen: IP3-Rezeptoren aktivieren die CaMKII und ROS die PKA
(2017-09-19)Background: In heart failure (HF) disturbed CaMKII-dependent sodium current (INa) and sodium channel gating leads to arrhythmias and contractile dysfunction. Enhanced Angiotensin II (Ang II) signaling has been implicated ... -
Die Bedeutung der Kalzium/Calmodulin-abhängigen Proteinkinase II für den gestörten Kalziumstoffwechsel der isolierten Rattenherzmuskelzelle unter Doxorubicinbehandlung
(2013-07-08)Doxorubicin (DOX), a member of the anthracycline family, is one of the oldest and most commonly used chemotherapeutic agents. Despite its therapeutic benefits, its cardiotoxic potential, resulting in severe cardiac damage, ... -
Die Bedeutung der Proteinkinase A und der Ca2+/Calmodulin abhängigen Proteinkinase II für das Sarkoplasmatische Retikulum Kalziumleck in der humanen Hypertrophie und Herzinsuffizienz
(2022-09-22)Sarcoplasmic reticulum (SR) Ca2+ leak through ryanodine receptor type 2 (RyR2) hyperphosphorylation is a key pathomechanism in human heart failure (HF). The resulting increased spontaneous diastolic calcium release promotes ... -
Characterisation of human ribosome assembly factors
(2023-11-09)Ribosomes are highly conserved ribonucleoprotein complexes for translating the genetic code encoded in mRNAs into functional proteins. In consist of a small and large subunit containing ribosomal RNAs as well as ribosomal ... -
Characterization of the cytosolic and mitochondrial glutathione redox potential using cardiomyocyte specific transgenic Grx1-roGFP2 sensor mice
(2023-01-20)In the field of redox biology, the mainly negative perception of reactive oxygen species has given way to the global concept of an intracellular redox balance. Free radicals like H2O2 not only lead to harmful effects within ... -
Chemoresistenz als Folge einer Inhibition der zellulären Sauerstoffsensoren (Prolyl-4-Hydroxylase-Domäne)
(2011-10-18)The hypoxia-inducible factor (HIF) is the master regulator for oxygen-dependent gene expression. The HIF signal transduction pathway can be manipulated by inhibiting the activity of the ... -
Funktionelle Charakterisierung der Kalzium/Calmodulin-abhängigen Proteinkinase-II-δ (CaMKIIδ)-Knockout-Maus
(2013-12-03)CaMKII, the Ca2+/Calmodulin-dependent protein kinase-II, is a multifunctional serine/threonine protein kinase that is a central regulator of cardiomyocyte excitation-contraction-coupling. Several isoforms exist. In the ... -
Hemmung der p38-MAP-Kinase und der Produktion von Superoxidradikalen erhöht die dehnungs-induzierte myokardiale Kraftentwicklung
(2012-01-04)Acute right ventricular (RV) stretch and dilatation predicts RV contractile failure in pulmonary embolism. Myocardial stretch rapidly activates p38 MAP kinase, which decreases calcium ... -
Hypoxia stimulates retrograde membrane trafficking to the trans-Golgi network via recruitment of T-plastin
(2018-10-24)Hypoxia is essential for many physiological functions but also plays a pivotal role in the pathogenesis of a variety of epidemiologically highly relevant diseases. Adequate adaptation mechanisms to oxygen deprivation are ... -
Inhibtion der Ca<sup>2+</sup>/Calmodulin-abhängigen Proteinkinase (CaMKII) verbessert die Kontratilität von terminal insuffizientem Myokard des Menschen
(2011-12-12)Heart failure is known to be associated with increased Ca2+/calmodulin-dependent protein kinase (CaMKII) expression and activity. But the functional effects of CaMKII and detailed expression ... -
Investigation of genetic and translational effects of tumor suppressor proteins in two hereditary forms of renal cell carcinoma
(2021-05-07)Some familial cancer syndromes are known to cause renal cell carcinoma (RCC) in afflicted subjects. I studied the role of tumor suppressor genes in two syndromes: Birt-Hogg-Dubé (BHD) and von Hippel-Lindau (VHL). BHD is ... -
Membranprotein-Komposition von Kardiofibroblasten in Normoxie und Hypoxie
(2019-10-08)Hypoxia is a key element in the pathophysiology of ischemic, inflammatory and malignant neoplastic diseases. It also plays an essential role in the intrauterine environment during embryonic development as well as in stem-cell ... -
Molecular Basis of Mitochondrial Diseases Exemplified by Mutation of the Translation Factor Cox14
(2023-11-07)Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. More and more evidence shows that mitochondrial ... -
Nukleäre Funktionen des Muscle LIM Proteins in der Herzmuskelhypertrophie
(2011-05-26)In different pathologies of the heart a nuclear location of MLP, which was so far known primarily as a cytosceletal protein, has been observed. In the present work the localisation and ... -
Die Rolle des späten Natriumstroms (late INa) bei Druck-induzierter Hypertrophie und bei Herzinsuffizienz
(2015-03-11)Heart failure, is associated with high mortality as a result of contractile dysfunction (pump failure) or sudden death caused by ventricular arrhythmias. There usually is an imbalance of cellular calcium (Ca2+) and sodium ... -
Die Rolle von ERK1/2 im Prozess des kardialen Remodelings während chronischer Volumenbelastung
(2023-11-23)Chronic heart failure is a disease of great socio-economic importance due to its high prevalence, reduced quality of life, poor prognosis and high healthcare costs. The causes of heart failure include hemodynamic stressors, ... -
Strukturelle und funktionale Veränderungen der atrialen Kalzium-Freisetzungseinheit im Herzinsuffizienzmodell durch Junctophilin-2-Knockdown
(2021-03-05)In this work, the effects of a cardiac-specific tamoxifen-mediated junctophilin-2 (JPH2) knockdown in mice on structure and function of the atria and atrial cardiomyocytes (AM) were investigated. Atrial JPH2 protein ... -
SUMOylierung in Nervenzellen und deren Regulation durch Sauerstoff und Glukose
(2023-04-27)Small ubiquitin-like modifiers (SUMO) are post-translational modifications (PTM) which, similar to Ubiquitin, are conjugated to specific target proteins. The conjugation is based on an energy-dependent enzymatic cascade, ... -
TGFbeta und Fibrose der Haut
(2021-06-29)Systemic sclerosis (SSc) is a fibrotic disease characterized by TGFβ-mediated differentiation of dermal fibroblasts to contractile myofibroblasts leading to accumulation of extracellular matrix proteins. Multiple studies ... -
The role of tubulin acetylation in cardiac fibroblasts
(2018-09-25)Cardiac fibroblasts and their activation upon cardiac damage play a key role in pathological cardiac remodelling and the development of cardiac fibrosis. This thesis investigates the role of α-tubulin acetylation in cardiac ...