Browsing Human- und Zahnmedizin by Referee "Kneib, Thomas Prof. Dr."
Now showing items 1-6 of 6
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Genome-wide association studies and follow-up kernel approaches in the longitudinal PsyCourse Study
(2023-02-23)A genetic association study is a popular method to analyse the connection of genomic factors with disorders or disease-related phenotypes. There are various study types including genome-wide association studies (GWASs) and ... -
Methods for Blinded Sample Size Recalculation in Adaptive Enrichment Designs
(2022-12-21)In precision medicine the potential heterogeneity of patient populations becomes more accessible through technical and medical innovations. A population might be heterogeneous and different strata may in turn respond ... -
Association Analysis Using Set-Based Approaches in the Post-GWAS Era
(2021-08-10)Genotyping arrays have greatly facilitated genetic epidemiological studies into genetic risk factors for numerous complex diseases such as psychiatric disorders. The use of genome-wide association analysis (GWAS) is ... -
Bayesian methods for borrowing information in clinical drug development
(2020-12-11)Clinical drug development is the process of investigating potential pharmaceutical therapies in clinical trials. The clinical investigation of drugs consists of four phases. The aim is bringing a candidate drug from early ... -
Kernel-Based Pathway Approaches for Testing and Selection
(2017-10-12)With the number of single nucleotide polymorphisms (SNPs) available in genetic data currently constantly increasing, the evaluation of SNP sets has become a successful approach toward elucidating the genetic influence on ... -
Kernel Methods for Genes and Networks to Study Genome-Wide Associations of Lung Cancer and Rheumatoid Arthritis
(2014-02-28)The search for genetic causes of common complex diseases has been revolutionized by the ability to genotype exceptionally large numbers of single nucleotide polymorphisms (SNPs) in hundreds of individuals at an affordable ...